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Imaging Adrenal Dysfunction

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References

  1. Isidori AM, Kaltsas GA, Pozza C, Frajese V, Newell-Price J, Reznek RH et al. (2006) The ectopic adrenocorticotropin syndrome: clinical features, diagnosis, management, and long-term follow-up. J Clin Endocrinol Metab 91(2):371–377

    Article  PubMed  CAS  Google Scholar 

  2. Sohaib SA, Hanson JA, Newell-Price JD, Trainer PJ, Monson JP, Grossman AB et al. (1999) CT appearance of the adrenal glands in adrenocorticotrophic hormone-dependent Cushing's syndrome. AJR Am J Roentgenol 172(4):997–1002

    PubMed  CAS  Google Scholar 

  3. Doppman JL, Miller DL, Dwyer AJ, Loughlin T, Nieman L, Cutler GB, Chrousos GP, Oldfield E, Loriaux DL (1988) Macronodular adrenal hyperplasia in Cushing disease. Radiology 166(2):347–352

    PubMed  CAS  Google Scholar 

  4. Vincent JM, Trainer PJ, Reznek RH, Marcus AJ, Dacie JE, Armstrong P, Besser GM (1993) The radiological investigation of occult ectopic ACTH-dependent Cushing's syndrome. Clin Radiol 48(1):11–17

    Article  PubMed  CAS  Google Scholar 

  5. Ilias I, Torpy DJ, Pacak K, Mullen N, Wesley RA, Nieman LK (2005) Cushing's syndrome due to ectopic corticotropin secretion: twenty years' experience at the National Institutes of Health. J Clin Endocrinol Metab 90(8):4955–4962

    Article  PubMed  CAS  Google Scholar 

  6. Pacak K, Ilias I, Chen CC, Carrasquillo JA, Whatley M, Nieman LK (2004) The role of [(18)F]-fluorodeoxyglucose positron emission tomography and [(111)In]-diethylenetriaminepentaacetate-D-Phe-pentetreotide scintigraphy in the localization of ectopic adrenocorticotropin-secreting tumors causing Cushing's syndrome. J Clin Endocrinol Metab 89(5):2214–2221

    Article  PubMed  CAS  Google Scholar 

  7. Boscaro M, Fallo F, Barzon L, Daniele O, Sonino N (1995) Adrenocortical carcinoma: epidemiology and natural history. Minerva Endocrinol 20(1):89–94

    PubMed  CAS  Google Scholar 

  8. Rockall AG, Babar SA, Sohaib SA, Isidori AM, Diaz-Cano S, Monson JP, Grossman AB, Reznek RH (2004) CT and MR imaging of the adrenal glands in ACTH-independent Cushing’s syndrome. Radiographics 24(2):435–452

    Article  PubMed  Google Scholar 

  9. Dinneen SF, Carney JA, Carpenter PC, Grant CS, Young WF Jr (1995) Acth-independent Cushing's syndrome: bilateral cortisol-producing adrenal adenomas. Endocr Pract 1(2):77–81

    PubMed  CAS  Google Scholar 

  10. Tung SC, Wang PW, Huang TL, Lee WC, Chen WJ (2004) Bilateral adrenocortical adenomas causing ACTH-independent Cushing's syndrome at different periods: a case report and discussion of corticosteroid replacement therapy following bilateral adrenalectomy. J Endocrinol Invest 27(4):375–379

    Google Scholar 

  11. Nomura K, Saito H, Aiba M, Iihara M, Obara T, Takano K (2003) Cushing's syndrome due to bilateral adrenocortical adenomas with unique histological features. Endocr J 50(2):155–162

    Article  PubMed  Google Scholar 

  12. Ayala AR, Basaria S, Udelsman R, Westra WH, Wand GS (2000) Corticotropin-independent Cushing's syndrome caused by an ectopic adrenal adenoma. J Clin Endocrinol Metab 85(8):2903–2906

    Article  PubMed  CAS  Google Scholar 

  13. Szolar DH, Korobkin M, Reittner P, Berghold A, Bauernhofer T, Trummer H, Schoellnast H, Preidler KW, Samonigg H (2005) Adrenocortical carcinomas and adrenal pheochromocytomas: mass and enhancement loss evaluation at delayed contrast-enhanced CT. Radiology 234(2):479–485

    Article  PubMed  Google Scholar 

  14. Slattery JM, Blake MA, Kalra MK, Misdraji J, Sweeney AT, Copeland PM, Mueller PR, Boland GW (2006) Adrenocortical carcinoma: contrast washout characteristics on CT. AJR Am J Roentgenol 187(1):W21–W24

    Article  PubMed  Google Scholar 

  15. Doppman JL, Travis WD, Nieman L, Miller DL, Chrousos GP, Gomez MT, Cutler GB Jr, Loriaux DL, Norton JA (1989) Cushing syndrome due to primary pigmented nodular adrenocortical disease: findings at CT and MR imaging. Radiology 172(2):415–420

    PubMed  CAS  Google Scholar 

  16. Doppman JL, Chrousos GP, Papanicolaou DA, Stratakis CA, Alexander HR, Nieman LK (2000) Adrenocorticotropin-independent macronodular adrenal hyperplasia: an uncommon cause of primary adrenal hypercortisolism. Radiology 216(3):797–802

    PubMed  CAS  Google Scholar 

  17. Lieberman SA, Eccleshall TR, Feldman D (1994) ACTH-independent massive bilateral adrenal disease (AIMBAD): a subtype of Cushing's syndrome with major diagnostic and therapeutic implications. Eur J Endocrinol 131(1):67–73

    Article  PubMed  CAS  Google Scholar 

  18. Lingam RK, Sohaib SA, Rockall AG, Isidori AM, Chew S, Monson JP et al. (2004) Diagnostic performance of CT versus MR in detecting aldosterone-producing adenoma in primary hyperaldosteronism (Conn's syndrome). Eur Radiol 14(10):1787–1792

    Article  PubMed  CAS  Google Scholar 

  19. Ikeda DM, Francis IR, Glazer GM, Amendola MA, Gross MD, Aisen AM (1989) The detection of adrenal tumors and hyperplasia in patients with primary aldosteronism: comparison of scintigraphy, CT, and MR imaging. AJR Am J Roentgenol 153(2):301–306

    PubMed  CAS  Google Scholar 

  20. Geisinger MA, Zelch MG, Bravo EL, Risius BF, O'Donovan PB, Borkowski GP (1983) Primary hyperaldosteronism: comparison of CT, adrenal venography, and venous sampling. AJR Am J Roentgenol 141(2):299–302

    PubMed  CAS  Google Scholar 

  21. Lingam RK, Sohaib SA, Vlahos I, Rockall AG, Isidori AM, Monson JP et al. (2003) CT of primary hyperaldosteronism (Conn's syndrome): the value of measuring the adrenal gland. AJR Am J Roentgenol 181(3):843–849

    PubMed  CAS  Google Scholar 

  22. Sohaib SA, Peppercorn PD, Allan C, Monson JP, Grossman AB, Besser GM et al. (2000) Primary hyperaldosteronism (Conn syndrome): MR imaging findings. Radiology 214(2):527–531

    PubMed  CAS  Google Scholar 

  23. Harvey A, Kline G, Pasieka JL (2006) Adrenal venous sampling in primary hyperaldosteronism: comparison of radiographic with biochemical success and the clinical decision-making with “less than ideal” testing. Surgery 140(6):847–853; discussion 853–855

    Article  PubMed  Google Scholar 

  24. Espiner EA, Ross DG, Yandle TG, Richards AM, Hunt PJ (2003) Predicting surgically remedial primary aldosteronism: role of adrenal scanning, posture testing, and adrenal vein sampling. J Clin Endocrinol Metab 88(8):3637–3644

    Article  PubMed  CAS  Google Scholar 

  25. Young WF, Stanson AW, Thompson GB, Grant CS, Farley DR, van Heerden JA (2004) Role for adrenal venous sampling in primary aldosteronism. Surgery 136(6):1227–1235

    Article  PubMed  Google Scholar 

  26. Tan YY, Ogilvie JB, Triponez F, Caron NR, Kebebew EK, Clark OH et al. (2006) Selective use of adrenal venous sampling in the lateralization of aldosterone-producing adenomas. World J Surg 30(5):879–885; discussion 886–887

    Article  PubMed  Google Scholar 

  27. Nocaudie-Calzada M, Huglo D, Lambert M, Ernst O, Proye C, Wemeau JL et al. (1999) Efficacy of iodine-131 6-beta-methyl-iodo-19-norcholesterol scintigraphy and computed tomography in patients with primary aldosteronism. Eur J Nucl Med 26(10):1326–1332

    PubMed  CAS  Google Scholar 

  28. Maurea S, Klain M, Caraco C, Ziviello M, Salvatore M (2002) Diagnostic accuracy of radionuclide imaging using 131I nor-cholesterol or meta-iodobenzylguanidine in patients with hypersecreting or non-hypersecreting adrenal tumours. Nucl Med Commun 23(10):951–960

    Article  PubMed  CAS  Google Scholar 

  29. Lumachi F, Marzola MC, Zucchetta P, Tregnaghi A, Cecchin D, Favia G et al. (2003) Non-invasive adrenal imaging in primary aldosteronism. Sensitivity and positive predictive value of radiocholesterol scintigraphy, CT scan and MRI. Nucl Med Commun 24(6):683–688

    Article  PubMed  CAS  Google Scholar 

  30. Kaltsas GA, Mukherjee JJ, Kola B, Isidori AM, Hanson JA, Dacie JE, Reznek R, Monson JP, Grossman AB (2003) Is ovarian and adrenal venous catheterization and sampling helpful in the investigation of hyperandrogenic women? Clin Endocrinol (Oxf) 59(1):34–43

    Article  CAS  Google Scholar 

  31. Harinarayana CV, Renu G, Ammini AC, Khurana ML, Ved P, Karmarkar MG, Ahuja MM, Berry M (1991) Computed tomography in untreated congenital adrenal hyperplasia. Pediatr Radiol 21(2):103–105

    Article  PubMed  CAS  Google Scholar 

  32. Falke TH, van Seters AP, Schaberg A, Moolenaar AJ (1986) Computed tomography in untreated adults with virilizing congenital adrenal cortical hyperplasia. Clin Radiol 37(2):155–160

    Article  PubMed  CAS  Google Scholar 

  33. Bhatia V, Shukla R, Mishra SK, Gupta RK (1993) Adrenal tumor complicating untreated 21-hydroxylase deficiency in a 5 1/2-year-old boy. Am J Dis Child 147(12):1321–1323

    PubMed  CAS  Google Scholar 

  34. Bonfig W, Bittmann I, Bechtold S, Kammer B, Noelle V, Arleth S et al. (2003) Virilising adrenocortical tumours in children. Eur J Pediatr 162(9):623–628

    Article  PubMed  Google Scholar 

  35. Allolio B, Fassnacht M (2006) Clinical review: adrenocortical carcinoma: clinical update. J Clin Endocrinol Metab 91(6):2027–2037

    Article  PubMed  CAS  Google Scholar 

  36. DeLellis RA, Wolfe HJ, Gagel RF, Feldman ZT, Miller HH, Gang DL, Reichlin S (1976) Adrenal medullary hyperplasia. A morphometric analysis in patients with familial medullary thyroid carcinoma. Am J Pathol 83(1):177–196

    PubMed  CAS  Google Scholar 

  37. Lack EE (1997) Tumours of the adrenal gland and extra-adrenal paraganglia. Third series ed. Armed Forces Institute of Pathology, Washington DC

    Google Scholar 

  38. Chen M, Lu G, Zhang Q (2002) Adrenal cortical and medullar hyperplasia–a retrospective analysis of 6 cases. J Huazhong Univ Sci Technolog Med Sci 22(4):367–368, 374

    Article  PubMed  Google Scholar 

  39. Rudy FR, Bates RD, Cimorelli AJ, Hill GS, Engelman K (1980) Adrenal medullary hyperplasia: a clinicopathologic study of four cases. Hum Pathol 11(6):650–657

    Article  PubMed  CAS  Google Scholar 

  40. Yung BC, Loke TK, Tse TW, Tsang MW, Chan JC (2000) Sporadic bilateral adrenal medullary hyperplasia: apparent false positive MIBG scan and expected MRI findings. Eur J Radiol 36(1):28–31

    Article  PubMed  CAS  Google Scholar 

  41. Qupty G, Ishay A, Peretz H, Dharan M, Kaufman N, Luboshitzky R (1997) Pheochromocytoma due to unilateral adrenal medullary hyperplasia. Clin Endocrinol (Oxf) 47(5):613–617

    Article  CAS  Google Scholar 

  42. Carney JA, Sizemore GW, Tyce GM (1975) Bilateral adrenal medullary hyperplasia in multiple endocrine neoplasia, type 2: the precursor of bilateral pheochromocytoma. Mayo Clin Proc 50(1):3–10

    PubMed  CAS  Google Scholar 

  43. Jansson S, Khorram-Manesh A, Nilsson O, Kolby L, Tisell LE, Wangberg B, Ahlman H (2006) Treatment of bilateral pheochromocytoma and adrenal medullary hyperplasia. Ann N Y Acad Sci 1073:429–435

    Article  PubMed  Google Scholar 

  44. Kushner BH (2004) Neuroblastoma: a disease requiring a multitude of imaging studies. J Nucl Med 45(7):1172–1188

    PubMed  Google Scholar 

  45. Pfluger T, Schmied C, Porn U, Leinsinger G, Vollmar C, Dresel S, Schmid I, Hahn K (2003) Integrated imaging using MRI and 123I metaiodobenzylguanidine scintigraphy to improve sensitivity and specificity in the diagnosis of pediatric neuroblastoma. AJR Am J Roentgenol 181(4):1115–1124

    PubMed  Google Scholar 

  46. Ilias I, Shulkin B, Pacak K (2005) New functional imaging modalities for chromaffin tumors, neuroblastomas and ganglioneuromas. Trends Endocrinol Metab 16(2):66–72

    Article  PubMed  CAS  Google Scholar 

  47. Mehta N, Tripathi RP, Popli MB, Nijhawan VS (1997) Bilateral intraabdominal ganglioneuroblastoma in an adult. Br J Radiol 70:96–98

    PubMed  CAS  Google Scholar 

  48. Lovas K, Husebye ES (2002) High prevalence and increasing incidence of Addison's disease in western Norway. Clin Endocrinol (Oxf) 56(6):787–791

    Article  Google Scholar 

  49. Falorni A, Laureti S, De Bellis A, Zanchetta R, Tiberti C, Arnaldi G et al. (2004) SIE Addison Study Group. Italian Addison network study: update of diagnostic criteria for the etiological classification of primary adrenal insufficiency. J Clin Endocrinol Metab 89(4):1598–1604

    Article  PubMed  CAS  Google Scholar 

  50. Chin R (1991) Adrenal crisis. Crit Care Clin 7:23–42

    PubMed  CAS  Google Scholar 

  51. Itoh K, Yamashita K, Satoh Y, Sawada H (1988) MR imaging of bilateral adrenal hemorrhage. J Comput Assist Tomogr 12(6):1054–1056

    Article  PubMed  CAS  Google Scholar 

  52. Kawashima A, Sandler CM, Ernst RD, Takahashi N, Roubidoux MA, Goldman SM, Fishman EK, Dunnick NR (1999) Imaging of nontraumatic hemorrhage of the adrenal gland. Radiographics 19(4):949–963

    PubMed  CAS  Google Scholar 

  53. Yang ZG, Guo YK, Li Y, Min PQ, Yu JQ, Ma ES (2006) Differentiation between tuberculosis and primary tumors in the adrenal gland: evaluation with contrast-enhanced CT. Eur Radiol 16(9):2031–2036. Epub 2006 Jan 25

    Article  PubMed  Google Scholar 

  54. Betterle C, Dal Pra C, Mantero F, Zanchetta R (2002) Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocr Rev 23(3):327–364. Review. Erratum in: Endocr Rev 23(4):579

    Article  PubMed  CAS  Google Scholar 

  55. Trainer PJ, Besser GM (2002) Addison’s Disease. In: Besser GM, Thorner MO (eds) Clinical endocrinology, 3rd edn, Mosby, London, pp 203–212

    Google Scholar 

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Sahdev, A., Reznek, R.H. (2009). Imaging Adrenal Dysfunction. In: Blake, M., Boland, G. (eds) Adrenal Imaging. Contemporary Medical Imaging. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59745-560-2_6

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