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TACI Signaling and Its Role in Immunity

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BLyS Ligands and Receptors

Part of the book series: Contemporary Immunology ((CONTIM))

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Abstract

Transmembrane activator and CAML interactor (TACI) was initially described 10 years ago. Since that time, it has been increasingly recognized as an important regulator of immunity in both mice and humans. Although much has been learned about its signaling and physiological functions, its complexity in terms of ligand binding, cell-type-specific effects, as well as potential roles in human disease dictates that much work remains to be done in this area. In this chapter, the basic signaling and physiologic role of TACI will be discussed.

Financial Disclosure: The author is listed as an inventor on three patents related to the TACI gene and protein held by St. Jude Children’s Research Hospital and licensed to Zymogenetics.

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Authors and Affiliations

  1. Departments of Immunology and Pediatric and Adolescent Medicine, Mayo Clinic, 55905, Rochester, MN, USA

    Richard J. Bram

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  1. Richard J. Bram
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Editors and Affiliations

  1. School of Medicine, University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, 19104-6082, U.S.A.

    Michael P. Cancro

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Bram, R.J. (2009). TACI Signaling and Its Role in Immunity. In: Cancro, M. (eds) BLyS Ligands and Receptors. Contemporary Immunology. Humana Press. https://doi.org/10.1007/978-1-60327-013-7_6

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