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Etiology and Risk Factors of Erectile Dysfunction

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Contemporary Treatment of Erectile Dysfunction

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

A wide variety of risk factors contribute to erectile dysfunction (ED). Many of these risk factors are treatable yet go unrecognized. Further, many of the treatments of these risk factors have also been implicated in causing the disease. Thus, the treatment of ED may be a complicated issue for the general practitioner. The majority of this chapter focuses on the correlation between cardiovascular disease and erectile dysfunction. A major benefit of screening for ED is that it may lead to early diagnosis of subclinical cardiovascular disease, alerting the clinician to potential treatment intervention in these patients.

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References

  1. Feldman, H. A., et al. (1994). Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. Journal d’Urologie, 151(1), 54–61.

    CAS  Google Scholar 

  2. Bacon, C. G., et al. (2006). A prospective study of risk factors for erectile dysfunction. Journal d’Urologie, 176(1), 217–221.

    Google Scholar 

  3. Kupelian, V., et al. (2008). Socioeconomic status, not race/ethnicity, contributes to variation in the prevalence of erectile dysfunction: Results from the Boston Area Community Health (BACH) Survey. The Journal of Sexual Medicine, 5(6), 1325–1333.

    Article  PubMed  Google Scholar 

  4. O’Kane, P. D., & Jackson, G. (2001). Erectile dysfunction: Is there silent obstructive coronary artery disease? International Journal of Clinical Practice, 55(3), 219–220.

    PubMed  Google Scholar 

  5. McKinlay, J. B. (2000). The worldwide prevalence and epidemiology of erectile dysfunction. International Journal of Impotence Research, 12(Suppl 4), S6–S11.

    Article  PubMed  Google Scholar 

  6. Solomon, H., DeBusk, R. F., & Jackson, G. (2005). Erectile dysfunction: The need to be evaluated, the right to be treated. American Heart Journal, 150(4), 620–626.

    Article  PubMed  Google Scholar 

  7. Schouten, B. W., et al. (2008). Erectile dysfunction prospectively associated with cardiovascular disease in the Dutch general population: Results from the Krimpen Study. International Journal of Impotence Research, 20(1), 92–99.

    Article  CAS  PubMed  Google Scholar 

  8. Sullivan, M. E., et al. (1999). Nitric oxide and penile erection: Is erectile dysfunction another manifestation of vascular disease? Cardiovascular Research, 43(3), 658–665.

    Article  CAS  PubMed  Google Scholar 

  9. Solomon, H., Man, J. W., & Jackson, G. (2003). Erectile dysfunction and the cardiovascular patient: Endothelial dysfunction is the common denominator. Heart, 89(3), 251–253.

    Article  CAS  PubMed  Google Scholar 

  10. Junemann, K. P., et al. (1991). The effect of impaired lipid metabolism on the smooth muscle cells of rabbits. Urological Research, 19(5), 271–275.

    Article  CAS  PubMed  Google Scholar 

  11. Billups, K., & Friedrich, S. (2000). Assessment of fasting lipid panels and Doppler ultrasound testing in men presenting with erectile dysfunction and no other problems. The Journal of Urology, 163(4), 147.

    Google Scholar 

  12. Saltzman, E. A., Guay, A. T., & Jacobson, J. (2004). Improvement in erectile function in men with organic erectile dysfunction by correction of elevated cholesterol levels: A clinical observation. Journal d’Urologie, 172(1), 255–258.

    Google Scholar 

  13. Rizvi, K., Hampson, J. P., & Harvey, J. N. (2002). Do lipid-lowering drugs cause erectile dysfunction? A systematic review. Family Practice, 19(1), 95–98.

    Article  PubMed  Google Scholar 

  14. Kloner, R. A., et al. (2003). Erectile dysfunction in the cardiac patient: How common and should we treat? Journal d’Urologie, 170(2 Pt 2), S46–S50. Discussion S50.

    Article  Google Scholar 

  15. Burchardt, M., et al. (2000). Hypertension is associated with severe erectile dysfunction. Journal d’Urologie, 164(4), 1188–1191.

    CAS  Google Scholar 

  16. Behr-Roussel, D., et al. (2003). Erectile dysfunction in spontaneously hypertensive rats: Pathophysiological mechanisms. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 284(3), R682–R688.

    CAS  PubMed  Google Scholar 

  17. Jensen, J., et al. (1999). The prevalence and etiology of impotence in 101 male hypertensive outpatients. American Journal of Hypertension, 12(3), 271–275.

    Article  CAS  PubMed  Google Scholar 

  18. Pritzker, M. R. (2000). The penile stress test: A window to the hearts of man? Circulation, 100, P3751.

    Google Scholar 

  19. Thompson, I. M., et al. (2005). Erectile dysfunction and subsequent cardiovascular disease. Journal of the American Medical Association, 294(23), 2996–3002.

    Article  CAS  PubMed  Google Scholar 

  20. Montorsi, P., et al. (2006). Association between erectile dysfunction and coronary artery disease. Role of coronary clinical presentation and extent of coronary vessels involvement: The COBRA trial. European Heart Journal, 27(22), 2632–2639.

    Article  PubMed  Google Scholar 

  21. Esposito, K., et al. (2004). Effect of lifestyle changes on erectile dysfunction in obese men: A randomized controlled trial. Journal of the American Medical Association, 291(24), 2978–2984.

    Article  CAS  PubMed  Google Scholar 

  22. Esposito, K., et al. (2008). Obesity and sexual dysfunction, male and female. International Journal of Impotence Research, 20(4), 358–365.

    Article  CAS  PubMed  Google Scholar 

  23. Giugliano, D., Giugliano, F., & Esposito, K. (2006). Sexual dysfunction and the Mediterranean diet. Public Health Nutrition, 9(8A), 1118–1120.

    Article  PubMed  Google Scholar 

  24. Esposito, K., et al. (2006). Mediterranean diet improves erectile function in subjects with the metabolic syndrome. International Journal of Impotence Research, 18(4), 405–410.

    Article  CAS  PubMed  Google Scholar 

  25. Shabsigh, R., et al. (2005). Health issues of men: Prevalence and correlates of erectile dysfunction. Journal d’Urologie, 174(2), 662–667.

    CAS  Google Scholar 

  26. Greenstein, A., et al. (1997). Does severity of ischemic coronary disease correlate with erectile function? International Journal of Impotence Research, 9(3), 123–126.

    Article  CAS  PubMed  Google Scholar 

  27. Kostis, J. B., et al. (2005). Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference). The American Journal of Cardiology, 96(12B), 85M–93M.

    Article  PubMed  Google Scholar 

  28. Schiavi, R. C., et al. (1993). Diabetes mellitus and male sexual function: A controlled study. Diabetologia, 36(8), 745–751.

    Article  CAS  PubMed  Google Scholar 

  29. Klein, R., et al. (1996). Prevalence of self-reported erectile dysfunction in people with long-term IDDM. Diabetes Care, 19(2), 135–141.

    Article  CAS  PubMed  Google Scholar 

  30. Salama, N. (2004). Nocturnal electrobioimpedance volumetric assessment in diabetic men with erectile dysfunction before and after tadalafil intake. International Journal of Impotence Research, 16(5), 441–447.

    Article  CAS  PubMed  Google Scholar 

  31. Wang, C. J., et al. (1993). Penile blood flow study in diabetic impotence. Urologia Internationalis, 50(4), 209–212.

    Article  CAS  PubMed  Google Scholar 

  32. Saenz de Tejada, I., et al. (1989). Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. The New England Journal of Medicine, 320(16), 1025–1030.

    Article  CAS  PubMed  Google Scholar 

  33. Costa, C., et al. (2009). Increased endothelial apoptotic cell density in human diabetic erectile tissue – Comparison with clinical data. The Journal of Sexual Medicine, 6(3), 826–835.

    Article  PubMed  Google Scholar 

  34. Esposito, K., et al. (2008). Phenotypic assessment of endothelial microparticles in diabetic and nondiabetic men with erectile dysfunction. The Journal of Sexual Medicine, 5(6), 1436–1442.

    Article  PubMed  Google Scholar 

  35. Morano, S., et al. (2007). Circulating monocyte oxidative activity is increased in patients with type 2 diabetes and erectile dysfunction. Journal d’Urologie, 177(2), 655–659.

    Google Scholar 

  36. Angulo, J., et al. (2006). Enhanced thromboxane receptor-mediated responses and impaired endothelium-dependent relaxation in human corpus cavernosum from diabetic impotent men: Role of protein kinase C activity. The Journal of Pharmacology and Experimental Therapeutics, 319(2), 783–789.

    Article  CAS  PubMed  Google Scholar 

  37. Seftel, A. D., et al. (1997). Advanced glycation end products in human penis: Elevation in diabetic tissue, site of deposition, and possible effect through iNOS or eNOS. Urology, 50(6), 1016–1026.

    Article  CAS  PubMed  Google Scholar 

  38. Zheng, H., et al. (2006). Predictors for erectile dysfunction among diabetics. Diabetes Research and Clinical Practice, 71(3), 313–319.

    Article  PubMed  Google Scholar 

  39. Sun, P., et al. (2006). Erectile dysfunction – An observable marker of diabetes mellitus? A large national epidemiological study. Journal d’Urologie, 176(3), 1081–1085. Discussion 1085.

    Google Scholar 

  40. Seftel, A. D., Sun, P., & Swindle, R. (2004). The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction. Journal d’Urologie, 171(6 Pt 1), 2341–2345.

    Google Scholar 

  41. Fonseca, V., et al. (2004). Impact of diabetes mellitus on the severity of erectile dysfunction and response to treatment: Analysis of data from tadalafil clinical trials. Diabetologia, 47(11), 1914–1923.

    Article  CAS  PubMed  Google Scholar 

  42. Ford, E. S., Giles, W. H., & Dietz, W. H. (2002). Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey. Journal of the American Medical Association, 287(3), 356–359.

    Article  PubMed  Google Scholar 

  43. Esposito, K., et al. (2005). High proportions of erectile dysfunction in men with the metabolic syndrome. Diabetes Care, 28(5), 1201–1203.

    Article  PubMed  Google Scholar 

  44. Gunduz, M. I., Gumus, B. H., & Sekuri, C. (2004). Relationship between metabolic syndrome and erectile dysfunction. Asian Journal of Andrology, 6(4), 355–358.

    CAS  PubMed  Google Scholar 

  45. Koseoglu, N., et al. (2005). Erectile dysfunction prevalence and sexual function status in patients with chronic obstructive pulmonary disease. Journal d’Urologie, 174(1), 249–252. Discussion 252.

    CAS  Google Scholar 

  46. Semple, P. D., et al. (1984). Sex hormone suppression and sexual impotence in hypoxic pulmonary fibrosis. Thorax, 39(1), 46–51.

    Article  CAS  PubMed  Google Scholar 

  47. Aasebo, U., et al. (1993). Reversal of sexual impotence in male patients with chronic obstructive pulmonary disease and hypoxemia with long-term oxygen therapy. The Journal of Steroid Biochemistry and Molecular Biology, 46(6), 799–803.

    Article  CAS  PubMed  Google Scholar 

  48. Lavie, P. (1983). Incidence of sleep apnea in a presumably healthy working population: A significant relationship with excessive daytime sleepiness. Sleep, 6(4), 312–318.

    CAS  PubMed  Google Scholar 

  49. Pressman, M. R., et al. (1986). Problems in the interpretation of nocturnal penile tumescence studies: Disruption of sleep by occult sleep disorders. Journal d’Urologie, 136(3), 595–598.

    CAS  Google Scholar 

  50. Margel, D., et al. (2004). Severe, but not mild, obstructive sleep apnea syndrome is associated with erectile dysfunction. Urology, 63(3), 545–549.

    Article  PubMed  Google Scholar 

  51. Fanfulla, F., et al. (2000). Erectile dysfunction in men with obstructive sleep apnea: An early sign of nerve involvement. Sleep, 23(6), 775–781.

    CAS  PubMed  Google Scholar 

  52. Akashiba, T., et al. (2002). Relationship between quality of life and mood or depression in patients with severe obstructive sleep apnea syndrome. Chest, 122(3), 861–865.

    Article  PubMed  Google Scholar 

  53. Lue, T. F. (2001). Neurogenic erectile dysfunction. Clinical Autonomic Research, 11(5), 285–294.

    Article  CAS  PubMed  Google Scholar 

  54. Papatsoris, A. G., et al. (2006). Erectile dysfunction in Parkinson’s disease. Urology, 67(3), 447–451.

    Article  CAS  PubMed  Google Scholar 

  55. Zeiss, A. M., et al. (1990). The incidence and correlates of erectile problems in patients with Alzheimer’s disease. Archives of Sexual Behavior, 19(4), 325–331.

    Article  CAS  PubMed  Google Scholar 

  56. Zorzon, M., et al. (1999). Sexual dysfunction in multiple sclerosis: A case-control study. I. Frequency and comparison of groups. Multiple Sclerosis, 5(6), 418–427.

    CAS  PubMed  Google Scholar 

  57. Demirkiran, M., et al. (2006). Multiple sclerosis patients with and without sexual dysfunction: Are there any differences? Multiple Sclerosis, 12(2), 209–214.

    Article  CAS  PubMed  Google Scholar 

  58. Kuba, R., et al. (2006). Sexual dysfunctions and blood hormonal profile in men with focal epilepsy. Epilepsia, 47(12), 2135–2140.

    Article  CAS  PubMed  Google Scholar 

  59. Toone, B. K., et al. (1989). Hyposexuality and epilepsy: A community survey of hormonal and behavioural changes in male epileptics. Psychological Medicine, 19(4), 937–943.

    Article  CAS  PubMed  Google Scholar 

  60. Smaldone, M., et al. (2004). Epilepsy and erectile dysfunction: A review. Seizure, 13(7), 453–459.

    Article  CAS  PubMed  Google Scholar 

  61. Geiger, R. C. (1980). Neurophysiology of sexual response in spinal cord injury. ARN Journal, 5(6), 16–19.

    CAS  PubMed  Google Scholar 

  62. Biering-Sorensen, F., & Sonksen, J. (2001). Sexual function in spinal cord lesioned men. Spinal Cord, 39(9), 455–470.

    Article  CAS  PubMed  Google Scholar 

  63. Korpelainen, J. T., Nieminen, P., & Myllyla, V. V. (1999). Sexual functioning among stroke patients and their spouses. Stroke, 30(4), 715–719.

    CAS  PubMed  Google Scholar 

  64. Bener, A., et al. (2008). Prevalence of erectile dysfunction in male stroke patients, and associated co-morbidities and risk factors. International Urology and Nephrology, 40(3), 701–708.

    Article  PubMed  Google Scholar 

  65. Jung, J. H., et al. (2008). Sexual dysfunction in male stroke patients: Correlation between brain lesions and sexual function. Urology, 71(1), 99–103.

    Article  PubMed  Google Scholar 

  66. Schrader, S. M., Breitenstein, M. J., & Lowe, B. D. (2008). Cutting off the nose to save the penis. The Journal of Sexual Medicine, 5(8), 1932–1940.

    Article  PubMed  Google Scholar 

  67. Dettori, J. R., et al. (2004). Erectile dysfunction after a long-distance cycling event: Associations with bicycle characteristics. Journal d’Urologie, 172(2), 637–641.

    Google Scholar 

  68. Taylor, J. A., III, et al. (2004). Bicycle riding and its relationship to the development of erectile dysfunction. Journal d’Urologie, 172(3), 1028–1031.

    Google Scholar 

  69. Mulhall, J. P. (2009). Defining and reporting erectile function outcomes after radical prostatectomy: Challenges and misconceptions. Journal d’Urologie, 181(2), 462–471.

    Google Scholar 

  70. Walsh, P. C., & Donker, P. J. (1982). Impotence following radical prostatectomy: Insight into etiology and prevention. Journal d’Urologie, 128(3), 492–497.

    CAS  Google Scholar 

  71. Montorsi, F., et al. (1997). Recovery of spontaneous erectile function after nerve-sparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil: Results of a prospective, randomized trial. Journal d’Urologie, 158(4), 1408–1410.

    CAS  Google Scholar 

  72. Glickman, L., Godoy, G., & Lepor, H. (2009). Changes in continence and erectile function between 2 and 4 years after radical prostatectomy. Journal d’Urologie, 181(2), 731–735.

    Google Scholar 

  73. Ferrini, M. G., et al. (2006). Vardenafil prevents fibrosis and loss of corporal smooth muscle that occurs after bilateral cavernosal nerve resection in the rat. Urology, 68(2), 429–435.

    Article  PubMed  Google Scholar 

  74. Lizza, E. F., & Rosen, R. C. (1999). Definition and classification of erectile dysfunction: Report of the Nomenclature Committee of the International Society of Impotence Research. International Journal of Impotence Research, 11(3), 141–143.

    Article  CAS  PubMed  Google Scholar 

  75. Sachs, B. D. (2003). The false organic-psychogenic distinction and related problems in the classification of erectile dysfunction. International Journal of Impotence Research, 15(1), 72–78.

    Article  PubMed  Google Scholar 

  76. Araujo, A. B., et al. (1998). The relationship between depressive symptoms and male erectile dysfunction: Cross-sectional results from the Massachusetts Male Aging Study. Psychosomatic Medicine, 60(4), 458–465.

    CAS  PubMed  Google Scholar 

  77. Kennedy, S. H., et al. (1999). Sexual dysfunction before antidepressant therapy in major depression. Journal of Affective Disorders, 56(2–3), 201–208.

    Article  CAS  PubMed  Google Scholar 

  78. Johnson, A. R., III, & Jarow, J. P. (1992). Is routine endocrine testing of impotent men necessary? Journal d’Urologie, 147(6), 1542–1543. Discussion 1543–1544.

    Google Scholar 

  79. Buvat, J., & Lemaire, A. (1997). Endocrine screening in 1,022 men with erectile dysfunction: Clinical significance and cost-effective strategy. Journal d’Urologie, 158(5), 1764–1767.

    CAS  Google Scholar 

  80. Kohler, T. S., et al. (2008). Prevalence of androgen deficiency in men with erectile dysfunction. Urology, 71(4), 693–697.

    Article  PubMed  Google Scholar 

  81. Traish, A. M., et al. (1999). Effects of castration and androgen replacement on erectile function in a rabbit model. Endocrinology, 140(4), 1861–1868.

    Article  CAS  PubMed  Google Scholar 

  82. Traish, A. M., et al. (2003). Effects of medical or surgical castration on erectile function in an animal model. Journal of Andrology, 24(3), 381–387.

    PubMed  Google Scholar 

  83. Harman, S. M., et al. (2001). Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. The Journal of Clinical Endocrinology and Metabolism, 86(2), 724–731.

    Article  CAS  PubMed  Google Scholar 

  84. Makhlouf, A. A., et al. (2008). Hypogonadism is associated with overt depression symptoms in men with erectile dysfunction. International Journal of Impotence Research, 20(2), 157–161.

    Article  CAS  PubMed  Google Scholar 

  85. Corona, G., et al. (2007). Effect of hyperprolactinemia in male patients consulting for sexual dysfunction. The Journal of Sexual Medicine, 4(5), 1485–1493.

    Article  CAS  PubMed  Google Scholar 

  86. Venetikou, M. S., Lambou, T., & Gizani, D. (2008). Hyperprolactinaemia due to hypothalamic-pituitary disease or drug-induced in patients with erectile dysfunction. Andrologia, 40(4), 240–244.

    Article  CAS  PubMed  Google Scholar 

  87. Henderson, H. L., Townsend, J., & Tortonese, D. J. (2008). Direct effects of prolactin and dopamine on the gonadotroph response to GnRH. The Journal of Endocrinology, 197(2), 343–350.

    Article  CAS  PubMed  Google Scholar 

  88. Grattan, D. R., et al. (2007). Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocrinology, 148(9), 4344–4351.

    Article  CAS  PubMed  Google Scholar 

  89. Page-Wilson, G., Smith, P. C., & Welt, C. K. (2006). Prolactin suppresses GnRH but not TSH secretion. Hormone Research, 65(1), 31–38.

    Article  CAS  PubMed  Google Scholar 

  90. Corona, G., et al. (2009). Hypoprolactinemia: A new clinical syndrome in patients with sexual dysfunction. The Journal of Sexual Medicine, 6(5), 1457–1466.

    Article  CAS  PubMed  Google Scholar 

  91. Krassas, G. E., et al. (2008). Erectile dysfunction in patients with hyper- and hypothyroidism: How common and should we treat? The Journal of Clinical Endocrinology and Metabolism, 93(5), 1815–1819.

    Article  CAS  PubMed  Google Scholar 

  92. Wortsman, J., Rosner, W., & Dufau, M. L. (1987). Abnormal testicular function in men with primary hypothyroidism. The American Journal of Medicine, 82(2), 207–212.

    Article  CAS  PubMed  Google Scholar 

  93. Medical Research Council Working Party (1981). Adverse reactions to bendrofluazide and propranolol for the treatment of mild hypertension. Report of Medical Research Council Working Party on Mild to Moderate Hypertension. Lancet, 2(8246), 539–543.

    Google Scholar 

  94. Dorevitch, A., & Davis, H. (1994). Fluvoxamine-associated sexual dysfunction. The Annals of Pharmacotherapy, 28(7–8), 872–874.

    CAS  PubMed  Google Scholar 

  95. Clayton, A., Keller, A., & McGarvey, E. L. (2006). Burden of phase-specific sexual dysfunction with SSRIs. Journal of Affective Disorders, 91(1), 27–32.

    Article  PubMed  Google Scholar 

  96. Wassertheil-Smoller, S., et al. (1991). Effect of antihypertensives on sexual function and quality of life: The TAIM Study. Annals of Internal Medicine, 114(8), 613–620.

    CAS  PubMed  Google Scholar 

  97. Grimm, R. H., et al. (1997). Long-term effects on sexual function of five antihypertensive drugs and nutritional hygienic treatment in hypertensive men and women. Treatment of Mild Hypertension Study (TOMHS). Hypertension, 29(1 Pt 1), 8–14.

    CAS  PubMed  Google Scholar 

  98. Cocco, G. (2009). Erectile dysfunction after therapy with metoprolol: The Hawthorne effect. Cardiology, 112(3), 174–177.

    Article  CAS  PubMed  Google Scholar 

  99. Lin, S. N., et al. (1988). Local suppressive effect of clonidine on penile erection in the dog. Journal d’Urologie, 139(4), 849–852.

    CAS  Google Scholar 

  100. Hogan, M. J., Wallin, J. D., & Baer, R. M. (1980). Antihypertensive therapy and male sexual dysfunction. Psychosomatics, 21(3), 234, 236–237.

    CAS  PubMed  Google Scholar 

  101. Do, C., et al. (2009). Statins and erectile dysfunction: Results of a case/non-case study using the French Pharmacovigilance System Database. Drug Safety, 32(7), 591–597.

    Article  CAS  PubMed  Google Scholar 

  102. Meltzer, H. Y. (1999). Treatment of schizophrenia and spectrum disorders: Pharmacotherapy, psychosocial treatments, and neurotransmitter interactions. Biological Psychiatry, 46(10), 1321–1327.

    Article  CAS  PubMed  Google Scholar 

  103. Knegtering, H., et al. (2008). Are sexual side effects of prolactin-raising antipsychotics reducible to serum prolactin? Psychoneuroendocrinology, 33(6), 711–717.

    Article  CAS  PubMed  Google Scholar 

  104. Moinpour, C. M., et al. (2007). Longitudinal analysis of sexual function reported by men in the Prostate Cancer Prevention Trial. Journal of the National Cancer Institute, 99(13), 1025–1035.

    Article  PubMed  Google Scholar 

  105. Hallinan, R., et al. (2008). Erectile dysfunction in men receiving methadone and buprenorphine maintenance treatment. The Journal of Sexual Medicine, 5(3), 684–692.

    Article  CAS  PubMed  Google Scholar 

  106. Mayhan, W. G., & Patel, K. P. (1997). Effect of nicotine on endothelium-dependent arteriolar dilatation in vivo. The American Journal of Physiology, 272(5 Pt 2), H2337–H2342.

    CAS  PubMed  Google Scholar 

  107. Chalon, S., et al. (2000). Nicotine impairs endothelium-dependent dilatation in human veins in vivo. Clinical Pharmacology and Therapeutics, 67(4), 391–397.

    Article  CAS  PubMed  Google Scholar 

  108. Harte, C. B., & Meston, C. M. (2008). Acute effects of nicotine on physiological and subjective sexual arousal in nonsmoking men: A randomized, double-blind, placebo-controlled trial. The Journal of Sexual Medicine, 5(1), 110–121.

    PubMed  Google Scholar 

  109. Shabsigh, R., et al. (1991). Cigarette smoking and other vascular risk factors in vasculogenic impotence. Urology, 38(3), 227–231.

    Article  CAS  PubMed  Google Scholar 

  110. Aydinoglu, F., et al. (2008). Effects of ethanol treatment on the neurogenic and endothelium-dependent relaxation of corpus cavernosum smooth muscle in the mouse. Pharmacological Reports, 60(5), 725–734.

    CAS  PubMed  Google Scholar 

  111. Korfage, I. J., et al. (2008). Does “normal” aging imply urinary, bowel, and erectile dysfunction? A general population survey. Urology, 72(1), 3–9.

    Article  PubMed  Google Scholar 

  112. Corona, G., et al. (2009). The age-related decline of testosterone is associated with different specific symptoms and signs in patients with sexual dysfunction. International Journal of Andrology, 32(6), 720–728.

    Google Scholar 

  113. Rowland, D. L., et al. (1989). Penile and finger sensory thresholds in young, aging, and diabetic males. Archives of Sexual Behavior, 18(1), 1–12.

    Article  CAS  PubMed  Google Scholar 

  114. Rosas, S. E., et al. (2001). Prevalence and determinants of erectile dysfunction in hemodialysis patients. Kidney International, 59(6), 2259–2266.

    CAS  PubMed  Google Scholar 

  115. Procci, W. R., et al. (1981). Sexual dysfunction in the male patient with uremia: A reappraisal. Kidney International, 19(2), 317–323.

    Article  CAS  PubMed  Google Scholar 

  116. Joven, J., et al. (1985). Hormonal profile and serum zinc levels in uraemic men with gonadal dysfunction undergoing haemodialysis. Clinica Chimica Acta, 148(3), 239–245.

    Article  CAS  Google Scholar 

  117. Prem, A. R., et al. (1996). Male reproductive function in uraemia: Efficacy of haemodialysis and renal transplantation. British Journal of Urology, 78(4), 635–638.

    CAS  PubMed  Google Scholar 

  118. Yadav, R., et al. (2008). A prospective analysis of testicular androgenic function in recipients of a renal allograft. International Urology and Nephrology, 40(2), 397–403.

    Article  CAS  PubMed  Google Scholar 

  119. Mahajan, S. K., et al. (1982). Effect of oral zinc therapy on gonadal function in hemodialysis patients. A double-blind study. Annals of Internal Medicine, 97(3), 357–361.

    CAS  PubMed  Google Scholar 

  120. Braun, M., et al. (2000). Epidemiology of erectile dysfunction: Results of the ‘Cologne Male Survey’. International Journal of Impotence Research, 12(6), 305–311.

    Article  CAS  PubMed  Google Scholar 

  121. Shiri, R., et al. (2005). Effect of lower urinary tract symptoms on the incidence of erectile dysfunction. Journal d’Urologie, 174(1), 205–209. Discussion 209.

    Google Scholar 

  122. Mondul, A. M., et al. (2008). A prospective study of lower urinary tract symptoms and erectile dysfunction. Journal d’Urologie, 179(6), 2321–2326.

    Google Scholar 

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  1. Department of Urology, Case Medical Center/University Hospitals of Cleveland, 3530 Boynton Road, Cleveland, OH, 44121, USA

    Lauren N. Byrne

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  1. Lauren N. Byrne
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  1. Feinberg School of Medicine, Department of Urology, Northwestern University, East Chicago Avenue 303, Chicago, 60611-3008, Illinois, USA

    Kevin T. McVary

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© 2011 Springer Science+Business Media, LLC

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Byrne, L.N., Avila, D., Seftel, A.D., Khera, M., Parikh, P.T. (2011). Etiology and Risk Factors of Erectile Dysfunction. In: McVary, K. (eds) Contemporary Treatment of Erectile Dysfunction. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-60327-536-1_5

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  • DOI: https://doi.org/10.1007/978-1-60327-536-1_5

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