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mTOR Pathway and mTOR Inhibitors in Cancer Therapy pp 217–236Cite as

Genome-Wide Analysis of Translational Control

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

The importance of translational deregulation of specific transcripts in cancer has emerged during the last decade. For a more complete understanding of translational control in cancer, genome-wide studies of translational control are essential. In this chapter we describe methods that make such analysis possible and identify several key aspects of experimental design and data analysis which are essential for an informative study. We further review several studies that have used such approaches to gain insights in genome-wide translational control in cancer models with particular focus on genome-wide translational deregulation downstream of eIF4E. Finally we introduce “integrative translatomics” as a means to link genome-wide translational patterns to molecular mechanisms originating from the RNA sequences. This information may prove to be essential for a comprehensive understanding of how pathological translational control mediates the acquisition of a malignant phenotype.

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Acknowledgments

O.L. is supported by a fellowship from the Knut and Alice Wallenberg Foundation.

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Authors and Affiliations

  1. Department of Oncology-Pathology, Karolinska Institute, Cancer Center Karolinska R8:01, 171 76, Stockholm, Sweden

    Ola Larsson

  2. Department of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA

    Peter B. Bitterman

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  1. Ola Larsson
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  2. Peter B. Bitterman
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Correspondence to Ola Larsson .

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Editors and Affiliations

  1. Dept. Family Medicine, University of Minnesota, Minneapolis, 55455, USA

    Vitaly A. Polunovsky

  2. Director, Center for Childhood Cancer, Nationwide Children’s Hospital, The Research Institute, 700 Children’s Drive 332, Columbus, 43205, USA

    Peter J. Houghton

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Larsson, O., Bitterman, P.B. (2009). Genome-Wide Analysis of Translational Control. In: Polunovsky, V., Houghton, P. (eds) mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-271-1_11

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  • DOI: https://doi.org/10.1007/978-1-60327-271-1_11

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60327-270-4

  • Online ISBN: 978-1-60327-271-1

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