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Guidelines and Classifications

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Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome

Part of the book series: Current Clinical Practice ((CCP))

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Abstract

This autoimmune disease is the result of genetic environmental triggers. These patients demonstrate CD8 cell infiltration of the islet cells that are likely involved with subsequent beta cell destruction. A long prodrome is usually present from genetic pre-disposition to onset of disease. These patients may demonstrate various antibodies to islet antigens including insulin, glutamic acid decarboxylase (GAD), and tyrosine phosphatase 1A-2. Hence, a combination of markers rather than a single test should be used for predictive and diagnostic testing to enhance sensitivity without losing specificity.

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Authors and Affiliations

  1. University of Pennsylvania Health System Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA

    Ronald A. Codario MD, FACP (Clinical Instructor in Medicine)

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  1. Ronald A. Codario MD, FACP
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Diplomate American Board of Internal Medicine

Diplomate American Board of Clinical Lipidology

Diplomate American Board of Vascular Medicine

Clinical Hypertension Specialist (American Society of Hypertension Certified)

Vascular Ultrasound (American Registry of Diagnostic Sonography Certified)

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Codario, R.A. (2011). Guidelines and Classifications. In: Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome. Current Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-441-8_2

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  • DOI: https://doi.org/10.1007/978-1-60327-441-8_2

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60327-440-1

  • Online ISBN: 978-1-60327-441-8

  • eBook Packages: MedicineMedicine (R0)

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