Abstract
The Human Genome Project and the emergence of accompanying technology are beginning to transform the drug discovery process. Sequence and structure databases are offering new avenues for the identification of novel genes and drug targets. This communication reviews how bioinformatics and chemogenomics are used for new gene identification, selection of genes or proteins that may be potential drug targets, and the screening of libraries, both in vitro and in silico, for designation of new lead drug compounds.
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References
Dougherty, J. D. and Geschwind, D. H. (2002) Subtraction-coupled custom microarray analysis for gene discovery and gene expression studies in the CNS. Chem. Senses 27(3), 293–298.
Friedberg, I. and Godzik, A. (2005) Connecting the protein structure universe by using sparse recurring fragments. Structure 13(8), 1213–1224.
Hann, M. M. and Oprea, T. I. (2004) Pursuing the leadlikeness concept in pharmaceutical research. Curr. Opin. Chem. Biol. 8, 255–263.
Scherf, U., Ross, D. T., Waltham, M., et al. (2000) A gene expression database for the molecular pharmacology of cancer. Nature Genet. 24(3), 236–244.
Ross, D. T., Scherf, U., Eisen, M. B., et al. (2000) Systematic variation in gene expression patterns in human cancer cell lines. Nat. Genet. 24(3), 227–235.
Dai, Z., Barbacioru, C., Huang, Y., and Sadee, W. (2006) Prediction of anticancer drug potency from expression of genes involved in growth factor signaling. Pharm. Res. 23(2), 336–349.
Schneider, G. and Fechner, U. (2005) Computer-based de novo design of drug-like molecules. Nat. Rev. Drug Discov. 4(8), 649–663.
Ortiz, A. R., Gomez-Puertas, P., Leo-Macias, A., et al. (2006) Computational approaches to model ligand selectivity in drug design. Curr. Top Med. Chem. 6(1), 41–55.
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© 2008 Humana Press Inc., Totowa, NJ
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Wu-Pong, S., Shiang, R. (2008). The Use of Bioinformatics and Chemogenomics in Drug Discovery. In: Wu-Pong, S., Rojanasakul, Y. (eds) Biopharmaceutical Drug Design and Development. Humana Press. https://doi.org/10.1007/978-1-59745-532-9_3
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DOI: https://doi.org/10.1007/978-1-59745-532-9_3
Publisher Name: Humana Press
Print ISBN: 978-1-58829-716-7
Online ISBN: 978-1-59745-532-9
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