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Diabetes and Depression

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Diabetes and the Brain

Part of the book series: Contemporary Diabetes ((CDI))

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Abstract

Diabetes mellitus affects about 20% of adults older than 65 years of age and its prevalence among Americans is reaching epidemic proportions. In cross-sectional studies, diabetes mellitus has been associated with various complications and comorbid conditions, especially psychiatric disorders. The relationship between diabetes and depression is particularly complex. Evidence demonstrates high co-occurrence of these disorders, with associated poorer medical outcomes. Studies have also shown an increased risk for Alzheimer’s disease and more rapid cognitive decline for diabetic patients. The neuroanatomic changes that occur in depression, as well as the neurochemical, neuroendocrine, and resultant inflammatory effects that occur in patients with co-occurring depression and diabetes, are reviewed. The range of treatments for depression including pharmacologic and non-pharmacologic is discussed, with particular consideration of impact of these treatments on patients with diabetes and/or cognitive impairment.

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Authors and Affiliations

  1. Psychiatry Service, Miami VA Healthcare System, Miller School of Medicine at the University of Miami, Miami, FL, USA

    Maria D. Llorente MD (Chief)

  2. Health Science Specialist, Miami VA Healthcare System, Assistant Professor of Psychiatry, Miller School of Medicine, University of Miami, Miami, FL, USA

    Julie E. Malphurs PhD

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  1. Maria D. Llorente MD
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Correspondence to Maria D. Llorente MD .

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Editors and Affiliations

  1. Dept. Neurology, University Medical Center Utrecht, Utrecht, 3508 GA, Netherlands

    Geert Jan Biessels

  2. Medical Center, Columbia University, West 168th St. 622, New York, 10032, U.S.A.

    Jose A. Luchsinger

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Llorente, M.D., Malphurs, J.E. (2009). Diabetes and Depression. In: Biessels, G., Luchsinger, J. (eds) Diabetes and the Brain. Contemporary Diabetes. Humana Press. https://doi.org/10.1007/978-1-60327-850-8_14

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