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Head and Neck Cancer: An Example for the Role of Chemokine Receptors in Tumor Progression and Metastasis

  • Chapter
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From Local Invasion to Metastatic Cancer

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

Despite ongoing advances in cancer therapy, a large number of patients are still afflicted with metastatic disease, the most lethal aspect of human cancer. Thus, understanding the factors that promote tumor metastasis is a critical area in cancer research. Recent findings demonstrate that tumor cells adopt chemokine receptor-mediated pathways from leukocytes to perform organ-specific metastasis. Here, we summarize recent advances in head and neck cancer (HNC) and describe the role of chemokine receptors in tumor progression and metastasis.

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Authors and Affiliations

  1. Department of Radiation Oncology, Heinrich Heine University, Düsseldorf, Germany

    Anja Muller MD

  2. Department of Dermatology, Heinrich Heine University, Düsseldorf, Germany

    Bernhard Homey MD

  3. Departments of Otolarygology and Immunology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

    Robert L. Ferris MD, PhD, FACS

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  1. Anja Muller MD
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  2. Bernhard Homey MD
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  3. Robert L. Ferris MD, PhD, FACS
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Editor information

Editors and Affiliations

  1. Division of Surgical Oncology, University of California, San Francisco, Divisadero St. 1600, San Francisco, 94115, USA

    Stanley P. L. Leong

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Muller, A., Homey, B., Ferris, R.L. (2009). Head and Neck Cancer: An Example for the Role of Chemokine Receptors in Tumor Progression and Metastasis. In: Leong, S. (eds) From Local Invasion to Metastatic Cancer. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-087-8_22

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  • DOI: https://doi.org/10.1007/978-1-60327-087-8_22

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60327-086-1

  • Online ISBN: 978-1-60327-087-8

  • eBook Packages: MedicineMedicine (R0)

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