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Under normal conditions glucose and fat oxidation within the metabolic pathways “fuels” ATP resynthesis (protein plays a limited role as a fuel). Glucose is unique because unlike fat its energy content is exploited by anaerobic metabolism in addition to aerobic metabolism. Fat oxidation is completely aerobic. Anaerobic metabolism, as its name implies, does not involve oxygen. However, the products of anaerobic metabolism — pyruvate and lactate — can undergo complete oxidation aerobically; but that is a later story (Chap. 11). In fact, biochemistry was a borne anaerobic baby and grew to become an aerobic adult. Let us start from the beginning …

10.1 A Brief History of Anaerobic Biochemistry

For literally thousands of years, prevailing thought held that heat was a prerequisite for life. It was Jean Baptiste van Helmont (1577–1644) who declared things the other way around: life produced heat. The warmth rising from the fermentation of wine — the splitting of glucose to form alcohol — was...

Keywords

Enthalpy Change Anaerobic Metabolism Anaerobic Glycolysis Gibbs Energy Change Metabolic Power 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Stryer L. Biochemistry, 3rd ed. New York: W.H. Freeman and Co., 1988.Google Scholar
  2. 2.
    McArdle WD, Katch FI, Katch VL. Essentials of exercise physiology, 2nd ed. Philadelphia: Lippincott, Williams & Wilkins, 2000.Google Scholar
  3. 3.
    Gnaiger E. Heat dissipation and energetic efficiency in animal anoxibiosis: economy contra power. J Exp Biol. 1983;228:471–490.Google Scholar
  4. 4.
    di Prampero PE, Meyer M, Cerretelli P, et al. Energetics of anaerobic glycolysis in dog gas-trocnemius muscle. Pflugers Arch. 1978;377:1–8.CrossRefGoogle Scholar
  5. 5.
    Minakami S, de Verdier C-H. Calorimetric study on human erythrocyte glycolysis: heat production in various metabolic conditions. Eur J Biochem. 1976;65:451–460.CrossRefGoogle Scholar
  6. 6.
    Dyer BD, Obar RA. Tracing the history of eukaryotic cells: the enigmatic smile. New York: Columbia University Press, 1994.Google Scholar
  7. 7.
    Bereiter-Hahn J, Airas J, Blum S. Supramolecular associations with the cytomatrix and their relevance in metabolic control: protein synthesis and glycolysis. Zoology. 1997;100:1–24.Google Scholar
  8. 8.
    Conley KE, Blei ML, Richards TL, et al. Activation of glycolysis in human muscle in vivo. Am J Physiol. 1997;273:C306–C315.Google Scholar
  9. 9.
    Wilkie DR. The control of glycolysis in living muscle studied by nuclear magnetic resonance and other techniques. Biochem Soc Trans. 1983;11:244–246.Google Scholar
  10. 10.
    Westerhoff HV, van Echteld CJA, Jeneson JAL. On the expected relationship between Gibbs energy of ATP hydrolysis and muscle performance. Biophys Chem. 1995;54:137–142.CrossRefGoogle Scholar
  11. 11.
    Jeneson JAL, Westerhoff HV, Kushmerick MJ. A metabolic control analysis of kinetic controls in ATP free energy metabolism in contracting skeletal muscle. Am J Physiol Cell Physiol. 2000;279:C813–C832.Google Scholar
  12. 12.
    Gnaiger E. Physiological calorimetry: heat flux, metabolic flux, entropy and power. Ther-mochim Acta. 1989;151:23–34.CrossRefGoogle Scholar
  13. 13.
    Kemp RB. Importance of the calorimetric—respirometric ratio in studying intermediary metabolism of cultured mammalian cells. Thermochim Acta. 1990;172:61–73.CrossRefGoogle Scholar
  14. 14.
    Scott CB, Kemp RB. Direct and indirect calorimetry of lactate oxidation: implications for whole-body energy expenditure. J Sports Sci. 2005;23:15–19.CrossRefGoogle Scholar
  15. 15.
    Wiegert RG. Thermodynamic considerations in animal nutrition. Am Zoologist. 1968;8:71–81.Google Scholar
  16. 16.
    Toussaint O, Schneider ED. The thermodynamics and evolution of complexity in biological systems. Comp Biochem Physiol A. 1998;120:3–9.CrossRefGoogle Scholar
  17. 17.
    Wilkie DR. Heat work and phosphorylcreatine break-down in muscle. J Physiol. 1968;195:157–183.Google Scholar
  18. 18.
    Pahud P, Ravussin E, Achesin KJ, et al. Energy expended during oxygen deficit of submaximal concentric and eccentric exercise. J Appl Physiol. 1980;49:16–21.Google Scholar
  19. 19.
    Gebert G, Sydney MF. An implantable glass electrode used for pH measurement in working skeletal muscle. J Appl Physiol. 1973;34:122–124.Google Scholar
  20. 20.
    McMahon S, Jenkins D. Factors affecting the rate of phosphocreatine resynthesis following intense exercise. Sports Med. 2002;32:761–784.CrossRefGoogle Scholar
  21. 21.
    Hultman E, Sjoholm H. Energy metabolism and contraction force of human muscle in situ during electrical stimulation. J Physiol. 1983;345:525–532.Google Scholar
  22. 22.
    McGilvery RW. Biochemical concepts. Philadelphia: W.B. Saunders Co., 1975.Google Scholar
  23. 23.
    Hochachka PW. Fuels and pathways as designed systems for support of muscular work. J Exp Biol. 1985;115:149–164.Google Scholar
  24. 24.
    Hultman E, Sjoholm H. Substrate availability. In, Knuttgen HG, Vogel JA, Poortmans, J, eds. Biochemistry of exercise; vol. 5. Champaign, IL: Human Kinetics Publ., 1983, pp 63–75.Google Scholar
  25. 25.
    Jones NL, McCartney N, Graham T, et al. Muscle performance and metabolism in maximal isokinetic cycling at slow and fast speeds. J Appl Physiol. 1985;59:132–136.Google Scholar
  26. 26.
    Spriet LL. Anaerobic metabolism during high-intensity exercise. In, Hargreaves M., ed., Exercise metabolism. Champaign, IL: Human Kinetics Publ., 1995, pp 1–40.Google Scholar
  27. 27.
    Gnaiger E. Efficiency and power strategies under hypoxia. Is low efficiency at high glycolytic ATP production a paradox? In, Hochachka PW, Lutz P, Sick T, Rosenthal M, van den Thillart, G, eds., Surviving hypoxia: mechanisms of control and adaptation. Boca Raton: CRC, 1993, pp 77–109.Google Scholar
  28. 28.
    Shulman RG, Rothman DL. The “glycogen shunt” in exercising muscle: a role for glycogen in muscle energetics and fatigue. Proc Nat Acad Sci. 2001;98:457–461.CrossRefGoogle Scholar

Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Christopher B. Scott
    • 1
  1. 1.GorhamUSA

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