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Insulin Resistance and Non-alcoholic Fatty Liver Disease Induced by Conjugated Linoleic Acid in Humans

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Modern Dietary Fat Intakes in Disease Promotion

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Key Points

• Mixed isomers of conjugated linoleic acid and purified t10, c12-CLA decreased body weight and body fat mass in animal models but not humans.

• Conjugated linoleic acid supplementation in humans have been shown to cause insulin resistance and fatty liver. Because of lack of any significant health benefit from CLA consumption and its associated risks on insulin resistance and fatty liver, this natural or synthetic group of fatty acids cannot be recommended as a supplement that can be used to improve human health.

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Authors and Affiliations

  1. Department of Nutrition, Western Human Nutrition Research Center, ARS, USDA, University of California, Davis, CA, 95616, USA

    Madhuri Vemuri

  2. Western Human Nutrition Research Center, ARS, USDA, Department of Nutrition, University of California, Davis, CA, 95616, USA

    Darshan S. Kelley

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  1. Madhuri Vemuri
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Correspondence to Darshan S. Kelley .

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  1. Managing Director, DMF Ltd Company, Luxembourg Str 46, Marche/Famenne, 6900, Belgium

    Fabien De Meester

  2. Mel & Enid Zuckerman College of, Public Health, University of Arizona, Tucson, 85724-5163, Arizona, USA

    Sherma Zibadi

  3. Arizona Health Science Center, Mel and Enid Zuckerman College of Public, University of Arizona, 1501 N. Campbell Ave. Room 4335, Tucson, 85724-5155, Arizona, USA

    Ronald Ross Watson

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Vemuri, M., Kelley, D.S. (2010). Insulin Resistance and Non-alcoholic Fatty Liver Disease Induced by Conjugated Linoleic Acid in Humans. In: De Meester, F., Zibadi, S., Watson, R. (eds) Modern Dietary Fat Intakes in Disease Promotion. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-571-2_9

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