Pancreatic Adenocarcinoma Surveillance Counterpoint: Europe

  • Richard A. Smith
  • Jane V. Butler
  • John P. NeoptolemosEmail author
Part of the Current Clinical Oncology book series (CCO)


Exocrine pancreatic cancer accounts for almost a quarter of a million deaths worldwide each year with approximately one third arising in Europe [1, 2]. Despite being only the thirteenth most common malignancy worldwide, it is the eighth most frequent cause of cancer mortality [2]. The singularly aggressive nature of this disease is further underlined by the fact that mortality rates continue to approximate the incidence [3]. There has been a marginal decline in both age-standardised incidence and mortality rates over the past 20 years [3, 4].


United Kingdom Exocrine Signet ring cell carcinoma Penetrance Pancreatoduodenectomy 



Ductal adenocarcinoma

Carcinoma arising from epithelial cells within the pancreatic duct

Mucinous non-cyctic neoplasm

Cysts lined by mucin-producing cells may be unilocular or multilocular

Signet ring cell carcinoma

Cancer derived from epithelial cells with a characteristic histological appearance resembling a signet ring

Autosomal dominant

Mode of inheritance whereby inheritance of one copy of an abnormal gene from a non-XY chromosome will result in expression of the phenotype

Penetrance (genetics)

The proportion of those carrying the gene mutation who express the phenotype, e.g. penetrance is said to be incomplete if a certain proportion of those with the mutation do not exhibit any clinical features of the trait; penetrance is complete of all those individuals carrying the mutation express the trait


Surgical removal of the head of the pancreas and most of the duodenum, usually pylorus preserving

Kausch Whipple

Eponymous name associated with pancreatoduodenectomy; Walther Kausch performed the first surgical removal of the duodenum and a portion of the pancreas in a two-stage procedure in 1912: Allen Whipple performed the procedure at a later date before adopting a one-stage technique


A surgical join between two hollow structures; this join may leak (anastomotic leak) and may cause narrowing (anastomotic stricture) in the event of a fibrous scar tissue formation


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Copyright information

© Humana Press 2013

Authors and Affiliations

  • Richard A. Smith
    • 1
  • Jane V. Butler
    • 1
  • John P. Neoptolemos
    • 1
    Email author
  1. 1.Division of Surgery and OncologyThe Owen and Ellen Evans Chair of Cancer Studies, School of Cancer Studies, Royal Liverpool University Hospital, University of LiverpoolLiverpoolUK

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