Degeneration, Regeneration, and Plasticity in the Nervous System

  • Paul J. Reier
  • Michael A. Lane


Neurotrauma and neurodegenerative disease often result in catastrophic disruption of the elaborate cellular interactions underlying the functional organization of the nervous system. As a result, devastating disabilities are endured that have been viewed for many years as being irreversible. The first clinical report of traumatic brain and spinal cord injuries was found in an Egyptian papyrus (the Edwin Smith Papyrus) dating back more than 3500 years, which described both conditions as “an ailment not to be treated.” Recent basic science discoveries, however, have begun to temper centuries of pessimism. A challenge of current basic and clinical research is to define novel therapeutic approaches to promote functional repair and significant improvement in quality of life. Contemporary medical neuroscience education thus warrants an appreciation for scientific advances in neurologic research and how preclinical progress may ultimately translate into future clinical...


Schwann Cell Growth Cone Axonal Regeneration Peripheral Nerve Injury Central Nervous System Injury 
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Copyright information

© Humana Press, Totowa, NJ 2008

Authors and Affiliations

  • Paul J. Reier
    • 1
  • Michael A. Lane
    • 2
  1. 1.Department of NeuroscienceUniversity of Florida College of Medicine and McKnight Brain InstituteGainesvilleUSA
  2. 2.Department of NeuroscienceUniversity of Florida College of Medicine and McKnight Brain InstituteGainesvilleUSA

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