Kinetics of Dimension-Restricted Conditions

  • Noriko Hiroi
  • Akira Funahashi


The intracellular environment is crowded with skeletal proteins, organelle membranes, ribosomes, and so on. When molecular movement is restricted by such environments, some biochemical reaction processes cannot be represented by classical models, which assume that reactions occur in simple Newtonian fluids. Dimension-restricted reaction kinetics (DRRK) modeling is a method that can represent dimension-restricted reactions. We introduce the methods of DRRK in each case of reaction type. DRRK has another advantage in that it can be quantitatively evaluated by biochemical experiments. We also introduce the procedure of applying it for experimental results. This modeling method may provide the basis for in vivo-oriented modeling.

Key Words

Fractal kinetics percolation theory 


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Copyright information

© Humana Press Inc. 2007

Authors and Affiliations

  • Noriko Hiroi
    • 1
  • Akira Funahashi
    • 1
  1. 1.ERATO-SORST Kitano Symbiotic Systems ProjectJapan Science and Technology AgencyTokyoJapan

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