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Infection or Inflammation and ICU Seizures

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Seizures in Critical Care

Part of the book series: Current Clinical Neurology ((CCNEU))

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Abstract

Effective treatment of seizures associated with CNS infection and inflammation depends on rapid diagnosis and early attainment of bactericidal activity within the CSF with appropriate antimicrobial agents, or appropriate management of vasculitis-induced cerebral complications. There is nothing specific regarding the management of ICU seizures in these situations, except for a high suspicion by the medical staff, as seizures are not uncommon in this setting. Improvement in long-term neurologic outcome depends on both the therapy of the infectious/inflammatory process and the intensive care multisystem monitoring commonly warranted in this patient population. The primary goal of preserving CNS function is shared by both the neurologist and the intensivist, making a multidisciplinary approach essential.

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References

  1. Tyler KL (2004) Herpes Simplex infections of the central nervous system: encephalitis and meningitis, including Mollaret’s. Herpes 11(Suppl 2):57A–67A

    PubMed  Google Scholar 

  2. Van De Beek D, De Gans J, Spanjaard L, Weisfelt M, Reistma JB, Vermeurlen M (2004) Clinical features and prognostic factors in bacterial meningitis. N Engl J Med 351(18):1849–1859

    PubMed  Google Scholar 

  3. Whitley RJ, Soong SJ, Linneman C Jr, Liu C, Pazin G, Alford CA (1982) Herpes Simplex encephalitis: clinical assessment. JAMA 247(3):317–320

    PubMed  CAS  Google Scholar 

  4. Wang KW, Chang WN, Chang HW et al (2005) The significance of seizures and other predictive factors during the acute illness for the long-term outcome after bacterial meningitis. Seizure 14(8):586–592

    PubMed  Google Scholar 

  5. Aronin SI, Peduzzi P, Quagliarello VJ (1998) Community-acquired bacterial meningitis: risk stratification for adverse clinical outcomes and effect of antibiotic timing. Ann Intern Med 129(11):862–869

    PubMed  CAS  Google Scholar 

  6. Bleck TP, Smith MC, Pierre-Louis SJC, Jares JJ, Murray J, Hansen C (1993) Neurologic compications of critical medical illnesses. Crit Care Med 21:98–103

    PubMed  CAS  Google Scholar 

  7. Classen J, Mayer SA, Kowalski RG, Emerson RG, Hirsch LJ (2004) Detection of electrographic seizures with continious EEG monitoring in critically ill patients. Neurology 62(10):1743–1748

    Google Scholar 

  8. Claassen J, Jette N, Chum F et al (2007) Predictors and significance of electrographic seizures and periodic discharges after intracerebral hemorrhage. Neurology 69(13):1356–1365

    PubMed  CAS  Google Scholar 

  9. Claasen J, Hirsch LJ, Frontera JA et al (2006) Prognostic significance of continious EEG monitoring in patients with poor-grade subarachnoid hemorrhage. Neuro Crit Care 4(2):103–112

    Google Scholar 

  10. Van De Beek D, De Gans J, Tunkel AR, Wijdicks EF (2006) Community-acquired bacterial meningitis in adults. N Engl J Med 354(1)L:44–53

    Google Scholar 

  11. Carrera E, Claassen J, Oddo M, Emerson RG, Mayer S, Hirsch LJ (2008) Continuous electrographic monitoring in critically ill patients with central nervous system infections. Arch Neurology 65(12):1612–1618

    Google Scholar 

  12. Coyle P (1999) Overview of acute and chronic meningitis. In: Marra CA (ed) Neurologic clinics: central nervous system infections, vol 17. W.B. Saunders Company, Philadelphia, pp 691–710

    Google Scholar 

  13. Townsend G, Shield W (1998) Infections of the central nervous system. Adv Intern Med 43:403–447

    PubMed  CAS  Google Scholar 

  14. Rotbart H (1995) Enterviral infection of the central nervous system. Clin Infect Dis 20:971–981

    PubMed  CAS  Google Scholar 

  15. Annegers JF, Hauser WA, Beghi E, Nicolosi A, Kurkland LT (1988) The risk of unprovoked seizures after encephalitis and meningitis. Neurology 38(9):1407–1410

    PubMed  CAS  Google Scholar 

  16. Quagliarello VJ, Scheid WM (1997) Treatment of bacterial meningitis. N Engl J Med 336:708–716

    PubMed  CAS  Google Scholar 

  17. Durand ML, Calderwood SB, Weber DJ, Miller SI, Southwick FS, Caviness VS, Swartz MN (1993) Acute bacterial meningitis in adults: a review of 493 episodes. N Engl J Med 328:21–28

    PubMed  CAS  Google Scholar 

  18. Pfister HW, Feiden W, Einhaupl KM (1993) Spectrum of complications during bacterial meningitis in adults: Results of a clinical study. Arch Neurol 50:575–581

    PubMed  CAS  Google Scholar 

  19. Zoons E, Weisfelt M, de Gans J, Spanjaard L, Koelman JH, Reitsma JB, van de Beek D (2008) Seizures in adults with bacterial meningitis. Neurology 70(22 Pt 2):2109–2115. Epub 2008 Feb 27

    PubMed  CAS  Google Scholar 

  20. Sigurdardottir B, Bjornsson OM, Jonsdottir KE, Erlendsdottir H, Gudmundsson S (1997) Acute bacterial meningitis in adults: a 20-year overview. Arch Intern Med 157:425–430

    PubMed  CAS  Google Scholar 

  21. Hussein AS, Shafran SD (2000) Acute bacterial meningitis in adults: a 12-year review. Medicine (Baltimore) 79(6):360–368

    CAS  Google Scholar 

  22. Igarashi M, Gilmartin RC, Gerald B et al (1984) Cerebral arteritis and bacterial meningitis. Arch Neurol 41:531

    PubMed  CAS  Google Scholar 

  23. Dinubile MJ, Boom WH, Southwick FS (1990) Septic cortical thrombophlebitis. J Infect Dis 161(6):1216–1220

    PubMed  CAS  Google Scholar 

  24. Jordan KG (1999) Continuous EEG monitoring in the neuroscience intensive care unit and emergency department. J Clin Neurophysiol 16(1):14–39

    PubMed  CAS  Google Scholar 

  25. Graman P (1987) Mollaret’s meningitis associated with acute Epstein-Barr virus mononucleosis. Arch Neurol 44:1204–1205

    PubMed  CAS  Google Scholar 

  26. DR SJG, Barringer JR (1982) Isolation of herpes simplex virus type I in recurrent (Mollaret) meningitis. Ann Neurol 11:17–21

    Google Scholar 

  27. Barontini F, Ghezzi M, Marconi GP (1981) A case of benign recurrent meningitis of Mollaret. J Neurol 225(3):197–206

    PubMed  CAS  Google Scholar 

  28. Doern GV, Brueggemann AB, Pierce G et al (1996) Antimicrobial resistance among clinical isolates of Stretococcus pneumoniae recovered from outpatients in the United States during the winter months of 1994 to 1995: results of a 30-center national surveillance study. Antimicrob Agents Chemother 40:1208

    PubMed  CAS  Google Scholar 

  29. Ehrenstein BP, Salzberger B, Glück T (2005) New developments in the diagnosis and therapy of acute bacterial meningitis. Med Klin (Munich) 100(6):325–333

    Google Scholar 

  30. Armstrong WS, McGillicuddy JE (2000) Infections of the central nervous system. In: Crockard A, Hoff JT (eds) Neurosurgery: the scientific basis of clinical practice, vol. 2, 3rd edn. Blackwell Science, Oxford, pp 757–783

    Google Scholar 

  31. Chretien F, Belec L, Hilton DA et al (1996) Herpes simplex virus type I encephalitis in acquired immunodeficiency syndrome. Neuropathol Appl Neurobiol 22:394

    PubMed  CAS  Google Scholar 

  32. Hamilton RL, Achim C, Grafe MR et al (1995) Herpes simpex virus brainstem encephalitis in an AIDS patient. Clin Neuropathol 14:45

    PubMed  CAS  Google Scholar 

  33. Feki I, Marrakchi C, Ben Hmida M et al (2005) Epidemic West Nile virus encephalitis in Tunisia. Neuroepidemiology 24:1–7

    PubMed  Google Scholar 

  34. Schmolck H, Maritz E, Kletzin I et al (2005) Neurologic, neuropsychologic, and electroencephalographic findings after European tickborne encephalitis in children. J Child Neurol 20:500–508

    PubMed  Google Scholar 

  35. Vas GA, Cracco JB (1997) Diffuse encephalopathies. In: Daly DD, Pedley TA (eds) Current practice of clinical electroencephalography. Lippincott-Raven, Philadelphia, USA, pp 371–399

    Google Scholar 

  36. Westmoreland BF (1987) The EEG in cerebral inflammatory processes. In: Electroencephalography-basic principles, clinical applications and related fields. In: Niedermeyer E, Lopes da Silva E (eds) Electroencephalography: basic principles, clinical applications, and related fields. Urban & Schworzenberg, Baltimore-Munich, pp 259–273

    Google Scholar 

  37. Wasay M, Diaz-Arrastia R, Suss RA et al (2000) St Louis encephalitis: a review of 11 cases in a 1995 Dallas, Texas epidemic. Arch Neurol 57:114–118

    PubMed  CAS  Google Scholar 

  38. Brenner RP, Schaul N (1990) Periodic EEG patterns: classification, clinical correlation, and pathophysiology. J Clin Neurophysiol 7:249–267

    PubMed  CAS  Google Scholar 

  39. Klein C, Kimiagar I, Pollak L et al (2002) Neurological features of West Nile Virus infection during the 2000 outbreak in a regional hospital in Israel. J Neurol Sci 200:63–66

    PubMed  CAS  Google Scholar 

  40. Gandelman-Marton R, Kimiagar I, Itzhaki A et al (2003) Electroencephalography findings in adult patients with West Nile virus associated meningitis and meningoencephalitis. Clin Infect Dis 37:1573–1578

    PubMed  CAS  Google Scholar 

  41. Bagic A, Boudreau EA, Greenfield J, Sato S (2007) Electro-clinical evolution of refractory non-convulsive status epilepticus caused by West Nile virus encephalitis. Epileptic Disord 9(1):98–103

    PubMed  Google Scholar 

  42. Marks DA, Kim J, Spencer DD, Spencer SS (1992) Characteristics of intractable seizures following meningitis and encephalitis. Neurology 42(8):1513–1518

    PubMed  CAS  Google Scholar 

  43. Advisory Committee on Immunization Practices (1993) Inactivated Japanese encephalitis virus vaccine. Recommendations of the Advisory Committee on Immunization Practises (ACIP). MMWR Morb Mortal Wkly Rep 42(RR-1):1–15

    Google Scholar 

  44. Hoke CH, Nisalak A, Sangawhipa N, Jatanasen S, Laorakapongse T, Innis BL et al (1988) Protection against Japanese encephalitis by inactivated vaccines. New Engl J Med 319:608–614

    PubMed  CAS  Google Scholar 

  45. Solomon T, Dung NM, Kneen R, Gainsborough M, Vaughn DW, Khanh VT (2000) Neurological aspects of tropical disease: Japanese encephalitis. J Neurol Neurosurg Psychiatry 68:405–415

    PubMed  CAS  Google Scholar 

  46. Tsai TF (1997) Factors in the changing epidemiology of Japanese encephalitis and West Nile fever. In: Saluzzo JF, Dodet B (eds) Factors in the emergence of arbovirus diseases. Elseveir, Paris, pp 179–189

    Google Scholar 

  47. Kaiser R (1999) The clinical and epidemiological profile of tick-borne encephalitis in southern Germany 1994–98: a prospective study of 656 patients. Brain 122:2067–2078

    PubMed  Google Scholar 

  48. Solomon T, Cardosa MJ (2000) Emerging arboviral encephalitis. Br Med J 321:1484–1485

    CAS  Google Scholar 

  49. Johnson RT, Burke DS, Elwell M, Leake CJ, Nisalak A, Hoke CH et al (1985) Japanese encephalitis: immunocytochemical studies of viral antigen and inflammatory cells in fatal cases. Ann Neurol 18:567–573

    PubMed  CAS  Google Scholar 

  50. Solomon T, Dung NM, Kneen R, Thao LTT, Gainsborough M, Nisalak A, Day NPJ, Kirkham FJ, Vaughn DW, Smith S, White NJ (2002) Seizures and raised intracranial pressure in Vietnamese patients with Japanese encephalitis. Brain 125:1084–1093

    PubMed  Google Scholar 

  51. Minns RA, Brown JK (1978) Intracranial pressure changes associated with childhood seizures. Dev Med Child Neurol 20:561–569

    PubMed  CAS  Google Scholar 

  52. Shorvon SD (1994) Status epilepticus: its clinical features and treatment in children and adults. Cambridge University Press, Cambridge

    Google Scholar 

  53. Simpson H, Habel AH, George EL (1977) Cerebrospinal fluid acid-base status and lactate and pyruvate concentrations after convulsions of varied duration and aetiology in children. Arch Dis Child 52:844–849

    PubMed  CAS  Google Scholar 

  54. Bertram M, Schwarz S, Hacke W (1997) Acute and critical care in neurology. Eur Neurol 38:155–166

    PubMed  CAS  Google Scholar 

  55. Osborn A (1994) Infections of the brain and its linings. Edition 1 In: Diagnostic neuroradiology. Mosby, St Louis, 673–715

    Google Scholar 

  56. Kennedy PGE (1988) A retrospective analysis of forty-six cases of herpes simplex encephalitis seen in Glasgow between 1962 and 1985. Q J Med 68:533–540

    PubMed  CAS  Google Scholar 

  57. McGrath N, Anderson NE, Croxson MC, Powell KF (1997) Herpes simplex encephalitis treated with acyclovir: diagnosis and long term outcome. J Neurol Neurosurg Psych 63(3):321–326

    CAS  Google Scholar 

  58. Lai CW, Gragasin ME (1988) Electroencephalography in herpes simplex encephalitis. J Clin Neurophysiol 5(1):87–103

    PubMed  CAS  Google Scholar 

  59. Jha S, Patel R, Yadav RK, Kumar V (2004) Clinical spectrum, pitfalls in diagnosis and therapeutic implications in herpes simplex encephalitis. J Assoc Physicians India 52:24–26

    PubMed  CAS  Google Scholar 

  60. Smith JB, Westmoreland BF, Reagan TJ et al (1975) A distinctive clinical EEG profile in herpes simplex encephalitis. Mayo Clin Proc 50:469

    PubMed  CAS  Google Scholar 

  61. Whitley RJ, Gnann JW (2002) Viral encephalitis: familiar infections and emerging pathogens. Lancet 359:507–514

    PubMed  Google Scholar 

  62. Wijdicks E (2000) Acute encephalitis. Neurologic Catastrophes in the Emergency Department. Butterworth Heinemann, Boston, pp 195–214

    Google Scholar 

  63. Hokkanen L, Salonen O, Launes J (1996) Amnesia in acute herpetic and nonherpetic encephalitis. Arch Neurol 53:972

    PubMed  CAS  Google Scholar 

  64. Launes J, Sirén J, Valanne L et al (1997) Unilateral hyperfusion in brain-perfusion SPECT predicts poor prognosis in acute encephalitis. Neurology 48:1347

    PubMed  CAS  Google Scholar 

  65. Preiser W, Weber B, Klos G et al (1996) Unusual course of herpes simplex virus encephalitis after acyclovir therapy. Infection 24:384

    PubMed  CAS  Google Scholar 

  66. Schlitt M, Bucher AP, Stroop WG, Pindak F, Bastian FO, Jennings RA, Lakeman AD, Whitley RJ (1988) Neurovirulence in an experimental focal herpes encephalitis: relationship to observed seizures. Brain Res 440(2):293–298

    PubMed  CAS  Google Scholar 

  67. Jay V, Hwang P, Hoffman HJ, Becker LE, Zielenska M (1998) Intractable seizure disorder associated with chronic herpes infection. HSV1 detection in tissue by the polymerase chain reaction. Child’s Nervous Syst 14(1–2):15–20

    CAS  Google Scholar 

  68. Pruzanski W, Altman R (1962) Encephalitis due to West Nile fever virus. World Neurol 3:524–527

    PubMed  CAS  Google Scholar 

  69. Nash D, Mostashari F, Fine A et al (2001) West Nile Outbreak Response Working Group. The outbreak of West Nile virus infection in the New York City area in 1999. N Engl J Med 344:1807–1814

    PubMed  CAS  Google Scholar 

  70. Chowers MY, Lang R, Nassar F et al (2001) Clinical characteristics of the West Nile fever outbreak, Israel, 2000. Emerg Infect Dis 7:675–678

    PubMed  CAS  Google Scholar 

  71. Berner YN, Lang R, Chowers MY (2002) Outcome of West Nile fever in older adults. J Am Geriatr Soc 50:1844–1846

    PubMed  Google Scholar 

  72. Petersen LR, Marfin AA (2002) West Nile virus: a primer for the clinician. Ann Intern Med 137:173–179

    PubMed  Google Scholar 

  73. Sagher O, Hoff J (1997) Surgical management of CNS infections. In: Scheld WM, Whitley R, Durack DT (eds) Infections of the central nervous system, 2nd ed. Lippincott-Raven, Philadelphia, pp 945–972

    Google Scholar 

  74. DellaBadia J Jr, Jaffe SL, Singh J, Minagar A (2004) An occipital lobe epileptogenic focus in a patient with West Nile encephalitis. Eur J Neurol 11(2):111–113

    PubMed  Google Scholar 

  75. Roos KL, Tunkel AR, Scheld WM (1997) Acute bacterial meningitis in children and adults. In: Scheld WM, Whitley R, Durack DT (eds) Infections of the central nervous system, 2nd ed. Lippincott-Raven Publishers, Philadelphia, pp 335–402

    Google Scholar 

  76. Wijdicks E (2000) Acute bacterial infections of the central nervous system. Neurologic Catastrophes in the Emergency Department. Butterworth Heinemann, Boston, pp 183–194

    Google Scholar 

  77. Calliauw L, de Praetere P, Verbeke L (1984) Postoperative epilepsy in subdural suppurations. Acta Neurochirurgica 71:217–223

    PubMed  CAS  Google Scholar 

  78. Nicolosi A, Hauser WA, Musicco M, Kurland LT (1991) Incidence and prognosis of brain abscess in a defined population: Olmstead County, Minnesota, 1935–1981. Neuroepidemiology 10(3):122–131

    PubMed  CAS  Google Scholar 

  79. Zeidman SM, Geisler FH, Olivi A (1995) Intraventricular rupture of a purulent brain abscess: case report. Neurosurgery 36:189

    PubMed  CAS  Google Scholar 

  80. Zimmerman RA, Girard NJ (1997) Imaging of Intracranial Infections. In: Scheld WM, Whitley RJ, Durack DT (eds) Infections of the central nervous system, 2nd ed. Lippincott-Raven, Philadelphia, pp 923–944

    Google Scholar 

  81. Tsai YD, Chang WN, Shen CC, Lin YC, Lu CH, Liliang PC, Su TM, Ra CS, Lu K, Liang CL (2003) Intracranial suppuration: a clinical comparison of subdural empyemas and epidural abscesses. Surg Neurol 59(3):191–196

    PubMed  Google Scholar 

  82. Smith HP, Hendrick EB (1983) Subdural empyema and epidural abscess in children. J Neurosurg 58(3):392–397

    PubMed  CAS  Google Scholar 

  83. Bok AP, Peter JC (1993) Subdural empyema: burr holes or craniotomy? A retrospective computerized tomography-era analysis of treatment in 90 cases. J Neurosurg 78:574

    PubMed  CAS  Google Scholar 

  84. Mauser HW, Ravijst R, Elderson A et al (1985) Nonsurgical treatment of subdural empyema. Case report. J Neurosurg 63:128

    PubMed  CAS  Google Scholar 

  85. Salmon J (1972) Ventriculitis complicating meningitis. Amer J Dis Child 124:35–40

    PubMed  CAS  Google Scholar 

  86. Barkovich A (1990) Infections of the nervous system. In: Barkovich AJ (ed) Pediatric neuroimaging. Raven Press, New York, pp 293–325

    Google Scholar 

  87. Ines DF, Marlkand ON (1977) Epileptic seizures and abnormal electroencephalographic findings in hydrocephalus and their relation to the shunting procedures. Electroencephalog Clin Neurophysiol 42(6):761–768

    CAS  Google Scholar 

  88. Dan NG, Wade MJ (1986) The incidence of epilepsy after ventricular shunting procedures. J Neurosurg 65(1):19–21

    PubMed  CAS  Google Scholar 

  89. Sato O, Yamaguchi T, Kittaka M, Toyama H (2001) Hydrocephalus and epilepsy. Childs Nervous Syst 17(1–2):76–86

    CAS  Google Scholar 

  90. Piatt JH, Carlson CV (1995) Hydrocephalus and epilepsy: an actuarial analysis. Neurosurgery 39(4):722–728

    Google Scholar 

  91. Bourgeois M, Sainte-Rose C, Cinalli G, Maixner W, Malucci C, Zerah M, Pierre-Kahn A, Renier D, Hoppe-Hirsch E, Aicardi J (1999) Epilepsy in children with shunted hydrocephalus. J Neurosurg 90(2):274–281

    PubMed  CAS  Google Scholar 

  92. Wilhelm M (1991) Vancomycin. Mayo Clin Proc 66:1165–1170

    PubMed  CAS  Google Scholar 

  93. Redfield DC, Underman A, Norman D, Overturf GD (1980) Cerebrospinal fluid penetration of vancomycin in bacterial meningitis. In: Nelson JD, Geraci C (eds) Current chemotherapy and infectious disease. Proceedings of the International Congress of Chemotherapy and the 19th Interscience Conference on Antimicrobial Agents and Chemotherapy, vol 1. American Society for Microbiology, Washington, DC, pp 638–640

    Google Scholar 

  94. Luer MS, Hatton J (1993) Vancomycin administration into the cerebrospinal fluid: A review. Ann Pharmacther 27:912–921

    CAS  Google Scholar 

  95. BA GDJ, Kelly DL, Pegram S (1986) Gram-negative bacillary meningitis in the adult: review of 39 cases. Southern Med J 79:1499–1502

    Google Scholar 

  96. McCracken GH, Mize SG, Threlkeld N (1980) Intraventricular gentamycin therapy in gram-negative bacillary meningitis of infancy. Lancet 1:787–791

    PubMed  Google Scholar 

  97. Holtzman DM, Kaku DA, So YT (1989) NOS associated with HIV infection: causation and clinical features in 100 cases. Am J Med 87:173–177

    PubMed  CAS  Google Scholar 

  98. Lee KC, Garcia PA, Alldredge BK (2005) Clinical features of status epilepticus in patients with HIV infection. Neurology 65(2):314–316

    PubMed  Google Scholar 

  99. Kellinghaus C, Engbring C, Kovac S, Möddel G, Boesebeck F, Fischera M, Anneken K, Klönne K, Reichelt D, Evers S, Husstedt IW (2008) Frequency of seizures and epilepsy in neurological HIV-infected patients. Seizure 17(1):27–33. Epub 2007 Jul 6

    PubMed  CAS  Google Scholar 

  100. Aronow HA, Feraru ER, Lipton RB (1989) New-onset seizures in AIDS patients: etiology, prognosis, and treatment. Neurology 39:428(Suppl)

    Google Scholar 

  101. Wong MC, Suite NDA, Douglas RL (1990) Seizures in human immunodeficiency virus infection. Arch Neurol 47:640–642

    PubMed  CAS  Google Scholar 

  102. Van Paesschen, Pesola GR, Westfal RE (1998) New-onset generalized seizures in patients with AIDS presenting to an emergency department. Acad Emerg Med 5(9):905–911

    Google Scholar 

  103. Pascual-Sedano B, Iranzo A, Marti-Fabregas J et al (1999) Prospective study of new-onset seizures in patients with immunodeficiency virus infection. Arch Neurol 56:609–612

    PubMed  CAS  Google Scholar 

  104. Modi G, Modi M, Martinus J, Saffer D (2000) New onset seizures associated with human immunodeficiency virus infection. Neurology 55(10):1558–1561

    PubMed  CAS  Google Scholar 

  105. Van Paesschen W, Bodian C, Maker H (1995) Metabolic abnormalities and new onset seizures in human immunodeficiency virus – seropositive patients. Epilepsia 36:146–150

    PubMed  Google Scholar 

  106. Garg RK (1999) HIV infection and seizures. Postgrad Med J 75:387–390

    PubMed  CAS  Google Scholar 

  107. Dore GJ, Law MG, Brew BJ (1996) Prospective analysis of seizures occurring in human immunodeficiency virus type-1 infection. J Neuro AIDS 1:59–69

    CAS  Google Scholar 

  108. Moulignier A, Mikol J, Pialoux G, Fenelon G, Gray F, Thiebaut JB (1995) AIDS-associated progressive multifocal leukoencephalopathy revealed by new-onset seizures. Am J Med 99:64–68

    PubMed  CAS  Google Scholar 

  109. Ajmani A, Habte-Gabr E, Zarr M, Jayabalan V, Dandala S (1991) Cerebral blood flow SPECT with Tc-99m exametamine correlates in AIDS dementia complex stages. A preliminary report. Clin Nucl Med 16(19):656–659

    PubMed  CAS  Google Scholar 

  110. Barry M, Gibbons S, Back D, Mulcahy F (1997) Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet 32:194–209

    PubMed  CAS  Google Scholar 

  111. Romanelli F, Ryan M (2002) Seizures in HIV-seropositive individuals: epidemiology and treatment. CNS Drugs 16(2):91–98

    PubMed  CAS  Google Scholar 

  112. Romanelli F, Pomeroy C (2003) Concurrent use of antiretrovirals and anticonvulsants in human immunodeficiency virus (HIV) seropositive patients. Curr Pharm Des 9(18):1433–1439

    PubMed  CAS  Google Scholar 

  113. Hugen PW, Burger DM, Brinkman K, ter Hofstede HJ, Schuurman R, Koopmans PP, Hekster YA (2000) Carbamazepine-indinavir interaction causes antiretroviral therapy failure. Ann Pharmacotherapy 34(4):465–470

    CAS  Google Scholar 

  114. Toler SM, Wilkerson MA, Porter WH, Smith AJ, Chandler MH (1990) Severe phenytoin intoxication as a result of altered protein binding in AIDS. DICP 24(7–8):698–700

    PubMed  CAS  Google Scholar 

  115. Romanelli F, Jennings HR, Nath A, Ryan M, Berger J (2000) Therapeutic dilemma: the use of anticonvulsants in HIV-positive individuals. Neurology 54(7):1404–1407

    PubMed  CAS  Google Scholar 

  116. Moog C, Kuntz-Simon G, Caussin-Schwemling C, Obert G (1996) Sodium valproate, an anticonvulsant drug, stimulates human immunodeficiency virus type 1 replication independently of glutathione levels. J Gen Virol 77(Pt 9):1993–1999

    PubMed  CAS  Google Scholar 

  117. Jennings HR, Romanelli F (2000) Comment: risk of drug-disease and disease-drug interactions with anticonvulsants in HIV-positive patients. Ann Pharmacotherapy 33(12):1373–13749

    Google Scholar 

  118. Maggi JD, Halman MH (2001) The effect of divalproex sodium on viral load: a retrospective review of HIV-positive patients with manic syndromes. Can J Psychiatry 46(4):359–362

    PubMed  CAS  Google Scholar 

  119. Fieschi C, Rasura M, Anzini A, Beccia M (1998) Central nervous system vasculitis. J Neurol Sci 153:159–171

    PubMed  CAS  Google Scholar 

  120. Ferro JM (1998) Vasculitis of the central nervous system. J Neurol 245:766–776

    PubMed  CAS  Google Scholar 

  121. Goerres GW, Revesz T, Duncan J, Banati RB (2001) Imaging cerebral vasculitis in refractory epilepsy using [11 C](R)-PK11195 Positron emission tomography. AJR 176:1016–1018

    PubMed  CAS  Google Scholar 

  122. Coblyn JS, McCluskey RT (2003) Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 3-2003. A 36-year-old man with renal failure, hypertension, and neurologic abnormalities. New England J Med 348(4):333–342

    Google Scholar 

  123. Moore PM, Fauci AS (1981) Neurologic manifestations of systemic vasculitis. Am J Med 71:517–524

    PubMed  CAS  Google Scholar 

  124. Messing RO, Simon RP (1986) Seizures as a manifestation of systemic disease. Neurol Clin 4(3):563–584

    PubMed  CAS  Google Scholar 

  125. Sehgal M, Swanson JW, Deremee RA, Colby TV (1995) Neurologic manifestations of Churg-Strauss syndrome. Mayo Clinic Proc 70(4):337–341

    CAS  Google Scholar 

  126. Feinglass EJ, Arnett FC, Dorsch CA, Zizic TM, Stevens MB (1976) Neuropsychiatric manifestations of systemic lupus erythematosus: diagnosis, clinical spectrum, and relationship to other features of the disease. Medicine (Baltimore) 55:323–339

    CAS  Google Scholar 

  127. Van Dam AP (1991) Diagnosis and pathogenesis of CNS lupus. Rheumatol Int 11(1):1–11

    PubMed  Google Scholar 

  128. Mok CC, Lau CS, Wong RW (2001) Neuropsychiatric manifestations and their clinical associations in southern Chinese patients with systemic lupus erythematosus. J Rheumatol 28(4):766–771

    PubMed  CAS  Google Scholar 

  129. Karassa FB, Ioannidis JPA, Touloumi G, Boki KA, Moutsopoulos HM (2000) Risk factors for central nervous system involvement in systemic lupus erythematosus. Q J Med 93:169–174

    CAS  Google Scholar 

  130. Gibson T, Myers AR (1975) Nervous system involvement in systemic lupus erythematosus. Ann Rheum Dis 35:398–406

    PubMed  CAS  Google Scholar 

  131. Herranz MT, Rivier G, Khamashta MA, Blaser KU, Hughes GR (1994) Association between antiphospholipid antibodies and epilepsy in patients with systemic lupus erythematosus. Arthritis Rheum 37(4):568–571

    PubMed  CAS  Google Scholar 

  132. Shrivastava A, Dwivedi S, Aggarwal A, Misra R (2001) Anti-cardiolipin and anti-beta2 glycoprotein I antibodies in Indian patients with systemic lupus erythematosus: association with the presence of seizures. Lupus 10(1):45–50

    Google Scholar 

  133. Liou HH, Wang CR, Chou HC, Arvanov VL, Chen RC, Chang YC, Chuang CY, Chen CY, Tsai MC (1994) Anticardiolipin antisera from lupus patients with seizures reduce a GABA receptor-mediated chloride current in snail neurons. Life Sci 54(15):1119–1125

    PubMed  CAS  Google Scholar 

  134. Ellis SG, Verity MA (1979) Central nervous system involvement in systemic lupus erythematosis: a review of neuropathologic findings in 57 cases, 1955–1977. Semin Arthritis Rheum 8:212–221

    PubMed  CAS  Google Scholar 

  135. West SG (1994) Neuropsychiatric lupus. Rheum Dis Clin North Am 20:129–158

    PubMed  CAS  Google Scholar 

  136. Simantov R, Lo SK, Gharavi A, Sammaritano LR, Salmon JE, Silverstein RL (1996) Antiphospholipid antibodies activate vascular endothelial cells. Lupus 5:440–441

    PubMed  CAS  Google Scholar 

  137. Pierangeli SS, Colden-Stanfield M, Liu X, Barker JH, Anderson Gl, Harris EN (1999) Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. Circulation 99:1997–2002

    PubMed  CAS  Google Scholar 

  138. Seibold JR, Buckingham RB, Medsger TA et al (1982) Cerebrospinal fluid immune complexes in systemic lupus erythematosis involving the central nervous system. Semin Arthritis Rheum 12:68–76

    PubMed  CAS  Google Scholar 

  139. Atkins CJ, Kondon JJ, Quismorio FP et al (1972) The choroid plexus in systemic lupus erythematosis. Ann Intern Med 76:65–72

    PubMed  CAS  Google Scholar 

  140. Winfield JB, Shaw M, Silverman LM et al (1983) Intrathecal IgG synthesis and blood brain barrier impairment in patients with systemic lupus erythematosus and central nervous system dysfunction. Am J Med 74:837–844

    PubMed  CAS  Google Scholar 

  141. Bluestein HG, Zvaifler NJ (1976) Brain-reactive lymphocytotoxic antibodies in the serum of patients with systemic lupus erythematosus. J Clin Invest 57:509–516

    PubMed  CAS  Google Scholar 

  142. Levite M, Ganor Y (2008) Autoantibodies to glutamate receptors can damage the brain in epilepsy, systemic lupus erythematosus and encephalitis. Expert Rev Neurother 8(7):1141–1160

    PubMed  CAS  Google Scholar 

  143. Cohen SB, Hurd ER (1981) Neurological complications of connective tissue and other “collagen-vascular” diseases. Semin Arthritis Rheum 11:190–212

    PubMed  CAS  Google Scholar 

  144. Hanly JG, Walsh NM, Sangalang V (1992) Brain pathology in systemic lupus erythematosus. J Rheumatol 19(5):732–741

    PubMed  CAS  Google Scholar 

  145. Primavera A, Audenino D, Mavilio N, Cocito L (2001) Reversible posterior leucoencephalopathy syndrome in systemic lupus and vasculitis. Ann Rheum Dis 60:534–537

    PubMed  CAS  Google Scholar 

  146. Bessmertny O, Pham T (2002) Antiepileptic hypersensitivity syndrome: clinicians beware and be aware. Curr Allergy Asthma Rep 2(1):34–39

    PubMed  Google Scholar 

  147. Vittorio CC, Muglia JJ (1995) Anticonvulsant hypersensitivity syndrome. Arch Int Med 155(21):2285–2290

    CAS  Google Scholar 

  148. Drory VE, Korczyn AD (1993) Hypersensitivity vasculitis and systemic lupus erythematosus induced by anticonvulsants. Clin Neuropharmacol 16(1):19–29

    PubMed  CAS  Google Scholar 

  149. Beck DO, Corbett JJ (1983) Seizures due to central nervous system rheumatoid meningo-vasculitis. Neurology 33:1058–1061

    PubMed  CAS  Google Scholar 

  150. Jan JE, Hill RH, Low MD (1972) Cerebral complications in juvenile rheumatoid arthritis. Can Med Assoc J 107:623–625

    PubMed  CAS  Google Scholar 

  151. Makela A, Heikki L, Sillanpaa M (1979) Neurological manifestations of rheumatoid arthritis. In: Vinken PJ, Bruyen GW (eds) Handbook of clinical neurology, vol 38. Elsevier North Holland, Amsterdam, pp 479–503

    Google Scholar 

  152. Mandybur TI (1979) Cerebral amyloid angiopathy: possible relationship to rheumatoid vasculitis. Neurology 29:1336–1340

    PubMed  CAS  Google Scholar 

  153. Neamtu L, Belmont M, Miller DC, Leroux P, Weinberg H, Zagzag D (2001) Rheumatoid disease of the CNS with meningeal vasculitis presenting with a seizure. Neurology 56:814–815

    PubMed  CAS  Google Scholar 

  154. Hietaharju A, Jaaskelainen S, Hietarinta M, Frey H (1993) Central nervous system involvement and psychiatric manifestations in systemic sclerosis (scleroderma): clinical and neurophysiological evaluation. Acta Neurol Scand 87:382–387

    PubMed  CAS  Google Scholar 

  155. Estey E, Lieberman A, Pinto R et al (1979) Cerebral arteritis in scleroderma. Stroke 10:595–597

    PubMed  CAS  Google Scholar 

  156. Alexander E (1992) Central nervous system disease in Sjogren’s syndrome. Rheum Dis Clin North Am 18:637–672

    PubMed  CAS  Google Scholar 

  157. Spezialetti R, Bluestein HG, Peter JB, Alexander EL (1993) Neuropsychiatric disease in Sjogren’s syndrome: anti-ribosomal P and anti-neuronal antibodies. Am J Med 95:153–160

    PubMed  CAS  Google Scholar 

  158. Bennett RM, Bong DM, Spargo BH (1978) Neuropsychiatric problems in mixed connective tissue disease. Am J Med 65:955–962

    PubMed  CAS  Google Scholar 

  159. Akhan G, Andermann F, Gotman MJ (2002) Ulcerative colitis, status epilepticus and intractable temporal seizures. Epileptic Disord 4(2):135–137

    PubMed  Google Scholar 

  160. Akman-Demir G, Serdaroglu P, Tasci B et al (1999) Clinical patterns of neurological involvement in Behçet disease: evaluation of 200 patients. Brain 122:2171–2182

    PubMed  Google Scholar 

  161. International Study Group for Behçet’s Disease (1990) Criteria for diagnosis of Behçet’s disease. Lancet 335:1078–1080

    Google Scholar 

  162. Kidd D, Steuer A, Denman AM et al (1999) Neurological complications in Behçet’s syndrome. Brain 122:2183–2194

    PubMed  Google Scholar 

  163. Aykutlu E, Baykan B, Serdaroglu P, Gokyigit A, Akman-Demir G (2002) Epileptic seizures in Behçet Disease. Epilepsia 43(8):832–835

    PubMed  Google Scholar 

  164. Duran E, Chacon JR (2001) Behçet’s disease with atypical double neurological involvement. Rev Neurol 33(4):333–334

    PubMed  CAS  Google Scholar 

  165. El Bahri Ben Mvad et al (2002) Central venous thrombosis and Bechet’s disease. Tunis Med 80(2):87–89

    Google Scholar 

  166. O’Duffy JD, Calamia K, Cohen S, Goronzy JJ, Herman D, Jorizzo J, Weyand C, Matteson E (1998) Interferon-alpha treatment of Behçet’s disease. J Rheumatol 25(10):1938–1944

    PubMed  Google Scholar 

  167. Vignola S, Nobili F, Picco P, Gattorno M, Buoncompagni A, Vitali P, Mariani G, Rodriguez G (2001) Brain perfusion spect in juvenile neuro-Behçet’s disease. J Nucl Med 42(8):1151–1157

    PubMed  CAS  Google Scholar 

  168. Mead S, Kidd D, Good C, Plant G (2000) Behçet’s syndrome may present with seizures. J Neurol Neurosurg Psych 68(3):392–393

    CAS  Google Scholar 

  169. Valeyre D, Chapelon-Abric C, Belin C, Dumas JL (1998) Sarcoidosis of the central nervous system. Rev Med Interne 19(6):409–414

    PubMed  CAS  Google Scholar 

  170. Joseph FG, Scolding NJ (2007) Sarcoidosis of the nervous system. Pract Neurol 7(4):234–244

    PubMed  CAS  Google Scholar 

  171. Varelas PN (2008) How I treat status epilepticus in the Neuro-ICU. Neurocrit Care 9(1):153–157

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Anesthesia and Neurosurgery, Neurosciences Critical Care Division, Departments of Neurology, Neurosurgery, and Anesthesiology, Critical Care Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA

    Wendy C. Ziai (Assistant Professor of Neurology)

  2. Neurocritical Care, Henry Ford Hospital, Detroit, MI, USA

    Mohammed Rehman (Fellow)

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  1. Wendy C. Ziai
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  2. Mohammed Rehman
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Correspondence to Wendy C. Ziai .

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  1. Dept. Neurology, Henry Ford Hospital, W. Grand Blvd. 2799 , Detroit, 48202-2689, U.S.A.

    Panayiotis Varelas

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Ziai, W.C., Rehman, M. (2010). Infection or Inflammation and ICU Seizures. In: Varelas, P. (eds) Seizures in Critical Care. Current Clinical Neurology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-532-3_10

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