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Dopamine Receptor Subtype-Selective Drugs: D2-Like Receptors

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Part of the The Receptors book series (REC)

Abstract

Drugs that are known to activate or block dopamine receptors are widely used for the treatment of a number of severe diseases. In most cases, dopaminergic drugs preferentially interact with the subtypes of the D2 family (D2, D3, D4). However, only minor selectivity has been observed between D2, D3, and D4. Nevertheless, in recent years D3 and D4 subtype-selective agonists, partial agonists, and antagonist have been developed. The most interesting structural features required for high selectivity and affinity are presented as well as structure–activity relationship (SAR) studies. Moreover, the use of subtype-selective radioligands is discussed.

Keywords

  • D2-like receptors
  • subtype selectivity
  • aminotetralins
  • phenylpiperazines
  • radioligands
  • D3-receptors
  • D4-receptors

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  • DOI: 10.1007/978-1-60327-333-6_5
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© 2010 Humana Press, a part of Springer Science+Business Media, LLC

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Prante, O., Dörfler, M., Gmeiner, P. (2010). Dopamine Receptor Subtype-Selective Drugs: D2-Like Receptors. In: Neve, K. (eds) The Dopamine Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-333-6_5

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