Abstract
In humans, plasma iron concentrations are normally maintained in a relatively narrow range of 10–30 μM with transferrin saturation 20–40%. Prolonged decrease of iron concentrations causes cellular dysfunction and anemia (Chap. 15). Severe and prolonged increase of iron concentrations results in iron deposition in vital organs with consequent tissue injury (Chap. 18). With an average plasma volume of 3 l and iron concentration of 1 mg/l, plasma contains only about 3 mg of iron, a small fraction of the total body iron content of 3–4 g. Assuming free equilibration of iron–transferrin into 15 l of extracellular fluid, extracellular iron amounts to only 15 mg.
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Ganz, T., Vaulont, S. (2012). Molecular Regulation of Systemic Iron Metabolism. In: Anderson, G., McLaren, G. (eds) Iron Physiology and Pathophysiology in Humans. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-60327-485-2_9
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