Choroid Plexus–Cerebrospinal Fluid Circulatory Dynamics: Impact on Brain Growth, Metabolism, and Repair

  • Conrad E. Johanson

Structural and Functional Components of the Cerebrospinal Fluid

Cerebrospinal fluid (CSF) has a major impact on the fluid environment of neurons. Choroid plexus (CP) tissue in the four ventricles generates 70% to 80% of actively secreted CSF that derives from the carotid and vertebral systems. Upon flowing from choroidal origins to distal sites, CSF contacts other membranes that encompass the hemispheres: the ependyma of the ventricles and the pia/arachnoid of the subarachnoid space (SAS). Consequently, the composition of flowing CSF and adjacent brain interstitium is progressively modified by bidirectional exchanges of water, ions, and proteins (1, 2).

The CSF, then, is a dynamic system working in parallel with cerebral capillary transporters to optimize the neuronal environment. Disrupted transport at the blood-CSF interface (choroid plexuses mainly) and blood-brain barrier (BBB) compromises cerebral function. Although long known that stable brain fluid volume and composition vitally...


Choroid Plexus Fourth Ventricle Bulk Flow Normal Pressure Hydrocephalus Arachnoid Villus 
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Copyright information

© Humana Press, Totowa, NJ 2008

Authors and Affiliations

  • Conrad E. Johanson
    • 1
  1. 1.Program in Neurosurgery, Department of Clinical Neurosciences, Warren Alpert Medical SchoolBrown UniversityProvidenceUSA

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