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Neuroendocrine Tumors of Prostate, Urinary Bladder and Kidney

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Surgical Pathology of Endocrine and Neuroendocrine Tumors

Part of the book series: Current Clinical Pathology ((CCPATH))

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Abstract

Overall, neuroendocrine tumors in genitourinary system are rare. However, it is crucial to recognize these tumors because patients with neuroendocrine tumors have significant differences in clinical treatment and prognosis from patients with other tumors in the genitourinary system. In this chapter, important neuroendocrine tumors in the prostate, urinary bladder, and kidney are discussed. Highlights also mark imperative elements of each tumor including tumor epidemiology, diagnosis, prognosis, and treatment.

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References

  1. Abrahamsson PA. Neuroendocrine differentiation in prostatic carcinoma. Prostate 1999;39:135–48.

    Article  PubMed  CAS  Google Scholar 

  2. Santamaria L, Martin R, Martin JJ, Alonso L. Stereologic estimation of the number of neuroendocrine cells in normal human prostate detected by immunohistochemistry. Appl Immunohistochem Mol Morphol 2002;10:275–81.

    Article  PubMed  CAS  Google Scholar 

  3. Bonkhoff H. Neuroendocrine differentiation in human prostate cancer. Morphogenesis, proliferation and androgen receptor status. Ann Oncol 2001;12 Suppl 2:S141–4.

    Article  PubMed  Google Scholar 

  4. Sternberg S. Histology for Pathologists. 2nd ed. Philadelphia: Lippincott-Raven; 1997.

    Google Scholar 

  5. Abrahamsson PA, Dizeyi N, Alm P, di Sant'Agnese PA, Deftos LJ, Aumuller G. Calcitonin and calcitonin gene-related peptide in the human prostate gland. Prostate 2000;44:181–6.

    Article  PubMed  CAS  Google Scholar 

  6. Bonkhoff H, Stein U, Remberger K. Endocrine-paracrine cell types in the prostate and prostatic adenocarcinoma are postmitotic cells. Hum Pathol 1995;26:167–70.

    Article  PubMed  CAS  Google Scholar 

  7. di Sant'Agnese PA. Neuroendocrine differentiation in carcinoma of the prostate. Diagnostic, prognostic, and therapeutic implications. Cancer 1992;70:254–68.

    Article  PubMed  Google Scholar 

  8. Aprikian AG, Cordon-Cardo C, Fair WR, Reuter VE. Characterization of neuroendocrine differentiation in human benign prostate and prostatic adenocarcinoma. Cancer 1993;71:3952–65.

    Article  PubMed  CAS  Google Scholar 

  9. di Sant'Agnese PA. Neuroendocrine differentiation in prostatic carcinoma: an update. Prostate Suppl 1998;8:74–9.

    PubMed  Google Scholar 

  10. Abrahamsson PA, Falkmer S, Falt K, Grimelius L. The course of neuroendocrine differentiation in prostatic carcinomas. An immunohistochemical study testing chromogranin A as an “endocrine marker”. Pathol Res Pract 1989;185:373–80.

    Article  PubMed  CAS  Google Scholar 

  11. Stratton M, Evans DJ, Lampert IA. Prostatic adenocarcinoma evolving into carcinoid: selective effect of hormonal treatment? J Clin Pathol 1986;39:750–6.

    Article  PubMed  CAS  Google Scholar 

  12. Cohen RJ, Glezerson G, Haffejee Z, Afrika D. Prostatic carcinoma: histological and immunohistological factors affecting prognosis. Br J Urol 1990;66:405–10.

    Article  PubMed  CAS  Google Scholar 

  13. Helpap B, Kollermann J, Oehler U. Neuroendocrine differentiation in prostatic carcinomas: histogenesis, biology, clinical relevance, and future therapeutical perspectives. Urol Int 1999;62:133–8.

    Article  PubMed  CAS  Google Scholar 

  14. Abrahamsson PA, Cockett AT, di Sant'Agnese PA. Prognostic significance of neuroendocrine differentiation in clinically localized prostatic carcinoma. Prostate Suppl 1998;8:37–42.

    Article  PubMed  CAS  Google Scholar 

  15. de Matteis A. Tissue markers in the diagnosis and prognosis of prostatic carcinoma. Eur Urol 1992;21 Suppl 1:66–70.

    PubMed  Google Scholar 

  16. Wasserstein PW, Goldman RL. Primary carcinoid of prostate. Urology 1979;13:318–20.

    Article  PubMed  CAS  Google Scholar 

  17. Ghannoum JE, DeLellis RA, Shin SJ. Primary carcinoid tumor of the prostate with concurrent adenocarcinoma: a case report. Int J Surg Pathol 2004;12:167–70.

    Article  PubMed  Google Scholar 

  18. Reyes A, Moran CA. Low-grade neuroendocrine carcinoma (carcinoid tumor) of the prostate. Arch Pathol Lab Med 2004;128:e166–8.

    PubMed  Google Scholar 

  19. Tash JA, Reuter V, Russo P. Metastatic carcinoid tumor of the prostate. J Urol 2002;167:2526–7.

    Article  PubMed  Google Scholar 

  20. Whelan T, Gatfield CT, Robertson S, Carpenter B, Schillinger JF. Primary carcinoid of the prostate in conjunction with multiple endocrine neoplasia IIb in a child. J Urol 1995;153:1080–2.

    Article  PubMed  CAS  Google Scholar 

  21. Wang W, Epstein JI. Small cell carcinoma of the prostate. A morphologic and immunohistochemical study of 95 cases. Am J Surg Pathol 2008;32:65–71.

    Article  PubMed  Google Scholar 

  22. Miyoshi Y, Uemura H, Kitami K, Satomi Y, Kubota Y, Hosaka M. Neuroendocrine differentiated small cell carcinoma presenting as recurrent prostate cancer after androgen deprivation therapy. BJU Int 2001;88:982–3.

    Article  PubMed  CAS  Google Scholar 

  23. Turbat-Herrera EA, Herrera GA, Gore I, Lott RL, Grizzle WE, Bonnin JM. Neuroendocrine differentiation in prostatic carcinomas. A retrospective autopsy study. Arch Pathol Lab Med 1988;112:1100–5.

    PubMed  CAS  Google Scholar 

  24. Shah RB, Mehra R, Chinnaiyan AM, et al. Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program. Cancer Res 2004;64:9209–16.

    Article  PubMed  CAS  Google Scholar 

  25. Helpap B, Kollermann J. Undifferentiated carcinoma of the prostate with small cell features: immunohistochemical subtyping and reflections on histogenesis. Virchows Arch 1999;434:385–91.

    Article  PubMed  CAS  Google Scholar 

  26. Ro JY, Tetu B, Ayala AG, Ordonez NG. Small cell carcinoma of the prostate. II. Immunohistochemical and electron microscopic studies of 18 cases. Cancer 1987;59:977–82.

    Article  PubMed  CAS  Google Scholar 

  27. Fernandes RC, Matsushita MM, Mauad T, Nascimento Saldiva PH. Prostate carcinoma with neuroendocrine differentiation: case report and literature review. Rev Hosp Clin Fac Med Sao Paulo 2001;56:153–8.

    Article  PubMed  CAS  Google Scholar 

  28. Patel S, Rosenthal JT. Hypercalcemia in carcinoma of prostate. Its cure by orchiectomy. Urology 1985;25:627–9.

    Article  PubMed  CAS  Google Scholar 

  29. Wynn SS, Nagabundi S, Koo J, Chin NW. Recurrent prostate carcinoma presenting as omental large cell carcinoma with neuroendocrine differentiation and resulting in bowel obstruction. Arch Pathol Lab Med 2000;124:1074–6.

    PubMed  CAS  Google Scholar 

  30. Evans AJ, Humphrey PA, Belani J, van der Kwast TH, Srigley JR. Large cell neuroendocrine carcinoma of prostate: a clinicopathologic summary of 7 cases of a rare manifestation of advanced prostate cancer. Am J Surg Pathol 2006;30:684–93.

    Article  PubMed  Google Scholar 

  31. Cheng L, Leibovich BC, Cheville JC, et al. Paraganglioma of the urinary bladder: can biologic potential be predicted? Cancer 2000;88:844–52.

    Article  PubMed  CAS  Google Scholar 

  32. Eble J, Sauter G, Epstein J, Sesterhenn I. WHO Tumors of the Urinary System and Male Genital Organs: WHO, IARC Press; 2004.

    Google Scholar 

  33. Leestma JE, Price EB, Jr. Paraganglioma of the urinary bladder. Cancer 1971;28:1063–73.

    Article  PubMed  CAS  Google Scholar 

  34. Linnoila RI, Keiser HR, Steinberg SM, Lack EE. Histopathology of benign versus malignant sympathoadrenal paragangliomas: clinicopathologic study of 120 cases including unusual histologic features. Hum Pathol 1990;21:1168–80.

    Article  PubMed  CAS  Google Scholar 

  35. Murphy W, Beckwith J, Farrow G. Atlas of Tumor Pathology. Tumors of the Kidney, Bladder, and Related Urinary Structures. 3rd ed. Washington, D.C: AFIP; 1994.

    Google Scholar 

  36. Davaris P, Petraki K, Arvanitis D, Papacharalammpous N, Morakis A, Zorzos S. Urinary bladder paraganglioma (U.B.P.). Pathol Res Pract 1986;181:101–6.

    Article  PubMed  CAS  Google Scholar 

  37. Grignon DJ, Ro JY, Mackay B, et al. Paraganglioma of the urinary bladder: immunohistochemical, ultrastructural, and DNA flow cytometric studies. Hum Pathol 1991;22:1162–9.

    Article  PubMed  CAS  Google Scholar 

  38. Bostwick DG, Eble J. Urologic Surgical Pathology. St. Louis: Mosby; 1997.

    Google Scholar 

  39. Holmang S, Borghede G, Johansson SL. Primary small cell carcinoma of the bladder: a report of 25 cases. J Urol 1995;153:1820–2.

    Article  PubMed  CAS  Google Scholar 

  40. Lohrisch C, Murray N, Pickles T, Sullivan L. Small cell carcinoma of the bladder: long term outcome with integrated chemoradiation. Cancer 1999;86:2346–52.

    Article  PubMed  CAS  Google Scholar 

  41. Grignon DJ, Ro JY, Ayala AG, et al. Small cell carcinoma of the urinary bladder. A clinicopathologic analysis of 22 cases. Cancer 1992;69:527–36.

    Article  PubMed  CAS  Google Scholar 

  42. Cheng L, Pan CX, Yang XJ, et al. Small cell carcinoma of the urinary bladder: a clinicopathologic analysis of 64 patients. Cancer 2004;101:957–62.

    Article  PubMed  Google Scholar 

  43. Oesterling JE, Brendler CB, Burgers JK, Marshall FF, Epstein JI. Advanced small cell carcinoma of the bladder. Successful treatment with combined radical cystoprostatectomy and adjuvant methotrexate, vinblastine, doxorubicin, and cisplatin chemotherapy. Cancer 1990;65:1928–36.

    Article  PubMed  CAS  Google Scholar 

  44. Choong NW, Quevedo JF, Kaur JS. Small cell carcinoma of the urinary bladder. The Mayo Clinic experience. Cancer 2005;103:1172–8.

    Article  PubMed  Google Scholar 

  45. Hansel DE, Epstein JI, Berbescu E, Fine SW, Young RH, Cheville JC. Renal carcinoid tumor: a clinicopathologic study of 21 cases. Am J Surg Pathol 2007;31:1539–44.

    Article  PubMed  Google Scholar 

  46. Acconcia A, Miracco C, Mattei FM, deSanti MM, Del Vecchio MT, Luzi P. Primary carcinoid tumor of kidney. Light and electron microscopy, and immunohistochemical study. Urology 1988;31:517–20.

    Article  PubMed  CAS  Google Scholar 

  47. Ghazi MR, Brown JS, Warner RS. Carcinoid tumor of kidney. Urology 1979;14:610–2.

    Article  PubMed  CAS  Google Scholar 

  48. Zak FG, Jindrak K, Capozzi F. Carcinoidal tumor of the kidney. Ultrastruct Pathol 1983;4:51–9.

    Article  PubMed  CAS  Google Scholar 

  49. Majhail NS, Elson P, Bukowski RM. Therapy and outcome of small cell carcinoma of the kidney: report of two cases and a systematic review of the literature. Cancer 2003;97:1436–41.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. University of Massachusetts Medical School, Three Biotech, One Innovation Drive, Worcester, MA, USA

    Zhong Jiang (Professor of Pathology, Director, Genitourinary Pathology)

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  1. Zhong Jiang
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Correspondence to Zhong Jiang .

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Editors and Affiliations

  1. School (UMMS), University of Massachusetts Medical, Lake Avenue N. 55, Worcester, 01655, U.S.A.

    Ashraf Khan

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Jiang, Z. (2009). Neuroendocrine Tumors of Prostate, Urinary Bladder and Kidney. In: Khan, A. (eds) Surgical Pathology of Endocrine and Neuroendocrine Tumors. Current Clinical Pathology. Humana Press. https://doi.org/10.1007/978-1-60327-396-1_15

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  • DOI: https://doi.org/10.1007/978-1-60327-396-1_15

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-395-4

  • Online ISBN: 978-1-60327-396-1

  • eBook Packages: MedicineMedicine (R0)

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