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Sodium Transport Mechanisms in the Mammalian Nephron

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Epithelial Transport Physiology

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Abstract

Na transport is highly coordinated and regulated along the length of the renal nephron. The proximal tubule reabsorbs the majority of filtered Na. The majority of Na transport is transcellular, through the action of Na-antiporters and Na-coupled cotransporters. The proximal tubule is responsible for the majority of Na reabsorption by the renal nephron. In the thick ascending limb of Henle, Na is cotransported with other ions. This nephron segment is critical for urine concentration. The distal tubule and collecting duct make the smallest contribution to renal Na reabsorption. However, Na transport in these segments is subject to stringent regulation and is critical for external Na balance under normal physiological conditions. The basic structure and function of the renal Na transporters are evaluated. Hormonal and signaling pathways that regulate Na transport in the nephron and collecting duct are also discussed.

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Acknowledgments

We would like to acknowledge the Medical Media Service of the Malcolm Randall Veterans Affairs Medical Center for their help with the illustrations in this chapter.

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Authors and Affiliations

  1. Wingo Laboratory, Veteran Affairs Medical Center, 32608, Gainesville, FL, USA

    Michelle L. Gumz

  2. Department of Physiology and Functional Genomics, Malcolm Randall Veterans Affairs Medical Center, University of Florida College of Medicine, Gainesville, FL, USA

    Lisa R. Stow

  3. Division of Nephrology, Hypertension and Transplantation, and Department of Physiology and Functional Genomics, Malcolm Randall Veterans Affairs Medical Center, University of Florida College of Medicine, Gainesville, FL, USA

    Shen-Ling Xia

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  1. Michelle L. Gumz
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  2. Lisa R. Stow
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  3. Shen-Ling Xia
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Correspondence to Michelle L. Gumz .

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  1. College of Medicine, University of Florida, SW. Archer Road 1600, Gainesville, 32610-0274, U.S.A.

    George A. Gerencser

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Gumz, M.L., Stow, L.R., Xia, SL. (2010). Sodium Transport Mechanisms in the Mammalian Nephron. In: Gerencser, G. (eds) Epithelial Transport Physiology. Humana Press. https://doi.org/10.1007/978-1-60327-229-2_12

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