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Dissecting Transcriptional Control Networks

  • Vijayalakshmi H. Nagaraj
  • Anirvan M. Sengupta

Abstract

Reconstructing how transcriptional networks function involves figuring out which promoters are affected by which transcription factors. Searching for functional regulatory sites bound by particular transcription factors in a genome is therefore of great importance. The chapter discusses efforts at building classifiers that separate promoters targeted by particular transcription factors from those that are not. We start with simple sequence classifiers based on Support Vector Machines and go on to discuss how to integrate different kind of data into the analysis.

Key Words

Transcription regulatory elements motifs support vector machines probabilistic models DNA sequence evolution 

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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Vijayalakshmi H. Nagaraj
    • 1
  • Anirvan M. Sengupta
    • 1
  1. 1.BioMaPS InstituteRutgers University, The State University of New JerseyPiscatawayUSA

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