The Pathophysiology and Metabolic Impact of Hyperglycemia

  • Ronald A. Codario
Part of the Current Clinical Practice book series (CCP)


Accelerated vascular injury and inflammation are intimately associated with the devastating complications of type-2 diabetes. This process is initiated and perpetuated by the pathophysiological consequences of the hyperglycemic state. The vascular devastation of hyperglycemia can occur by several mechanisms, impacting the vessel wall, monocyte derived macrophages, and vascular smooth muscle cells.s

Key Words

Hyperglycemia Vascular injury Inflammation Hyperglycemia Monocyte derived macrophages Vascular smooth muscle cells 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Ronald A. Codario
    • 1
  1. 1.University of Pennsylvania Health System Thomas Jefferson University HospitalPhiladelphiaUSA

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