Abstract
Microscopic polyangiitis (MPA) belongs to the antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAVs). MPA is clinically characterized by small-vessel vasculitis primarily affecting the kidneys and the lungs, but other organs may be involved as well. Renal involvement, which can be the only manifestation, is clinically apparent as rapidly progressive glomerulonephritis and histopathologically as pauci-immune necrotizing and crescentic glomerulonephritis. ANCAs in MPA are mainly directed to myeloperoxidase (MPO-ANCA). Induction treatment consists of cyclophosphamide and steroids followed by azathioprine as maintenance therapy. Other, less toxic therapeutic regimens are being tested.
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© 2008 Humana Press, a part of Springer Science+Business Media, LLC
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Kallenberg, C.G. (2008). Microscopic Polyangiitis. In: Shoenfeld, Y., Cervera, R., Gershwin, M.E. (eds) Diagnostic Criteria in Autoimmune Diseases. Humana Press. https://doi.org/10.1007/978-1-60327-285-8_17
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DOI: https://doi.org/10.1007/978-1-60327-285-8_17
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