Hepatocellular Cancer: Pathologic Considerations

  • Gregory Y. Lauwers


While the incidence of HCCs has been rising worldwide, there has been a steady stream of novel information related to the histologic characteristics of HCCs, including their pattern of spread, the risk factors for recurrence, and long-term prognosis. More particularly, a focus of great interest has been the diagnosis of early HCC. Understanding by histopathologists, surgeons, hepatologists, and oncologists of the nuances of the diagnosis of early HCC, as well as the importance of detailed pathologic analysis of surgical specimens, is crucial to developing appropriate therapeutic algorithms based on precise prognostic stratification.


Histology Prognostic factors Precursor lesions 


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Gregory Y. Lauwers
    • 1
  1. 1.Department of PathologyMassachusetts General HospitalBostonUSA

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