Structural Biology of Programmed Cell Death

  • Yigong ShiEmail author


Structural and biochemical characterization on death receptors, Bcl-2 family proteins, caspases, IAPs, Smac/DIABLO, and other regulatory proteins has revealed significant insights into the molecular mechanisms of apoptosis. This chapter summarizes these advances and presents our current understanding of apoptosis from a structural and mechanistic perspective.


Macromolecule structure Bcl-2 family proteins Inhibitor-of-apoptosis proteins Smac DIABLO Death receptor 


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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Molecular Biology, Lewis Thomas LaboratoryPrinceton UniversityPrincetonUSA

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