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Age-Related Changes and/or Diseases in the Human Retina

  • Nicola Pescosolido
  • Panagiotis Karavitis
Part of the Aging Medicine book series (AGME)

Abstract

As people grow older, changes in the retina occur as part of the natural course of aging. Additional changes in the retina come from pathological causes, for which an ophthalmology specialist may be asked to evaluate and treat. Often patients will present to an eye doctor with complaints of worsening vision or visual distortions that cannot be accounted for by media opacity (cataract) or refractive error. A solid working knowledge of the normal age-related changes of the retina, as well as a firm understanding of clinically relevant age-related pathology, will help any eye physician manage the aging patient population. The aim of this study is not only to fully understand the senile involution of retinal structures that allows us to observe the wonders of the world, but also to keep these structures intact for as long as possible. An increasing number of elderly give a good cause for investigation of age-related changes and/or diseases in the human retina. This chapter describes the major age-related changes and diseases of the human retina in aged people. The first part of the chapter deals with common lesions in the senile retina, while the second part describes the major diseases of the senile retina.

Keywords

Retina aging retina age-related changes retina diseases senile retina retina involution human retina 

References

  1. 1.
    Owsley C, Jackson GR, Cideciyan AV, Huang Y, Fine SL, Ho AC, Maguire MG, Lolley V, Jacobson SG (2000) Psychophysical evidence for rod vulnerability in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 41:267–273PubMedGoogle Scholar
  2. 2.
    Armstrong D (1984) Free radical involvement in the formation of lipo-pigments. In: Armstrong D (ed) Free Radicals in Molecular Biology, Aging and Disease. Raven Press, New York, p 137–182Google Scholar
  3. 3.
    Brizee KR, and Ordy JM (1981) Cellular features, regional accumulation, and prospects of modification of age pigments in mammals. In: Sohal RS (ed) Ageing Pigments Elsevier/North — Holland Biomedical Press, Amsterdam, p 176–181Google Scholar
  4. 4.
    Dykens JA (1999) Free radicals and mitochondria dysfunction in excyto-toxicity and neurodegenerative disease. In: Koliatos VE and Rantan RR (eds) Cell Death and Diseases of the Nervous System, Humana Press, Totowa, P 45–68Google Scholar
  5. 5.
    Handelman GJ and Dratz EA (1986) The role of antioxidants in the retina and retinal pigment epithelium and the nature of pro-oxidant induced damage. Adv. Free Radicals. Biol. Med. 2:1:89Google Scholar
  6. 6.
    Cavallotti C, Artico M, Pescosolido N, Feher J (2004) Age-related Changes in human retina. Can. J Ophthalmol. 39:61–68PubMedGoogle Scholar
  7. 7.
    Foulds WS (1980) Factors influencing visual recovery in retinal detachment surgery. Trans. Ophthalmol. Soc.U.K.100:72–77PubMedGoogle Scholar
  8. 8.
    Straatsma BR, Foos RY, Feman SS (1980) Degenerative diseases of the peripheral retina. In: Duane TD (ed) Clinical Ophthalmology. Harper & Row, Philadelphia, p 1–27Google Scholar
  9. 9.
    O'Malley PF, and Allen RA (1967) Peripheral cystoid degeneration of the retina. Incidence and distribution in 1,000 autopsy eyes. Arch. Ophthalmol. 77:769–776PubMedGoogle Scholar
  10. 10.
    Curcio CA, Millican CL, Allen KA, Kalina R.E. (1993) Aging of the human photoreceptor mosaic: Evidence for selective vulnerability of rods in central retina. Invest. Ophthalmol. Vis. Sci. 34:3278–3296PubMedGoogle Scholar
  11. 11.
    Marshall J (1987) The ageing retina: physiology and pathology. Eye. 1: 282–295PubMedGoogle Scholar
  12. 12.
    De Laey JJ (1988) Ophtalmologie geriatrique. In: Oosterhosch (ed) Traité de Geriatrie,Sociéte Scientifique de Medicine Generale, Bruxelles, p 263–488Google Scholar
  13. 13.
    Foos RY (1970) Senile Retinoschisis: relationship to cystoid degeneration. Trans. Am. Acad. Ophthalmol. 68:329–403Google Scholar
  14. 14.
    Byer NE (1989) Long-term natural history of lattace degeneration of the retina. Ophthalmology. 96:1396–1402PubMedGoogle Scholar

Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Nicola Pescosolido
    • 1
  • Panagiotis Karavitis
    • 2
    • 2
  1. 1.Department of Aging SciencesUniversity of Rome “La Sapienza,”RomeItaly
  2. 2.Senior Researcher Section of Ophthalmology, OphthalmologyUniversity of AthensAthensGreece

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