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Regulation of G-Protein-Coupled Receptor (GPCR) Trafficking in the Striatum in Parkinson’s Disease

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Cortico-Subcortical Dynamics in Parkinson's Disease

Part of the book series: Contemporary Neuroscience ((CNEURO))

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The striatum is a key element of basal ganglia involved in motor activity and cognitive function [1]. Dysregulation of its activity and/or physiology is involved in neurodegenerative diseases such as Parkinson’s and Huntington’s diseases and behavioural abnormalities such as addiction. Striatum is under the control of cortical, thalamic and nigral inputs and locally released neurotransmitter, i.e. GABA, acetylcholine, substance P enkephalins [2, 3]. Among many others, two key parameters that control neuronal activity and responsiveness are the abundance of neurotransmitter in the local environment and the density and availability of the receptors at the plasma membrane.

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Abbreviations

GABA::

gamma-aminobutyric acid

GPCR::

G-protein-coupled receptor

GRK::

G-protein-linked receptor kinase

MAPK::

mitogen-activated protein kinase

D1R::

dopamine receptor 1

DR5::

dopamine receptor 5

D2R::

dopamine receptor 2

D3R::

dopamine receptor 3

D4R::

dopamine receptor 4

cAMP::

adenosine 3',5'-cyclic monophosphate

PD::

Parkinson’s disease

6-OH-DA::

6-hydroxydopamine

LID::

levodopa-induced dyskinesia

MPTP::

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

DA::

dopamine

NMDAR::

N-methyl-d-aspartate receptor

NR1::

NMDA receptor subunit 1

NR2A::

NMDA receptor subunit 2A

NR2B::

NMDA receptor subunit 2B

DARPP32::

dopamine- and cAMP-regulated phosphoprotein 32 kDa

PSD95::

postsynaptic density protein-95

PSD::

postsynaptic density

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Authors and Affiliations

  1. Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Université Victor Segalen Bordeaux 2, 146 rue leo saignat, 33076 Bordeaux cedex, France

    Erwan Bézard

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  1. Marie-Laure Martin-Negrier
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  2. Céline Guigoni
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  3. Bertrand Bloch
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  4. Erwan Bézard
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Correspondence to Erwan Bézard .

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    Martin-Negrier, ML., Guigoni, C., Bloch, B., Bézard, E. (2009). Regulation of G-Protein-Coupled Receptor (GPCR) Trafficking in the Striatum in Parkinson’s Disease. In: Tseng, KY. (eds) Cortico-Subcortical Dynamics in Parkinson's Disease. Contemporary Neuroscience. Humana Press. https://doi.org/10.1007/978-1-60327-252-0_17

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