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Acid/Base Regulation in Renal Epithelia by H,K-ATPases

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Epithelial Transport Physiology

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Abstract

The renal H,K-ATPases are integral membrane proteins, located in the renal collecting duct (CD) and other segments of the nephron, that participate in the regulation of proton secretion and cation reabsorption. Together with the apical Na/H exchangers and the H-ATPases, the H,K-ATPases, function as proton secretory mechanisms that are responsible for reclamation of filtered HCO3, regeneration of HCO3 consumed in the oxidation of the products of metabolism, and the generation of new HCO3 in the kidney. This chapter examines the role of H,IC-ATPases in acidbase and volume homeostasis. We discuss the H,K-ATPase holoenzyme structure followed by a review of studies regarding renal H,K-ATPase localization, function, and regulation. Finally, a recent report using a genetic approach to quantify the contribution of two a-subunit isoforms of the H,K-ATPase to acid secretion has confirmed years of pharmacological studies from many laboratories and demonstrates that both isoforms of this enzyme are normally active in the CD.

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Authors and Affiliations

  1. North Florida/South Georgia Veterans Health System and College of Medicine, University of Florida, 32608, Gainesville, FL, USA

    I. Jeanette Lynch & Charles S. Wingo

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  1. I. Jeanette Lynch
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  2. Charles S. Wingo
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Correspondence to Charles S. Wingo .

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  1. College of Medicine, University of Florida, SW. Archer Road 1600, Gainesville, 32610-0274, U.S.A.

    George A. Gerencser

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Lynch, I.J., Wingo, C.S. (2010). Acid/Base Regulation in Renal Epithelia by H,K-ATPases. In: Gerencser, G. (eds) Epithelial Transport Physiology. Humana Press. https://doi.org/10.1007/978-1-60327-229-2_11

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