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Pain is a Complex Sensory Event

Pain can be a useful warning signal, an alarm that prevents us from damaging our bodies irreparably as we go about daily life. On the other hand, pain arising late in the course of disease or produced by dysfunction of the nervous system has no survival value. Indeed, there is accumulating evidence that pain per se can have adverse health effects. For example, pain has been demonstrated in animal studies to inhibit immune function and to enhance tumor growth. In humans, appropriate pain management can be shown to enhance healing. Pain is thus an important clinical issue in its own right.

Although pain is part of everyday life, a clinically and scientifically useful definition of pain is not straightforward. This becomes particularly important when considering some of the types of pain with significant clinical impact. The International Association for the Study of Pain (IASP) therefore developed a consensus definition of pain that is now widely accepted....

Keywords

Neuropathic Pain Dorsal Horn Complex Regional Pain Syndrome Pain Sensation Dorsal Horn Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Selected Readings

  1. Apkarian, A.V., Bushnell, M.C., Treede, R.D. and Zubieta, J.K. Human brain mechanisms of pain perception and regulation in health and disease. Eur. J. Pain, 9: 463–484, 2005.PubMedCrossRefGoogle Scholar
  2. Campbell, J.N. and Meyer, R.A. Mechanisms of neuropathic pain. Neuron, 52: 77–92, 2006.PubMedCrossRefGoogle Scholar
  3. Casey, K.L. Forebrain mechanisms of nociception and pain: analysis through imaging. Proc. Natl. Acad. Sci. U. S. A. 96: 7668–7674, 1999.PubMedCrossRefGoogle Scholar
  4. Cervero, F. Sensory innervation of the viscera: peripheral basis of visceral pain. Physiol. Rev., 74: 95–138, 1994.PubMedCrossRefGoogle Scholar
  5. Fields, H.L. Pain. New York, McGraw-Hill, 1987.Google Scholar
  6. Fields, H.L. and Heinricher, M.M. Anatomy and physiology of a nociceptive modulatory system. Philos. Trans. Roy. Soc. Lond. B, 308: 361–374, 1985.CrossRefGoogle Scholar
  7. Heinricher, M.M. and Ingram, S.L. The brainstem and nociceptive modulation. In: The senses, a comprehensive reference, Vol. 5, Pain; Bushnell, M.C. and Basbaum, A.I. (eds.). Academic Press: San Diego, 593–626, 2008.Google Scholar
  8. McMahon, S. and Koltzenburg, M. (eds.). Wall and Melzack's Textbook of Pain, 5th ed.. London: Elsevier, 2005.Google Scholar

Copyright information

© Humana Press, Totowa, NJ 2008

Authors and Affiliations

  • Mary M. Heinricher
    • 1
  1. 1.Department of Neurological SurgeryOregon Health & Science UniversityPortlandUSA

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