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Transplantation of Bone Marrow Stromal Cells for the Treatment of Stroke

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Stroke Recovery with Cellular Therapies

Part of the book series: Current Clinical Neurology ((CCNEU))

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Reference

  1. N. Duggal, R. Schmidt-Kastner and A. M. Hakim, Nestin expression in reactive astrocytes following focal cerebral ischemia in rats, Brain Res 768, 1–9 (1997).

    Article  PubMed  CAS  Google Scholar 

  2. Y. Li and M. Chopp, Temporal profile of nestin expression after focal cerebral ischemia in adult rat, Brain Res 838, 1–10 (1999).

    Article  PubMed  CAS  Google Scholar 

  3. R. P. Stroemer, T. A. Kent and C. E. Hulsebosch, Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats, Stroke 26(11), 2135–2144 (1995).

    PubMed  CAS  Google Scholar 

  4. Y. Li, N. Jiang, C. Powers and M. Chopp, Neuronal damage and plasticity identified by microtubule-associated protein 2, growth-associated protein 43, and cyclin d1 immunoreactivity after focal cerebral ischemia in rats, Stroke 29(9), 1972–1980 (1998).

    PubMed  CAS  Google Scholar 

  5. L. H Shen, Y. Li, J. Chen, J. Zhang, P. Vanguri, J. Borneman and M. Chopp, Intracarotid transplantation of bone marrow stromal cells increases axonmyelin remodeling after stroke, Neuroscience 137, 393–399 (2006).

    Article  PubMed  CAS  Google Scholar 

  6. Z. Zhang and M. Chopp, Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia, Trends Cardiovasc Med 12(2), 62–66 (2002).

    Article  PubMed  CAS  Google Scholar 

  7. J. Chen, Y. Li, M. Katakowski, X. Chen, L. Wang, D. Lu, M. Lu, S. C. Gautam and M. Chopp, Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat, J Neurosci Res 73(6), 778–786 (2003).

    Article  PubMed  CAS  Google Scholar 

  8. R. Zhang, Z. Zhang, L. Wang, Y. Wang, A. Gousev, L. Zhang, K. L. Ho, C. Morshead and M. Chopp, Activated neural stem cells contribute to stroke-induced neurogenesis and neuroblast migration toward the infarct boundary in adult rats, J Cereb Blood Flow Metab 24(4), 441–448 (2004).

    Article  PubMed  Google Scholar 

  9. G. Kempermann, H. van Praag and F. H. Gage, Activity-dependent regulation of neuronal plasticity and self repair, Prog Brain Res 127, 35–48 (2000).

    Article  PubMed  CAS  Google Scholar 

  10. S. E. Haynesworth, M. A. Baber and A. I. Caplan, Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: Effects of dexamethasone and il-1 alpha, J Cell Physiol 166(3), 585–592 (1996).

    Article  PubMed  CAS  Google Scholar 

  11. S. P. Dormady, O. Bashayan, R. Dougherty, X. M. Zhang and R. S. Basch, Immortalized multipotential mesenchymal cells and the hematopoietic microenvironment, J Hematother Stem Cell Res 10(1), 125–140 (2001).

    Article  PubMed  CAS  Google Scholar 

  12. J. Rohwedel, K. Guan, W. Zuschratter, S. Jin, G. Ahnert-Hilger, D. Furst, R. Fassler and A. M. Wo-bus, Loss of beta1 integrin function results in a retardation of myogenic, but an acceleration of neuronal, differentiation of embryonic stem cells in vitro, Dev Biol 201(2), 167–184 (1998).

    Article  PubMed  CAS  Google Scholar 

  13. J. Chen, Y. Li, L. Wang, Z. Zhang, D. Lu, M. Lu and M. Chopp, Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats, Stroke 32(4), 1005–1011 (2001).

    PubMed  CAS  Google Scholar 

  14. J. Chen, Y. Li, L. Wang, M. Lu, X. Zhang and M. Chopp, Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats, J Neurol Sci 189, 49–57 (2001).

    Article  PubMed  CAS  Google Scholar 

  15. Y. Li, J. Chen, L. Wang, M. Lu and M. Chopp, Treatment of stroke in rat with intracarotid administration of marrow stromal cells, Neurology 56(12), 1666–1672 (2001).

    PubMed  CAS  Google Scholar 

  16. Y. Li, J. Chen, X. G. Chen, L. Wang, S. C. Gautam, Y. X. Xu, M. Katakowski, L. J. Zhang, M. Lu, N. Janakiraman and M. Chopp, Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery, Neurology 59(4), 514–523 (2002).

    PubMed  CAS  Google Scholar 

  17. J. Chen, Y. Li, R. Zhang, M. Katakowski, S. C. Gautam, Y. Xu, M. Lu, Z. Zhang and M. Chopp, Combination therapy of stroke in rats with a nitric oxide donor and human bone marrow stromal cells enhances angiogenesis and neurogenesis, Brain Res 1005, 21–28 (2004).

    Article  PubMed  CAS  Google Scholar 

  18. Y. Li, J. Chen, C. L. Zhang, L. Wang, D. Lu, M. Katakowski, Q. Gao, L. H. Shen, J. Zhang, M. Lu and M. Chopp, Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells, Glia 49(3), 407–417 (2005).

    Article  PubMed  Google Scholar 

  19. Y. Li, J. Chen and M. Chopp, Adult bone marrow transplantation after stroke in adult rats, Cell Transplant 10(1), 31–40 (2001).

    PubMed  CAS  Google Scholar 

  20. Y. Li, M. Chopp, J. Chen, L. Wang, S. C. Gautam, Y. X. Xu and Z. Zhang, Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice, J Cereb Blood Flow Metab 20(9), 1311–1319 (2000).

    Article  PubMed  CAS  Google Scholar 

  21. J. H. Garcia, Y. Yoshida, H. Chen, Y. Li, Z. G. Zhang, J. Lian, S. Chen and M. Chopp, Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat, Am J Pathol 142(2), 623–635 (1993).

    PubMed  CAS  Google Scholar 

  22. Y. Li, V. G. Sharov, N. Jiang, C. Zaloga, H. N. Sabbah and M. Chopp, Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat, A m J Pathol 146(5), 1045–1051 (1995).

    CAS  Google Scholar 

  23. Y. Li, M. Chopp, N. Jiang, F. Yao and C. Zaloga, Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat, J Cereb Blood Flow Metab 15(3), 389–397 (1995).

    PubMed  CAS  Google Scholar 

  24. Y. Li, M. Chopp, J. H. Garcia, Y. Yoshida, Z. G. Zhang and S. R. Levine, Distribution of the 72-kd heat-shock protein as a function of transient focal cerebral ischemia in rats, Stroke 23(9), 1292–1298 (1992).

    PubMed  CAS  Google Scholar 

  25. Y. Li, M. Chopp, Z. G. Zhang, C. Zaloga, L. Niewenhuis and S. Gautam, P53-immunoreactive protein and p53 mrna expression after transient middle cerebral artery occlusion in rats, Stroke 25(4), 849–855 (1994).

    PubMed  CAS  Google Scholar 

  26. Y. Li, M. Chopp, C. Powers and N. Jiang, Immunoreactivity of cyclin d1/cdk4 in neurons and oligodendrocytes after focal cerebral ischemia in rat, J Cereb Blood Flow Metab 17(8), 846–856 (1997).

    Article  PubMed  CAS  Google Scholar 

  27. R. L. Zhang, M. Chopp, Y. Li, C. Zaloga, N. Jiang, M. L. Jones, M. Miyasaka and P. A. Ward, Anti-icam-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat, Neurology 44(9), 1747–1751 (1994).

    PubMed  CAS  Google Scholar 

  28. Z. G. Zhang, M. Chopp, F. Bailey and T. Malinski, Nitric oxide changes in the rat brain after transient middle cerebral artery occlusion, J Neurol Sci 128(1), 22–27 (1995).

    Article  PubMed  CAS  Google Scholar 

  29. Z. G. Zhang, L. Zhang, Q. Jiang and M. Chopp, Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse, Circ Res 90(3), 284–288 (2002).

    Article  PubMed  CAS  Google Scholar 

  30. Y. Li, K. McIntosh, J. Chen, C. Zhang, Q. Gao, J. Borneman, K. Raginski, L. H. Shen, J. Zhang, D. Lu, and M. Chopp, Allogeneic bone marrow stromal cells promote glial-axonal remodeling without immuologic sensitization after stroke in rats, Exp Neurol 198, 313–325.

    Google Scholar 

  31. K. R. McIntosh, K. Beggs, R. Dodds, A. Lyubimov, A. Bartholomew, C. Cobbs, A. Smith and A. Moseley, High dose administration of allogeneic mesenchymal stem cells to immunocompetent baboons. Suppl Bone Marrow Transplant 29, S38 (Abstract) (2002).

    Google Scholar 

  32. W. T. Tse, J. D. Pendleton, W. M. Beyer, M. C. Egalka and E. C. Guinan, Suppression of allogeneic t-cell proliferation by human marrow stromal cells: Implications in transplantation, Transplantation 75(3), 389–397 (2003).

    Article  PubMed  CAS  Google Scholar 

  33. O. N. Koc, S. L. Gerson, B. W. Cooper, S. M. Dyhouse, S. E. Haynesworth, A. I. Caplan and H. M. Lazarus, Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy, J Clin Oncol 18(2), 307–316 (2000).

    PubMed  CAS  Google Scholar 

  34. O. N. Koc and H. M. Lazarus, Mesenchymal stem cells: Heading into the clinic, Bone Marrow Transplant 27(3), 235–239 (2001).

    Article  PubMed  CAS  Google Scholar 

  35. P. Mandalfino, G. Rice, A. Smith, J. L. Klein, L. Rystedt and G. C. Ebers, Bone marrow transplantation in multiple sclerosis, J Neurol 247(9), 691–695 (2000).

    Article  PubMed  CAS  Google Scholar 

  36. O. Y. Bang, J. S. Lee, P. H. Lee and G. Lee, Autologous mesenchymal stem cell transplantation in stroke patients, Ann Neurol 57(6), 874–882 (2005).

    Article  PubMed  Google Scholar 

  37. L. Wang, Y. Li, J. Chen, S. C. Gautam, Z. Zhang, M. Lu and M. Chopp, Ischemic cerebral tissue and mcp-1 enhance rat bone marrow stromal cell migration in interface culture, Exp Hematol 30(7), 831–836 (2002).

    Article  PubMed  CAS  Google Scholar 

  38. L. Wang, Y. Li, X. Chen, J. Chen, S. C. Gautam, Y. Xu and M. Chopp, Mcp-1, mip-1, il-8 and ischemic cerebral tissue enhance human bone marrow stromal cell migration in interface culture, Hematology 7(2), 113–117 (2002).

    Article  PubMed  CAS  Google Scholar 

  39. A. Mahmood, D. Lu and M. Chopp, Intravenous administration of marrow stromal cells (MSCs) increases the expression of growth factors in rat brain after traumatic brain injury, J Neurotrauma 21(1), 33–39 (2004).

    Article  PubMed  Google Scholar 

  40. J. Zhang, Y. Li, J. Chen, M. Yang, M. Katakowski, M. Lu and M. Chopp, Expression of insulin-like growth factor 1 and receptor in ischemic rats treated with human marrow stromal cells, Brain Res 1030(1), 19–27 (2004).

    Article  PubMed  CAS  Google Scholar 

  41. X. Chen, Y. Li, L. Wang, M. Katakowski, L. Zhang, J. Chen, Y. Xu, S. C. Gautam and M. Chopp, Ischemic rat brain extracts induce human marrow stromal cell growth factor production, Neuropathology 22(4), 275–279 (2002).

    Article  PubMed  Google Scholar 

  42. X. Chen, M. Katakowski, Y. Li, D. Lu, L. Wang, L. Zhang, J. Chen, Y. Xu, S. Gautam, A. Mahmood and M. Chopp, Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: Growth factor production, J Neurosci Res 69(5), 687–691 (2002).

    Article  PubMed  CAS  Google Scholar 

  43. Y. Tamada, C. Fukiage, D. L. Boyle, M. Azuma and T. R. Shearer, Involvement of cysteine proteases in bfgf-induced angiogenesis in guinea pig and rat cornea, J Ocul Pharmacol Ther 16(3), 271–283 (2000).

    PubMed  CAS  Google Scholar 

  44. K. Hamano, T. S. Li, T. Kobayashi, S. Kobayashi, M. Matsuzaki and K. Esato, Angiogenesis induced by the implantation of self-bone marrow cells: A new material for therapeutic angiogenesis, Cell Transplant 9(3), 439–443 (2000).

    PubMed  CAS  Google Scholar 

  45. G. A. Fournier, G. A. Lutty, S. Watt, A. Fenselau and A. Patz, A corneal micropocket assay for angiogenesis in the rat eye, Invest Ophthalmol Vis Sci 21(2), 351–354 (1981).

    PubMed  CAS  Google Scholar 

  46. M. Chopp and Y. Li, Treatment of neural injury with marrow stromal cells, Lancet Neurol 1(2), 92–100 (2002).

    Article  PubMed  Google Scholar 

  47. Z. G. Zhang, L. Zhang, W. Tsang, H. Soltanian-Zadeh, D. Morris, R. Zhang, A. Goussev, C. Powers, T. Yeich and M. Chopp, Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia, J Cereb Blood Flow Metab 22(4), 379–392 (2002).

    Article  PubMed  CAS  Google Scholar 

  48. Z. G. Zhang, W. Tsang, L. Zhang, C. Powers and M. Chopp, Up-regulation of neuropilin-1 in neovasculature after focal cerebral ischemia in the adult rat, J Cereb Blood Flow Metab 21(5), 541–549 (2001).

    Article  PubMed  Google Scholar 

  49. S. Cohen-Cory, The developing synapse: Construction and modulation of synaptic structures and circuits, Science 298(5594), 770–776 (2002).

    Article  PubMed  CAS  Google Scholar 

  50. T. Theodosis and D. A. Poulain, Contribution of astrocytes to activity-dependent structural plasticity in the adult brain, pp. 175–182 Kluwer Academic/Plenum Publishers, New York (1999).

    Google Scholar 

  51. R. D. Fields and B. Stevens-Graham, New insights into neuron-glia communication, Science 298(5593), 556–562 (2002).

    Article  PubMed  CAS  Google Scholar 

  52. J. Fok-Seang, N. A. DiProspero, S. Meiners, E. Muir and J. W. Fawcett, Cytokine-induced changes in the ability of astrocytes to support migration of oligodendrocyte precursors and axon growth, Eur J Neurosci 10(7), 2400–2415 (1998).

    Article  PubMed  CAS  Google Scholar 

  53. N. G. Gourmala, S. Limonta, D. Bochelen, A. Sauter and H. W. Boddeke, Localization of macrophage inflammatory protein: Macrophage inflammatory protein-1 expression in rat brain after peripheral administration of lipopolysaccharide and focal cerebral ischemia, Neuroscience 88(4), 1255–1266 (1999).

    Article  PubMed  CAS  Google Scholar 

  54. V. Darsalia, U. Heldmann, O. Lindvall and Z. Kokaia, Stroke-induced neurogenesis in aged brain, Stroke 36(8): 1790–1795 (2005).

    Article  PubMed  Google Scholar 

  55. R. J. Lichtenwalner and J. M. Parent, Adult neurogenesis and the ischemic forebrain, J Cereb Blood Flow Metab Advance online publication 15 June (2005).

    Google Scholar 

  56. P. M. Rossini and G. Dal Forno, Neuronal post-stroke plasticity in the adult, Restor Neurol Neurosci 22(3–5), 193–206 (2004).

    Google Scholar 

  57. S. B. Frost, S. Barbay, K. M. Friel, E. J. Plautz and R. J. Nudo, Reorganization of remote cortical regions after ischemic brain injury: A potential substrate for stroke recovery, J Neurophysiol 89(6), 3205–3214 (2003).

    Article  PubMed  CAS  Google Scholar 

  58. Y. Li, J. Chen and M. Chopp, Cell proliferation and differentiation from ependymal, subependymal and choroid plexus cells in response to stroke in rats, J Neurol Sci 193(2), 137–146 (2002).

    Article  PubMed  Google Scholar 

  59. R. L. Zhang, Z. G. Zhang, L. Zhang and M. Chopp, Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia, Neuroscience 105(1), 33–41 (2001).

    Article  PubMed  CAS  Google Scholar 

  60. R. L. Zhang, L. Zhang, Z. G. Zhang, D. Morris, Q. Jiang, L. Wang, L. J. Zhang and M. Chopp, Migration and differentiation of adult rat subventricular zone progenitor cells transplanted into the adult rat striatum, Neuroscience 116(2), 373–382 (2003).

    Article  PubMed  CAS  Google Scholar 

  61. R. Zhang, Z. Zhang, C. Zhang, L. Zhang, A. Robin, Y. Wang, M. Lu and M. Chopp, Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal differentiation in the adult rat, J Neurosci 24(25), 5810–5815 (2004).

    Article  PubMed  CAS  Google Scholar 

  62. S. C. Cramer and M. Chopp, Recovery recapitulates ontogeny, Trends Neurosci 23(6), 265–271 (2000).

    Article  PubMed  CAS  Google Scholar 

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Chopp, M., Li, Y., Shen, L. (2008). Transplantation of Bone Marrow Stromal Cells for the Treatment of Stroke. In: Savitz, S.I., Rosenbaum, D.M. (eds) Stroke Recovery with Cellular Therapies. Current Clinical Neurology. Humana Press. https://doi.org/10.1007/978-1-60327-057-1_2

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