Key Chapter Points
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Most pregnant women with headaches note significant improvement in their headache pattern by the end of the first trimester with sustained improvement in the second and third trimesters.
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Patients failing to note improvement by the end of the first trimester generally continue to experience headaches throughout the remainder of pregnancy. These patients may be candidates for preventive therapy.
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Use of safe preventive agents is preferred over allowing the woman to overuse acute pain medications and risk developing medication overuse (analgesic rebound) headaches.
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Non-drug approaches should be considered first and maximized to limit the need for headache preventive medication during pregnancy.
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Safe options for headache preventive therapy, including propranolol, gabapentin in early pregnancy, and magnesium are available.
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Headache prevention medication, if used during pregnancy, requires close cooperation among the headache-treating provider, the patient, and the obstetrician.
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Marcus, D.A., Bain, P.A. (2009). Preventive Treatment Options for the Pregnant Headache Patient. In: Effective Migraine Treatment in Pregnant and Lactating Women: A Practical Guide. Humana Press. https://doi.org/10.1007/978-1-60327-439-5_6
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