Skip to main content

Pancreatic Adenocarcinoma Surveillance Counterpoint: Canada

  • Chapter
  • First Online:
Patient Surveillance After Cancer Treatment

Part of the book series: Current Clinical Oncology ((CCO))

  • 154 Accesses

Abstract

Ductal adenocarcinoma accounts for over 90 % of pancreatic malignancies. Other less common pancreatic tumors include neuroendocrine cancers, acinar cell carcinoma, pancreatoblastoma, squamous cell carcinoma, and occasional benign conditions. Rarely, the pancreas can be the site of metastases from other solid tumor malignancies (e.g., colon, breast, renal cancer) [1]. Pancreatic adenocarcinoma has a mortality rate virtually identical to that of its incidence with conventional cancer treatments having little impact on long-term survival. In Canada, about 3,800 new cases and about 3,700 deaths from pancreatic cancer occur annually. It is the fourth leading cause of cancer-related death in both males and females (4.6 % and 5.6 % of cancer-related deaths, respectively) [2].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. De Vita Jr VT, Lawrence T, Rosenberg SA. Cancer. Principles and practice of oncology. 8th ed. Vol. 1. Philadelphia, PA; 2008. p. 1118-1120.

    Google Scholar 

  2. Canadian Cancer Society/National Cancer Institute of Canada: Canadian cancer statistics 2007. Toronto, Canada. 2008; ISSN 0835-2976.

    Google Scholar 

  3. Kern S, Hruban R, Hollingsworth MA, Brand R, Adrian TE, Jaffae E, et al. A white paper: the product of a pancreas cancer think tank. Cancer Res. 2001;61:4923–32.

    PubMed  CAS  Google Scholar 

  4. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics 2008. CA Cancer J Clin. 2008;58:71–96.

    Article  PubMed  Google Scholar 

  5. Varadhachary GR, Tamm EP, Abbruzzese JL, et al. Borderline resectable pancreatic cancer: definitions, management and role of preoperative therapy. Ann Surg Oncol. 2006;13:1035–46.

    Article  PubMed  Google Scholar 

  6. Li D, Xie K, Wolff R, Abbruzzese JL. Pancreatic cancer. Lancet. 2004;363:1049–57.

    Article  PubMed  CAS  Google Scholar 

  7. Berger HG, Rau B, Gansauge F, et al. Treatment of pancreatic cancer: challenge of the facts. World J Surg. 2003;27:1075–84.

    Article  Google Scholar 

  8. Crist DW, Sitzmann JV, Cameron JL. Improved hospital morbidity, mortality and survival after the Whipple procedure. Ann Surg. 1987;206:358–65.

    Article  PubMed  CAS  Google Scholar 

  9. Sohn TA, Yeo CJ, Cameron JL, et al. Resected adenocarcinoma of the pancreas-616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg. 2001;5:681.

    Article  Google Scholar 

  10. Birkmeyer JD, Siewers AE, Finlayson EV, et al. Hospital volume and surgical mortality in the United States. N Engl J Med. 2002;346:1128–37.

    Article  PubMed  Google Scholar 

  11. Verslype C, Van Cutsem E, Dicato M, et al. The management of pancreatic cancer. Current expert and recommendations derived from the 8th World Congress on Gastrointestinal Cancer, Barcelona, 2006. Ann Oncol. 2007;18 Suppl 7:vii1–10.

    Article  PubMed  Google Scholar 

  12. Pedrazzoli S, DiCarlo V, Dionigi R, et al. Standard versus extended lymphadenectomy associated with pancreaticoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study. Lymphadenectomy Study Group. Ann Surg. 1998;228:508–17.

    Article  PubMed  CAS  Google Scholar 

  13. Alexakis N, Halloran C, Raraty M, Ghaneh P, Sutton R, Neoptolemeos JP. Current standards of surgery for pancreatic cancer. Br J Surg. 2004;91:1410–27.

    Article  PubMed  CAS  Google Scholar 

  14. Yeo CJ, Cameron JL, Lillemoe KD, et al. Pancreaticoduodenectomy for cancer of the pancreas. 201 patients. Ann Surg. 1995;22:721–33.

    Article  Google Scholar 

  15. Kaiser MH, Ellenberg SS. Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg. 1985;120:899–903.

    Article  Google Scholar 

  16. Klinkerbijl JH, Jeekel J, Sahmoud T, et al. Adjuvant radiotherapy and 5-fluorouracil after resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC gastrointestinal tract cancer group. Ann Surg. 1999;230:776–82. discussion 782–784.

    Article  Google Scholar 

  17. Neoptolemos JP, Stocken DD, Friess H, et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med. 2004;350:1200–10.

    Article  PubMed  CAS  Google Scholar 

  18. Heinemann V, Boeck S. Perioperative management of pancreatic cancer. Ann Oncol. 2008;19 Suppl 7:vii273–8.

    Article  PubMed  Google Scholar 

  19. Crane CH, Ben-Losef E, Small Jr W. Chemotherapy for pancreatic cancer. N Engl J Med. 2004;350:2713–5. author reply 2713–1715.

    Article  PubMed  CAS  Google Scholar 

  20. Oettle H, Post S, Neuhaus P, et al. Adjuvant chemotherapy with gemcitabine vs. observation in patients undergoing curative-intent resection of pancreatic cancer. JAMA. 2007;297:267–77.

    Article  PubMed  CAS  Google Scholar 

  21. Neuhaus P, Riess H, Post S, et al. CONKO-001: final results of the randomized, prospective, multicentre phase III of adjuvant chemotherapy and gemcitabine versus observation in patients with resected pancreatic cancer. ASCO Annual Meeting Proceedings. 2008;26(18S):LBA4504.

    Google Scholar 

  22. Rhodes JM. Usefulness of novel tumor markers. Ann Oncol. 1999;10 Suppl 4:S118–21.

    Article  Google Scholar 

  23. Hermann R, Jelic S. Pancreatic cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 2008;19 Suppl 2:ii25–6.

    Article  Google Scholar 

  24. NCCN clinical guidelines in oncology. Pancreatic Adenocarcinoma. Version 1.207. www.nccn.org.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Malcolm J. Moore M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Humana Press

About this chapter

Cite this chapter

Moore, M.J., Stathis, A. (2013). Pancreatic Adenocarcinoma Surveillance Counterpoint: Canada. In: Johnson, F., et al. Patient Surveillance After Cancer Treatment. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-969-7_26

Download citation

  • DOI: https://doi.org/10.1007/978-1-60327-969-7_26

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60327-968-0

  • Online ISBN: 978-1-60327-969-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics