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Prebiotics, Probiotics, Antibiotics, and Nutritional Therapies in IBD

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Inflammatory Bowel Disease

Part of the book series: Clinical Gastroenterology ((CG))

Abstract

Prebiotics have yielded emerging, promising results in the induction of CD and UC, the most notable of which is germinated barley foodstuffs. Although level 1 evidence is available for the use of probiotics in the induction and maintenance of remission in UC with promising results in pouchitis, it remains unclear why some probiotic strains are effective and others are not. Adjunctive antibiotic therapy is effective at inducing remission in UC, while there are promising results in CD. The effectiveness of this therapy diminishes over time for unknown reasons making it unsuitable for maintenance purposes. Although inferior to corticosteroid therapy for inducing remission, the new diet formulations with increased mucosal healing indicate that nutritional therapies in conjunction with conventional therapies may be a suitable option for certain patients with either CD or UC.

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Authors and Affiliations

  1. Department of Medicine, Centre of Excellence in GastroIntestinal Inflammation Research, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada

    Richard N. Fedorak

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  1. Richard N. Fedorak
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  2. Levinus A. Dieleman
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  3. Karen L. Madsen
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Correspondence to Richard N. Fedorak .

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  1. MC 4076, Sect. Of GE, Hepatol. & Nutr., Department of Medicine, University of Chicago Medical Center, S. Maryland Ave. 5841, Chicago, 60637, Illinois, USA

    Russell D. Cohen

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Fedorak, R.N., Dieleman, L.A., Madsen, K.L. (2011). Prebiotics, Probiotics, Antibiotics, and Nutritional Therapies in IBD. In: Cohen, R. (eds) Inflammatory Bowel Disease. Clinical Gastroenterology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-433-3_9

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  • DOI: https://doi.org/10.1007/978-1-60327-433-3_9

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