Clinical Correlation

Disorders of the Limbic System
  • Lawrence Ver Hoef
  • Inga Kadish
  • Gregory Cooper
  • Thomas van Groen

The Limbic System Plays a Role in Epilepsy

Many areas of the limbic system play a role in epilepsy, and one of the main areas is the hippocampus. The hypothesized relation between hippocampal formation damage and epileptic seizures dates to the early 19th century, and by 1880 Sommer had clearly identified an area of the hippocampus proper (i.e., Sommer's sectoror area CA1) that was consistently damaged in the epileptic patients that he studied. So-called hippocampal sclerosis typically demonstrates a pattern of preferential neuronal loss and astrogliosis in the CA1 and CA4 (also known as end-folium area) subfields more than in the CA3 subfield and granule cell layer and little to no neuronal loss in the CA2 subfield. Several subsequent reports have supported the idea that, in patients with temporal lobe epilepsy, the epileptogenic focus is in the hippocampus proper in the majority of patients and that limited resection of the hippocampal focus can often abolish subsequent seizure...


Amyloid Precursor Protein Temporal Lobe Epilepsy Entorhinal Cortex Thiamine Deficiency Hippocampal Sclerosis 
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Copyright information

© Humana Press, Totowa, NJ 2008

Authors and Affiliations

  • Lawrence Ver Hoef
    • 1
  • Inga Kadish
    • 2
  • Gregory Cooper
    • 3
  • Thomas van Groen
    • 4
  1. 1.Department of Cell BiologyThe University of Alabama at BirminghamBirminghamUSA
  2. 2.Department of Cell BiologyThe University of Alabama at BirminghamBirminghamUSA
  3. 3.Sanders-Brown Center on AgingThe University of Kentucky, The Lexington ClinicLexingtonUSA
  4. 4.Department of Cell BiologyThe University of Alabama at BirminghamBirminghamUSA

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