Skip to main content

Prosthetic Joint Infections in Elderly Patients

  • Chapter
  • First Online:
Infectious Disease in the Aging

Part of the book series: Infectious Disease ((ID))

  • 1003 Accesses

Abstract

Although prosthetic joint infections (PJIs) occur in a small proportion of patients following total joint arthroplasty, they have catastrophic consequences on morbidity and joint function and carry a high economic burden in the elderly patients.

Clinical presentation of prosthetic joint infection is highly variable, and differentiating a painful joint arthroplasty secondary to mechanical loosening from an indolent infection can be difficult.

There is no “gold standard” for diagnosis of a prosthetic joint infection. The diagnosis may be challenging, and current definitions used by clinicians are derived from multiple sources of information.

The management of prosthetic joint infection is complex. The goals of therapy are to cure or control the infection, prevent its recurrence, improve or preserve functional status and reduce the risk of death.

Multiple surgeries and prolonged course of antimicrobial therapy may be needed to accomplish these treatment goals. Close collaboration between the orthopedic surgeon and the Infectious Diseases specialist is essential for achieving those goals.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Trampuz, A., Osmon, D.R., Hanssen, A.D., et al. (2003). Molecular and antibiofilm approaches to prosthetic joint infection. Clinical Orthopaedics and Related Research, 414, 69–88.

    Article  PubMed  Google Scholar 

  2. Kurtz, S., Ong, K., Lau, E.M., et al. (2007). Projections of primary and revision hip and knee arthroplasty in the united states from 2005 to 2030. The Journal of Bone and Joint Surgery. American Volume, 89(4), 780–785.

    Article  PubMed  Google Scholar 

  3. Zhang, C., Kaczmarek, R., Loyo-Berrios, N., et al., (2007). Incidence and short-term outcomes of primary and revision hip replacement in the United States. The Journal of Bone and Joint Surgery. American Volume, 89(3), 526–533.

    Article  Google Scholar 

  4. Zimmerli, W., Trampuz, A., Ochsner, P.E. (2004). Prosthetic-joint infections. The New England Journal of Medicine, 351(16), 1645–1654.

    Article  PubMed  CAS  Google Scholar 

  5. Sculco, T.P. (1995). The economic impact of infected joint arthroplasty. Orthopedics, 18, 871–873.

    PubMed  CAS  Google Scholar 

  6. Hanssen, A.D., Rand, J.A. (1999). Evaluation and treatment of infection at the site of a total hip or knee arthroplasty. Instructional Course Lectures, 48, 111–122.

    PubMed  CAS  Google Scholar 

  7.  7. Lidgren, L., Knutson, K., Stefansdottir, A. (2003). Infection and arthritis Infection of prosthetic joints. Best Practice & Research. Clinical Rheumatology, 17(2), 209–218.

    Article  Google Scholar 

  8. Sperling, J.W., Kozak, T.K., Hanssen, A.D., et al. (2001). Infection after shoulder arthroplasty. Clinical Orthopaedics and Related Research, 382, 206–216.

    Article  PubMed  Google Scholar 

  9. Sia, I.G., Berbari, E.F., Karchmer, A.W. (2005). Prosthetic joint infections. Infectious Disease Clinics of North America, 19(4), 885–914.

    Article  PubMed  Google Scholar 

  10. Bengston, S., Knutson, K. (1991). The infected arthroplasty: A 6-year follow-up of 357 cases. Acta orthopaedica Scandinavica, 62, 301–311.

    Article  Google Scholar 

  11. Berbari, E.F., Hanssen, A.D., Duffy, M.C., et al. (1998). Risk factors for prosthetic joint infection: Case-control study. Clinical Infectious Diseases, 27(5), 1247–1254.

    Article  PubMed  CAS  Google Scholar 

  12. Maderazo, E.G., Judson, S., Pasternak, H., et al. (1988). Late infections of total joint prostheses: A review and recommendations for prevention. Clinical Orthopaedics and Related Research, 229, 131–142.

    PubMed  Google Scholar 

  13. Deacon, J.M., Pagliaro, A.J., Zelicof, S., et al. (1996). Prophylactic use of antibiotics for procedures after total joint replacement. The Journal of Bone and Joint Surgery. American Volume, 78, 1755–1770.

    PubMed  CAS  Google Scholar 

  14. Rubin, R., Salvati, E.A., Lewis, R., et al. (1976). Infected total hip replacement after dental procedures. Oral Surgery, Oral Medicine, and Oral Pathology, 41(1), 18–23.

    Article  PubMed  CAS  Google Scholar 

  15. Hanssen, A.D., Osmon, D.R., Nelson, C.L., et al. (1997). Prevention of deep periprosthetic infection. Instructional Course Lectures, 46, 555–567.

    PubMed  CAS  Google Scholar 

  16. Osmon, D.R., Hanssen, A.D., Patel. R., et al. (2005). Prosthetic joint infection: Criteria for future definitions. Clinical Orthopaedics and Related Research, 437, 89–90.

    Article  PubMed  Google Scholar 

  17. Spangehl, M.J., Masri, B.A., O’Connell, J.X. et al. (1999). Prospective analysis of preoperative and intraoperative investigations for the diagnosis of infection at the sites of two hundred and two revision total hip arthroplasties. The Journal of Bone and Joint Surgery. American Volume, 81(5), 672–683.

    PubMed  CAS  Google Scholar 

  18. Sanzen, L., Sundberg, M. (1997). Periprosthetic low-grade hip infections: Erythrocyte sedimentation rate and c-reactive protein in 23 cases. Acta orthopaedica Scandinavica, 68(5), 461–465.

    Article  PubMed  CAS  Google Scholar 

  19. Tsukayama, D.T., Estrada, R., Gustilo, R.B., et al. (1996). Infection after total hip arthroplasty: A study of the treatment of one hundred and six infections. The Journal of Bone and Joint Surgery. American Volume, 78(4), 512–523.

    PubMed  CAS  Google Scholar 

  20. Bernard, L., Lubbeke, A., Stern, R., et al. (2004). Value of preoperative investigations in diagnosing prosthetic joint infection: Retrospective cohort study and literature review. Scandinavian Journal of Infectious Diseases, 36(6–7), 410–416.

    Article  PubMed  Google Scholar 

  21. Bottner, F., Wegner, A., Winkelmann, W., et al. (2007). Interleukin-6, procalcitonin and TNF-alpha: Markers of peri-prosthetic infection following total joint replacement. The Journal of Bone and Joint Surgery. British Volume, 89(1), 94–99.

    Article  PubMed  CAS  Google Scholar 

  22. Trampuz, A., Hanssen, A.D., Osmon, D.R., et al. (2004). Synovial fluid leukocyte count and differential for the diagnosis of prosthetic knee infection. The American Journal of Medicine, 117(8), 556–562.

    Article  PubMed  Google Scholar 

  23. Cuckler, J.M., Star, A.M., Alavi, A., et al. (1991). Diagnosis and management of the infected total joint arthroplasty. The Orthopedic Clinics of North America, 22(3), 523–530.

    PubMed  CAS  Google Scholar 

  24. Love, C., Palestro, C.J. (2004). Radionuclide imaging of infection. Journal of Nuclear Medicine Technology, 32(2), 47–57, quiz 58–59.

    PubMed  Google Scholar 

  25. Garvin, K.L., Urban, J.A. (2003). Total hip infections. In J.H. Calhoun, J.T. Mader, (Eds.) Musculoskeletal infections. New York: Marcel Dekker; 241–291.

    Google Scholar 

  26. Johnson, J.A., Christie, M.J., Sandler, M.P., et al. (1988). Detection of occult infection following total joint arthroplasty using sequential technetium-99m hdp bone scintigraphy and indium-111 WBC imaging. 26. Journal of Nuclear Medicine, 29(8), 1347–1353.

    CAS  Google Scholar 

  27. Palestro, C.J., Kim, CK., Swyer, A.J., et al. (1990). Total-hip arthroplasty: Periprosthetic indium-111-labeled leukocyte activity and complementary technetium-99m-sulfur colloid imaging in suspected infection. [see comment]. Journal of Nuclear Medicine, 31(12), 1950–1955.

    PubMed  CAS  Google Scholar 

  28. Teller, R.E., Christie, M.J., Martin, W., et al. (2000). Sequential indium-labeled leukocyte and bone scans to diagnose prosthetic joint infection. Clinical Orthopaedics and Related Research, 373, 241–247.

    Article  PubMed  Google Scholar 

  29. Love, C., Marwin, S.E., Tomas, M.B., et al. (2004). Diagnosing infection in the failed joint replacement: A comparison of coincidence detection 18f-fdg and 111in-labeled leukocyte/99mtc-sulfur colloid marrow imaging. Journal of Nuclear Medicine, 45(11), 1864–1871.

    PubMed  Google Scholar 

  30. Sampedro, M.F., Patel, R. (2007). Infections associated with long-term prosthetic devices. Infectious Disease Clinics of North America, 21(3), 785–819.

    Article  PubMed  Google Scholar 

  31. Palestro, C.J. (2003). Nuclear medicine, the painful prosthetic joint, and orthopedic infection. Journal of Nuclear Medicine, 44(6), 927–929.

    PubMed  Google Scholar 

  32. Barrack, RL., Jennings, R.W., Wolfe, M.W., et al. (1997). The value of preoperative aspiration before total knee revision. Clinical Orthopaedics, 345, 8–16.

    Article  Google Scholar 

  33. Spangehl, M.J., Masterson, E., Masri, BA., et al. (1999). The role of intraoperative gram stain in the diagnosis of infection during revision total hip arthroplasty. The Journal of Arthroplasty, 14(8), 952–956.

    Article  PubMed  CAS  Google Scholar 

  34. Atkins, B.L., Athanasou, N., Deeks, J.J., et al. (1998). Prospective evaluation of criteria for microbiological diagnosis of prosthetic-joint infection at revision arthroplasty The osiris collaborative study group. The Journal of Bone and Joint Surgery. British Volume, 36(10), 2932–2939.

    CAS  Google Scholar 

  35. Chimento, G.F., Finger, S., Barrack, R.L., et al. (1996). Gram stain detection of infection during revision arthroplasty. The Journal of Bone and Joint Surgery. British Volume, 78, 838–839.

    PubMed  CAS  Google Scholar 

  36. Steckelberg, J.M., Osmon, D.R. (2000). Prosthetic joint infections. In A.L. Bisno, F.A. Waldwogel (Eds). Infections of Indwelling Prosthetic Devices. Washington, DC: ASM 173–209.

    Google Scholar 

  37. Berbari, E.F., Steckelberg, J.M., Osmon, D.R., et al. (2005). Osteomyelitis. In: G.L. Mandell, J.E. Bennett, R. Dollin (Eds.) Mandell, Douglas and Bennett’s Principles and Practice of infectious Disease 6th ed, Vol II. Philadelphia: Elsevier 1322–1332.

    Google Scholar 

  38. Kamme, C., Lindberg, L. (1981). Aerobic and anaerobic bacteria in deep infections after total hip arthroplasty: Differential diagnosis between infectious and noninfectious loosening. Clinical Orthopaedics, 154, 201–207.

    Google Scholar 

  39. Mackowiak, P.A., Jones, S.R., Smith, J.W., et al. (1978). Diagnostic value of sinus-tract cultures in chronic osteomyelitis. JAMA: The Journal of the American Medical Association, 239(26), 2772–2775.

    Article  CAS  Google Scholar 

  40. Fihman, V., Hannouche, D., Bousson, V., et al. (2007). Improved diagnosis specificity in bone and joint infections using molecular techniques. Journal of Infection, 55, 510–517.

    Article  PubMed  CAS  Google Scholar 

  41. Trampuz, A., Piper, K.E., Jacobson, M.J., et al. (2007). Sonication of removed hip and knee prostheses for diagnosis of infection [see comment]. The New England Journal of Medicine, 357(7), 654–663.

    Article  PubMed  CAS  Google Scholar 

  42. Lonner, J.H., Desai, P., Dicesare, P.E., et al. (1996). The reliability of analysis of intraoperative frozen sections for identifying active infection during revision hip or knee arthroplasty. The Journal of Bone and Joint Surgery. American Volume, 78, 1553–1558.

    PubMed  CAS  Google Scholar 

  43. Pace, T.B., Jeray, K.J., Latham, J.T.J., et al. (1997). Synovial tissue examination by frozen section as an indicator of infection in hip and knee arthroplasty in community hospitals. The Journal of Arthroplasty, 12, 64–69.

    Article  PubMed  CAS  Google Scholar 

  44. Trampuz, A., Widmer, A.F. (2006). Infections associated with orthopedic implants. Current Opinion in Infectious Diseases, 19, 349–356.

    Article  PubMed  CAS  Google Scholar 

  45. Fisman, D.N., Reilly, D.T., Karchmer, A.W., et al. (2001). Clinical effectiveness and cost effectiveness of 2 management strategies for infected total hip arthroplasty in the elderly. Clinical Infectious Diseases, 32, 419–430.

    Article  PubMed  CAS  Google Scholar 

  46. Zimmerli, W., Widmer, A.F., Blatter M., et al. (1998). Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: A randomized controlled trial. Foreign-body infection (fbi) study group [see comment]. JAMA: The Journal of the American Medical Association, 279(19), 1537–1541.

    Article  CAS  Google Scholar 

  47. Segawa, H., Tsukayama, D.T., Kyle, R.F., et al. (1999). Infection after total knee arthroplasty: A retrospective study of the treatment of eighty-one infections. The Journal of Bone and Joint Surgery. American Volume, 81(10), 1434–1445.

    PubMed  CAS  Google Scholar 

  48. Teeny, S.M., Dorr, L., Murata, G., et al. (1990). Treatment of infected knee arthroplasty: Irrigation and debridement versus two-stage reimplantation. The Journal of Arthroplasty, 5, 35–39.

    Article  PubMed  CAS  Google Scholar 

  49. Tattevin, P., Cremieux, A.C., Pottier, P., et al. (1999). Prosthetic joint infection: When can prosthesis salvage be considered? Clinical Infectious Diseases, 29(2), 292–295.

    Article  PubMed  CAS  Google Scholar 

  50. Brandt, C.M., Sistrunk, W.W., Duffy, M.C., et al. (1997). Staphylococcus aureus prosthetic joint infection treated with debridement and prosthesis retention. Clinical Infectious Diseases, 24(5), 914–919.

    Article  PubMed  CAS  Google Scholar 

  51. Marculescu, C.E., Berbari, E.F., Hanssen, A.D., et al. (2006). Outcome of prosthetic joint infections treated with debridement and retention of components. Clinical Infectious Diseases, 42(4), 471–478.

    Article  PubMed  CAS  Google Scholar 

  52. Meehan, A.M., Osmon, D.R., Duffy, M.C.T., et al. (2003). Outcome of penicillin-susceptible streptococcal prosthetic joint infection treated with debridement and retention of the prosthesis. Clinical Infectious Diseases, 36(7), 845–849.

    Article  PubMed  CAS  Google Scholar 

  53. Crockarell, J.R., Hanssen, A.D., Osmon, D.R., et al. (1998). Treatment of infection with debridement and retention of the components following hip arthroplasty. The Journal of Bone and Joint Surgery. American Volume, 80(9), 1306–1313.

    PubMed  CAS  Google Scholar 

  54. Drancourt, M., Stein, A., Argenson, J.N., et al. (1993). Oral rifampin plus ofloxacin for treatment of Staphylococcus-infected orthopedic implants. Antimicrobial Agents and Chemotherapy, 37, 1214–1218.

    PubMed  CAS  Google Scholar 

  55. Segreti, J., Nelson, J.A., Trenholme, G.M., et al. (1998). Prolonged suppressive antibiotic therapy for infected orthopedic prostheses [see comment]. Clinical Infectious Diseases, 27(4), 711–713.

    Article  PubMed  CAS  Google Scholar 

  56. Tsukayama, D.T., Wicklund, B., Gustilo, R.B., et al. (1991). Suppressive antibiotic therapy in chronic prosthetic joint infections. Orthopedics, 14(8), 841–844.

    PubMed  CAS  Google Scholar 

  57. Burger, R.R., Basch, T., Hopson, CN., et al. (1991). Implant salvage in infected total knee arthroplasty. Clinical Orthopaedics, 273, 105–112.

    Google Scholar 

  58. Rasul, A.T., Tsukayama, D.T., Gustilo, R.B., et al. (1991). Effect of time of onset and depth of infection on the outcome of total knee arthroplasty infections. Clinical Orthopaedics, 273, 98–104.

    Google Scholar 

  59. Schoifet, S.D., Morrey, B.F. (1990). Treatment of infection after total knee arthroplasty by debridement with retention of the components. The Journal of Bone and Joint Surgery. American Volume, 72, 1383–1390.

    PubMed  CAS  Google Scholar 

  60. Soriano, A., Garcia, S., Ortega, M., et al. (2003). Treatment of acute infection of total or partial hip arthroplasty with debridement and oral chemotherapy. Medicina clinica,121, 81–85.

    Article  PubMed  Google Scholar 

  61. Waldman, B.J., Hostin, E., Mont, M.A., et al. (2000). Infected total knee arthroplasty treated by arthroscopic irrigation and debridement. The Journal of Arthroplasty, 15, 430–436.

    Article  PubMed  CAS  Google Scholar 

  62. Buchholz, H.W., Elson, R.A., Elgelbrecht, E., et al. (1981). Management of deep infection of total hip replacement. The Journal of Bone and Joint Surgery. British Volume, 63(B), 342–353.

    PubMed  Google Scholar 

  63. Hope, P.G., Kristinsson, K.G., Norman, P., et al. (1989). Deep infection of cemented total hip arthroplasties caused by coagulase-negative staphylococci. The Journal of Bone and Joint Surgery. British Volume, 71, 851–855.

    PubMed  CAS  Google Scholar 

  64. Buechel, F.F., Femino, F.P., D’Alessio, J., et al. (2004). Primary exchange revision arthroplasty for infected total knee replacement: A long term study. The American Journal of Orthopedics, 33, 190–198.

    PubMed  Google Scholar 

  65. Callaghan, J.J., Katz, R.P., Johnston, R.C., et al. (1999). One-stage revision surgery of the infected hip: A minumum 10-year followup study. The Journal of Bone and Joint Surgery. American Volume, 369, 139–143.

    Google Scholar 

  66. Carlsson, A.S., Josefsson, G., Lindberg, L., et al. (1978). Revision with gentamicin-impregnated cement for deep infections in total hip arthroplasties. The Journal of Bone and Joint Surgery. American Volume, 60, 1059–1064.

    PubMed  CAS  Google Scholar 

  67. Freeman, M.A., Sudlow, R.A., Casewell, M.W., et al. (1985). The management of infected total knee replacements. The Journal of Bone and Joint Surgery. British Volume, 67, 764–768.

    PubMed  CAS  Google Scholar 

  68. Goksan, S.B., Freeman, M.A. (1992). One-stage reimplantation for infected total knee arthroplasty. The Journal of Bone and Joint Surgery. British Volume, 74, 78–82.

    PubMed  CAS  Google Scholar 

  69. Raut, V.V., Siney, P.D., Wrobleski, B.M., et al. (1994). One-stage revision of infected total hip replacements with discharging sinuses. The Journal of Bone and Joint Surgery. British Volume, 76(5), 721–724.

    PubMed  CAS  Google Scholar 

  70. Ure, K.J., Amstutz, H.C., Nasser, S., et al. (1998). Direct-exchange arthroplasty for the treatment of infection after total hip replacement: An average ten-year follow-up. The Journal of Bone and Joint Surgery. American Volume, 80(7), 961–968.

    PubMed  CAS  Google Scholar 

  71. Hughes, P.W., Salvati, E.A., Wilson, P.D., et al. (1979). Treatment of subacute sepsis of the hip by antibiotics and joint replacement criteria for diagnosis with evaluation of twenty-six cases. Clinical Orthopaedics, 141, 143–157.

    Google Scholar 

  72. Wilde, A.H. (1994). Management of infected knee and hip prostheses. Current Opinion in Rheumatology, 6, 172–176.

    Article  PubMed  CAS  Google Scholar 

  73. Trampuz, A., Zimmerli, W. (2005). Prosthetic joint infections: Update in diagnosis and treatment. Swiss Medical Weekly, 135(17–18), 243–251.

    PubMed  Google Scholar 

  74. Haddad, F.S., Muirhead-Allwood, S.K., Manktelow, A.R., et al. (2000). Two-stage uncemented revision hip arthroplasty for infection. The Journal of Bone and Joint Surgery. British Volume, 82, 689–694.

    Article  PubMed  CAS  Google Scholar 

  75. Fehring, T.K., Calton, T.F., Griffin, W.L., et al. (1999). Cementless fixation in 2-stage reimplantation for periprosthetic sepsis. The Journal of Arthroplasty, 14, 175–181.

    Article  PubMed  CAS  Google Scholar 

  76. Rand, J.A., Bryan, R.S. (1983). Reimplantation for the salvage of an infected total knee arthroplasty. The Journal of Bone and Joint Surgery. American Volume, 65, 1081–1086.

    Google Scholar 

  77. Hirakawa, K., Stulberg, B.N., Wilde, A.H., et al. (1998). Results of 2-stage reimplantation for infected total knee arthroplasty. The Journal of Arthroplasty, 13(1), 22–28.

    Article  PubMed  CAS  Google Scholar 

  78. Hanssen, A.D., Rand, J.A., Osmon, D.R., et al. (1994). Treatment of the infected total knee arthroplasty with insertion of another prosthesis: The effect of antibiotic-impregnated bone cement. Clinical Orthopaedics, 309, 44–55.

    Google Scholar 

  79. Mont, M.A., Waldman, B.J., Hungerford, D.S., et al. (2000). Evaluation of preoperative cultures before second-stage reimplantation of a total knee prosthesis complicated by infection: A comparison-group study. The Journal of Bone and Joint Surgery. American Volume, 82-A(11), 1552–1557.

    PubMed  CAS  Google Scholar 

  80. Donati, D., Biscaglia, R. (1998). The use of antibiotic-impreganted cement in infected reconstructions, after resection for bone tumours. The Journal of Bone and Joint Surgery, 80, 1045–1050.

    Article  PubMed  CAS  Google Scholar 

  81. Ozaki, T., Yoshitaka, T., Kunisada, T., et al. (1998). Vancomycin-impregnated polymethylmethacrylate beads for methicillin-resistant Staphylococcus aureus (MRSA) infection: Report of two cases. Journal of Orthopaedic Science, 3, 161–168.

    Article  Google Scholar 

  82. Anguita-Alonso, P., Hanssen, A.D., Osmon, D.R., et al. (2005). High rate of aminoglycoside resistance among staphylococci causing prosthetic joint infection. Clinical Orthopaedics and Related Research, 439, 43–47.

    Article  PubMed  Google Scholar 

  83. Anguita-Alonso, P., Rouse, M.S., Piper, K.E., et al. (2006). Comparative study of antimicrobial release kinetics from polymethylmethacrylate. Clinical Orthopaedics and Related Research, 445, 239–244.

    PubMed  Google Scholar 

  84. Canner, G.C., Steinberg, M.E., Heppenstall, R.B., et al. (1984). The infected hip after total hip arthroplasty. The Journal of Bone and Joint Surgery. American Volume, 66, 1393–1399.

    PubMed  CAS  Google Scholar 

  85. Kantor, G.S., Osterkamp, J.A., Dorr, L.D., et al. (1986). Resection arthroplasty following infected total hip replacement arthroplasty. The Journal of Arthroplasty, 1, 83–89.

    Article  PubMed  CAS  Google Scholar 

  86. Grauer, J.D., Amsturz, H.C., O’Carroll, P.F., et al. (1989). Resection arthroplasty of the hip. The Journal of Bone and Joint Surgery. American Volume, 71, 669–678.

    CAS  Google Scholar 

  87. McElwaine, J.P., Collville, J. (1984). Excision arthroplasty for infected total hip replacements. The Journal of Bone and Joint Surgery. British Volume, 66, 168–171.

    PubMed  CAS  Google Scholar 

  88.  88. Bittar, E.S., Petty, W. (1982). Girdlestone arthroplasty for infected total hip arthroplasty. Clinical Orthopaedics, 170, 83–87.

    Google Scholar 

  89.  89. Falahee, M.H., Matthews, L.S., Kaufer, H., et al. (1987). Resection arthroplasty as a salvage procedure for a knee with infection after a total arthroplasty. The Journal of Bone and Joint Surgery. American Volume, 69, 1013–1021.

    PubMed  CAS  Google Scholar 

  90.  90. Gillespie, W.J. (1997). Prevention and management of infection after total joint replacement. Clinical Infectious Diseases, 25, 1310–1317.

    CAS  Google Scholar 

  91.  91. Benson, E.R., Resine, S.T., Lewis, C.G., et al. (1998). Functional outcome of arthrodesis for failed total knee arthroplasty. Orthopedics, 21, 875–879.

    PubMed  CAS  Google Scholar 

  92.  92. Isiklar, Z.U., Landon, G.C., Tullos, H.S., et al. (1994). Amputation after failed total knee arthroplasty. Clinical Orthopaedics, 299, 173–178.

    Google Scholar 

  93.  93. Sierra, R.J., Trousdale, R.T., Pagnano, M.W., et al. (2003). Above-the-knee amputation after a total knee replacement: Prevalence, etiology, and functional outcome. The Journal of Bone and Joint Surgery. American Volume, 85, 1000–1004.

    Google Scholar 

  94.  94. Osmon, D.R., Berbari, E.F. (2002). Outpatient intravenous antimicrobial therapy for the practicing orthopaedic surgeon. Clinical Orthopaedics and Related Research, 403, 80–86.

    Article  PubMed  Google Scholar 

  95.  95. Chuard, C., Vaudaux, P., Waldvogel, F.A., et al. (1993). Susceptibility of Staphylococcus aureus growing on fibronectin-coated surfaces to bactericidal antibiotics. Antimicrobial Agents and Chemotherapy, 37(4), 625–632.

    PubMed  CAS  Google Scholar 

  96.  96.Chuard, C., Herrmann, M., Vaudaux, P., et al. (1991).Successful therapy of experimental chronic foreign-body infection due to methicillin-resistant Staphylococcus aureus by antimicrobial combinations. Antimicrobial Agents and Chemotherapy, 35(12), 2611–2616.

    PubMed  CAS  Google Scholar 

  97.  97. Salgado, C.D., Dash, S., Robert Cantey, J., et al. (2007). Marculescu CE. Higher risk of failure of methicillin-resistant Staphylococcus aureus prosthetic joint infections. Clinical Orthopaedics and Related Research, 461, 48–53.

    PubMed  Google Scholar 

  98. Moise-Broder, P.A., Sakoulas, G., Eliopoulos, G.M., et al. (2004). Accessory gene regulator group ii polymorphism in methicillin-resistant Staphylococcus aureus is predictive of failure of vancomycin therapy [see comment]. Clinical Infectious Diseases, 38(12), 1700–1705.

    Article  PubMed  CAS  Google Scholar 

  99. Rao, N., Ziran, B.H., Hall, R.A., et al. (2004). Successful treatment of chronic bone and joint infections with oral linezolid. Clinical Orthopaedics and Related Research, 427, 67–71.

    Article  PubMed  Google Scholar 

  100. Razonable, R.R., Osmon, D.R., Steckelberg, J.M., et al. (2004). Linezolid therapy for orthopedic infections. Mayo Clinic Proceedings, 79(9), 1137–1144.

    PubMed  CAS  Google Scholar 

  101. Rayner, C.R., Baddour, L.M., Birmingham, M.C., et al. (2004). Linezolid in the treatment of osteomyelitis: Results of compassionate use experience. Infection, 32(1), 8–14.

    Article  PubMed  CAS  Google Scholar 

  102. Finney, M.S., Crank, C.W., Segreti, J., et al. (2005). Use of daptomycin to treat drug-resistant gram-positive bone and joint infections. Current Medical Research and Opinion, 21(12), 1923–1926.

    Article  PubMed  CAS  Google Scholar 

  103. Rao, N., Regalla, D.M. (2006). Uncertain efficacy of daptomycin for prosthetic joint infections: A prospective case series. Clinical Orthopaedics and Related Research, 451, 34–37

    Article  PubMed  Google Scholar 

  104. Yin, L-Y., Lazzarini, L., Li, F., et al. (2005). Comparative evaluation of tigecycline and vancomycin, with and without rifampicin, in the treatment of methicillin-resistant Staphylococcus aureus experimental osteomyelitis in a rabbit model. The Journal of Antimicrobial Chemotherapy, 55(6), 995–1002.

    Article  PubMed  CAS  Google Scholar 

  105. Rao, N., Crossett, L.S., Sinha, R.K., et al. (2003). Long-term suppression of infection in total joint arthroplasty. Clinical Orthopaedics and Related Research, 414, 55–60.

    Article  PubMed  Google Scholar 

  106. Goulet, J.A., Pellicci, P.M., Brause, B.D., et al. (1988). Prolonged suppression of infection in total hip arthroplasty. The Journal of Arthroplasty, 3(2), 109–116.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Douglas R. Osmon .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Humana Press, a part of Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Marculescu, C.E., Berbari, E.F., Osmon, D.R. (2009). Prosthetic Joint Infections in Elderly Patients. In: Norman, D., Yoshikawa, T. (eds) Infectious Disease in the Aging. Infectious Disease. Humana Press. https://doi.org/10.1007/978-1-60327-534-7_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-60327-534-7_20

  • Published:

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-533-0

  • Online ISBN: 978-1-60327-534-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics