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Into the Future: Autonomic Neuropathy, MicroRNAs, and Gene Therapy

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Sjögren’s Syndrome

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Abstract

Understanding the pathogenesis of Sjögren’s syndrome (SS) has proved to be challenging. Both immune-mediated and non-immune-mediated mechanisms have been implicated, which adds to the complexity of the problem. However, recent developments in science and technology have given researchers new opportunities for exploring this fascinating disease. In this chapter we provide a synopsis of the progress in our understanding of the role of the autonomic nervous system in SS pathogenesis, the role of microRNAs as novel tools in advancing research in this field, and gene therapy as potential therapeutic avenue.

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Author information

Authors and Affiliations

  1. Sjögren’s Syndrome Clinic, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA

    Ilias Alevizos & Nikolay P. Nikolov

  2. Department of Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD, USA

    John A. Chiorini

Authors
  1. Ilias Alevizos
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  2. John A. Chiorini
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  3. Nikolay P. Nikolov
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Corresponding author

Correspondence to Nikolay P. Nikolov .

Editor information

Editors and Affiliations

  1. Research Foundation, Rheumatology Clinic, Scripps Memorial Hospital &, Caminito Sinnecock 6565, La Jolla, 92037, California, USA

    Robert I. Fox

  2. Research Foundation, Rheumatology Clinic, Scripps Memorial Hospital &, Caminito Sinnecock 6565, La Jolla, 92037, California, USA

    Carla M. Fox

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Alevizos, I., Chiorini, J.A., Nikolov, N.P. (2011). Into the Future: Autonomic Neuropathy, MicroRNAs, and Gene Therapy. In: Fox, R., Fox, C. (eds) Sjögren’s Syndrome. Springer, New York, NY. https://doi.org/10.1007/978-1-60327-957-4_34

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  • DOI: https://doi.org/10.1007/978-1-60327-957-4_34

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-60327-956-7

  • Online ISBN: 978-1-60327-957-4

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