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The Effect of Pregnancy on Energy Metabolism, Body Composition, and Endothelial Function

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Diabetes in Women

Part of the book series: Contemporary Diabetes ((CDI))

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Abstract

Maternal adaptations in energy metabolism are required to respond to the additional energy demands of pregnancy, and these adaptations are influenced by the degree of maternal obesity. Glucose intolerance does not influence the adaptation of maternal energy metabolism to pregnancy. Pregnancy is associated with increased maternal insulin resistance, which is further increased in obese and glucose-intolerant mothers. Endothelial function is improved in pregnancy but to a lesser extent in obese and glucose-intolerant mothers. While these changes in maternal metabolism and physiology in response to pregnancy have been described, the timing and the resulting impact on the quality of circulating maternal metabolites are poorly understood. An appreciation of the detail of these processes is important in order to inform our understanding of how obesity and glucose intolerance may contribute to adverse pregnancy outcome and to allow the development of sensible, evidence-based prevention strategies.

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Author information

Authors and Affiliations

  1. Reproductive and Maternal Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK

    Dilys J. Freeman

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  1. Dilys J. Freeman
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  2. Naveed Sattar
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  1. Dept. Medicine, University Ioannina, Ioannina, 455 10, Greece

    Agathocles Tsatsoulis

  2. Dept. Internal Medicine, University of Michigan, E. Medical Center Dr. 1500, Ann Arbor, 48109-0354, U.S.A.

    Jennifer Wyckoff

  3. Dept. Medicine, Harvard Medical School, Joslin Place 1, Boston, 02215, U.S.A.

    Florence M. Brown

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Freeman, D.J., Sattar, N. (2009). The Effect of Pregnancy on Energy Metabolism, Body Composition, and Endothelial Function. In: Tsatsoulis, A., Wyckoff, J., Brown, F. (eds) Diabetes in Women. Contemporary Diabetes. Humana Press. https://doi.org/10.1007/978-1-60327-250-6_11

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