Skip to main content

Preventive Treatment Options for the Pregnant Headache Patient

  • Chapter
  • First Online:
Effective Migraine Treatment in Pregnant and Lactating Women: A Practical Guide

Key Chapter Points

  • Most pregnant women with headaches note significant improvement in their headache pattern by the end of the first trimester with sustained improvement in the second and third trimesters.

  • Patients failing to note improvement by the end of the first trimester generally continue to experience headaches throughout the remainder of pregnancy. These patients may be candidates for preventive therapy.

  • Use of safe preventive agents is preferred over allowing the woman to overuse acute pain medications and risk developing medication overuse (analgesic rebound) headaches.

  • Non-drug approaches should be considered first and maximized to limit the need for headache preventive medication during pregnancy.

  • Safe options for headache preventive therapy, including propranolol, gabapentin in early pregnancy, and magnesium are available.

  • Headache prevention medication, if used during pregnancy, requires close cooperation among the headache-treating provider, the patient, and the obstetrician.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Marcus DA, Scharff L, Turk DC. Longitudinal prospective study of headache during pregnancy and postpartum. Headache 1999;39:625–632.

    Article  PubMed  CAS  Google Scholar 

  2. Marcus DA, Scharff L, Turk DC. Nonpharmacologial management of headaches during pregnancy. Psychosom Med 1995;57:527–535.

    PubMed  CAS  Google Scholar 

  3. Scharff L, Marcus DA, Turk DC. Maintenance of effects in the nonmedical treatment of headaches during pregnancy. Headache 1996;36:285–290.

    Article  PubMed  CAS  Google Scholar 

  4. Charlton RA, Cunnington MC, de Vries CS, Weil JG. Data resources for investigating drug exposure during pregnancy and associated outcomes. The General Practice Research Database (GPRD) as an alternative to pregnancy registries. Drug Saf 2008;31:39–51.

    Article  PubMed  Google Scholar 

  5. Glover DD, Amonkar M, Rybeck BF, Tracy TS. Prescription, over-the-counter, and herbal medicine use in a rural, obstetric population. Am J Obstet Gynecol 2003;188: 1039–1045.

    Article  PubMed  Google Scholar 

  6. Krymchantowski AV, Moreira PF. Out-patient detoxification in chronic migraine: comparison of strategies. Cephalalgia 2003;23:982–993.

    Article  PubMed  CAS  Google Scholar 

  7. Rossi P, Di Lorenzo C, Faroni J, Cesarion F, Nappi G. Advice alone vs. structured detoxification programmes for medication overuse headaches: a prospective, randomized, open-label trial in transformed migraine patients with low medical needs. Cephalalgia 2006;26:1097–1105.

    Article  PubMed  CAS  Google Scholar 

  8. Benseñor IM, Cook NR, Lee IM, et al. Low-dose aspirin for migraine prophylaxis in women. Cephalalgia 2001;21:175–183.

    Article  PubMed  Google Scholar 

  9. Bayliss H, Churchill D, Beevers M, Beevers DG. Anti-hypertensive drugs in pregnancy and fetal growth: evidence for “pharmacological programming” in the first trimester? Hypertens Pregnancy 2002;21:161–174.

    Article  PubMed  CAS  Google Scholar 

  10. Sørensen HT, Czeizel AE, Rockerbauer M, Steffensen FH, Olsen J. The risk of limb deficiencies and other congenital malformations in children exposed in utero to calcium channel blockers. Acta Obstet Gynecol Scand 2001;80:397–401.

    PubMed  Google Scholar 

  11. Drug Safety Site.com: http://drugsafetysite.com/lisinopril (accessed June 2008).

  12. Mathew NT, Rapoport A, Saper J, et al. Efficacy of gabapentin in migraine prophylaxis. Headache 2001;41:119–128.

    Article  PubMed  CAS  Google Scholar 

  13. Montouris G. Gabapentin exposure in human pregnancy: results from the Gabapentin Pregnancy Registry. Epilepsy Behav 2003;4:310–317.

    Article  PubMed  Google Scholar 

  14. Topiramate (TOPAMAX) prescribing information. In: Physicians’ Desk Reference 2007. Montvale, NJ: Thomson Healthcare;2007;2408.

    Google Scholar 

  15. Vila Cerén C, Demestre Guasch X, Raspall Torrent F, et al. Topiramate and pregnancy. Neonate with bone anomalies. An Pediatr (Barc) 2005;63:363–365.

    Article  Google Scholar 

  16. Hunt S, Russell A, Smithson WH, et al. Topiramate in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register. Neurology 2008; 71:272–276.

    Article  PubMed  CAS  Google Scholar 

  17. Holmes LB, Wyszynski DF, Lieberman E. The AED (Antiepileptic Drug) pregnancy registry. Arch Neurol 2004;61:673–678.

    Article  PubMed  Google Scholar 

  18. Holmes LB, Smith CR, Hernandez-Diaz S. Pregnancy registries: larger sample sizes essential. Birth Defects Research (Part A) 2008;82:307.

    Google Scholar 

  19. Holmes LB, Baldwin EJ, Smith CR, Habecker E, Glassman L, Wong SL, Wyszynski DF. Increased frequency of isolated cleft palate in infants exposed to lamotrigine during pregnancy. Neurology 2008;70:2152–2158.

    Article  PubMed  CAS  Google Scholar 

  20. Hemels ME, Einarson A, Koren G, Lanctot KL, Einarson TR. Antidepressant use during pregnancy and the rates of spontaneous abortions: a meta-analysis. Ann Pharmacother 2005;39:803–809.

    Article  PubMed  Google Scholar 

  21. Oberlander TF, Warburton W, Misri A, Aghajanian J, Hertzman C. Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health data. Arch Gen Psychiatry 2006;63:898–906.

    Article  PubMed  Google Scholar 

  22. Bérard A, Ramos E, Rey E, et al. First trimester exposure to paroxetine and risk of cardiac malformations in infants: the importance of dosage. Birth Defects Res B Dev Reprod Toxicol 2007;80:18–27.

    Article  PubMed  Google Scholar 

  23. Davis RL, Rubanowice D, McPhillips H, et al. Risks of congenital malformations and perinatal events among infants exposed to antidepressant medications during pregnancy. Pharmacoepidemiol Drug Saf 2007;16:1086–1094.

    Article  PubMed  Google Scholar 

  24. Moses-Kolko EL, Bogen D, Perel J, et al. Neonatal signs after late in utero exposure to serotonin reuptake inhibitors: literature review and implications for clinical applications. JAMA 2005;293:2372–2383.

    Article  PubMed  CAS  Google Scholar 

  25. Goodman JF: Treatment of headache with bupropion. Headache 1997;37:256.

    Article  PubMed  CAS  Google Scholar 

  26. Pinsker W: Potentially safe and effective new treatment for migraine? Headache 1998;38:58.

    PubMed  CAS  Google Scholar 

  27. No authors. Bupropion (amfebutamone): caution during pregnancy. Prescrire Int 2005;14:225.

    Google Scholar 

  28. Chun-Fai-Chan B, Koren G, Fayez I, et al. Pregnancy outcome of women exposed to bupropion during pregnancy: a prospective comparative study. Am J Obstet Gynecol 2005;192:932–936.

    Article  PubMed  CAS  Google Scholar 

  29. Cole JA, Modell JG, Haight BR, et al. Bupropion in pregnancy and the prevalence of congenital malformations. Pharmacoepidemiol Drug Saf 2007;16:474–484.

    Article  PubMed  CAS  Google Scholar 

  30. Ashkenazi A, Levin M. Greater occipital nerve block for migraine and other headaches: is it useful? Curr Pain Headache Rep 2007;11:231–235.

    Article  PubMed  Google Scholar 

  31. Ashkenazi AA, Matro R, Shaw JW, Abbas MA, Silberstein SD. Greater occipital nerve block using local anesthestics alone or with triamcinolone for transformed migraine: a randomized comparative study. J Neurol Neurosurg Psychiatry 2008;79:415–417.

    Article  PubMed  CAS  Google Scholar 

  32. Loukas M, El-Sedfy A, Tubbs RS, et al. Identification of greater occipital nerve landmarks for the treatment of occipital neuralgia. Folia Morph 2006;65:337–342.

    CAS  Google Scholar 

  33. Afridi SK, Shields KG, Bhola R, Goadsby PJ. Greater occipital nerve injection in primary headache symptoms—prolonged effects from a single injection. Pain 2006;122:126–129.

    Article  PubMed  CAS  Google Scholar 

  34. Schürks M, Diener H, Goadsby P. Update on the prophylaxis of migraine. Curr Treat Opt Neurol 2008;10:20–29.

    Article  Google Scholar 

  35. De Oliveira Monteiro E. Botulinum toxin and pregnancy. Skinmed 2006;5:308.

    Article  PubMed  Google Scholar 

  36. Evers S, Áfra J, Frese A, et al. EFNS guideline on the drug treatment of migraine—report of an EFNS task force. Eur J Neurol 2006;13:560–572.

    Article  PubMed  CAS  Google Scholar 

  37. Chuang C, Doyle P, Wang J, et al. Herbal medicines used during the first trimester and major congenital malformations. An analysis of data from a pregnancy cohort study. Drug Saf 2006;29:537–548.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Humana Press, a part of Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Marcus, D.A., Bain, P.A. (2009). Preventive Treatment Options for the Pregnant Headache Patient. In: Effective Migraine Treatment in Pregnant and Lactating Women: A Practical Guide. Humana Press. https://doi.org/10.1007/978-1-60327-439-5_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-60327-439-5_6

  • Published:

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-438-8

  • Online ISBN: 978-1-60327-439-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics