Neuroimmunology: An Overview

  • Michael D. Lumpkin


The term neuroimmunology means different things to different biomedical scientists and clinicians. This evolving and broad discipline includes the study of secreted immune cell products known as cytokines, lymphokines, monokines, and chemokines and their presence and actions in the central and peripheral nervous systems. Another area of study is that in which the nerve supply and nervous system regulation of lymphoid organs such as the spleen and thymus gland are considered. A third connotation of this word involves the investigation of how neuroendocrine substances of the hypothalamic-pituitary unit regulate the proliferation and activities of monocytes, macrophages, lymphocytes, and glial cells(considered by some to be the “macrophages of the brain”). A fourth implication of neuroimmunology is recognition of the fact that immune cells can produce neuroendocrine peptides such as adrenocorticotropic hormone (ACTH) and luteinizing hormone releasing hormone (LHRH). A fifth...


Thyroid Stimulate Hormone Vasoactive Intestinal Peptide Corticotropin Release Factor Thymus Gland Acquire Immune Deficiency Syndrome Patient 
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Selected Readings

  1. Advances in Neuroimmunology. Annals of the New York Academy of Sciences. C.S. Raine, ed., Vol. 540, 1988.Google Scholar
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  5. Lumpkin, M.D. Clinical approaches to hormonal and neuroendocrine imbalances. The hypothalamus-pituitary-adrenal axis. In: Textbook of Functional Medicine, D.S. Jones, S. Quinn, eds., The Institute for Functional Medicine, Gig Harbor, WA, 2005, pp. 610–618.Google Scholar
  6. Mulroney, S.E., McDonnell, K.J., Pert, C.B., Ruff, M.R., Resch, Z., Samson, W.K., Lumpkin, M.D. HIV gp 120 inhibits the somatotropic axis: a possible GH-releasing hormone receptor mechanism for the pathogenesis of AIDS wasting. Proceedings of the National Academy of Sciences USA 95: 1927–1932, 1998.CrossRefGoogle Scholar
  7. Peisen, J.N., McDonnell, K.J., Mulroney, S.E., Lumpkin, M.D. Endotoxin-induced suppression of the somatotropic axis is mediated by interleukin-1 beta and corticotropin releasing factor in the juvenile rat. Endocrinology 136: 3378–3390, 1995.PubMedCrossRefGoogle Scholar
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Copyright information

© Humana Press, Totowa, NJ 2008

Authors and Affiliations

  • Michael D. Lumpkin
    • 1
  1. 1.Department of Physiology and BiophysicsGeorgetown University Medical SchoolWashingtonUSA

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