Clinical Correlation

Disorders of Neuronal Migration
  • Gregory Cooper
  • Gerald Eichhorn
  • Robert Rodnitzky

Abnormalities in the process of neuronal migration during embryogenesis result in CNS structures that are dysfunctional, architecturally abnormal, or totally absent. Several distinct mechanisms can be operative in the pathogenesis of clinical disorders related to disrupted neuronal migration. Some neuronal migrational disorders are heritable, and others are presumed to be the result of ischemic, toxic, or metabolic damage during the perinatal period.

Cortical Neurons in Neuronal Migration Disorders

The most common neuronal migration abnormalities involve the neocortex. In humans, normal neuronal migration to the cerebral cortex takes place mostly during the 8th to the 24th week of gestation. Neurons originating deep in the brain along the surface of the ventricles migrate to the cortex along a network of extensions of glial cells known as radial glia. The first neurons to arrive populate the deepest layer of the cortex, and successive groups of arriving cells occupy progressively more...


Olfactory Bulb Neural Cell Adhesion Molecule Neuronal Migration Radial Glia Olfactory Placode 
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Selected Readings

  1. Barkovich AJ, Kuzniecky RI, Jackson GD, Guerrini R, Dobyns WB. A developmental and genetic classification for malformations of cortical development. Neurology. 2005;65(12):1873–87.PubMedCrossRefGoogle Scholar
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  3. Francis F, Meyer G, Fallet-Bianco C, Moreno S, Kappeler C, Socorro AC, Tuy FP, Beldjord C, Chelly J. Human disorders of cortical development: from past to present. Eur J Neurosci. 2006;23(4):877–93.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press, Totowa, NJ 2008

Authors and Affiliations

  • Gregory Cooper
    • 1
  • Gerald Eichhorn
    • 2
  • Robert Rodnitzky
    • 3
  1. 1.Sanders-Brown Center on Aging, The University of Kentucky, Lexington, KY, USAThe Lexington ClinicLexingtonUSA
  2. 2.The Lexington ClinicLexingtonUSA
  3. 3.Department Head of NeurologyUniversity of Iowa Hospitals and ClinicsIowa CityUSA

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