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Age-Related Changes of the Eyelid

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Age-Related Changes of the Human Eye

Part of the book series: Aging Medicine ((AGME))

Abstract

Changes of the orbicular muscle and its connective tissue play a central role in the aging of the eyelid. Age-related changes of orbicular muscle comprise a decrease of muscular fibers and a disorganization of banding structures (appearance of nemaline bodies, Z-line streaming, cytoplasmic bodies, and Z-line doubling). Mitochondria, particularly in the subsarcolemmal area, showed either a decrease in number and loss of cristae, or enlargement and proliferation of cristae. In combination with both alterations, intramitochondrial crystal formation and altered succinyl-dehydrogenase activity were also a frequent observation. Tubular aggregates originated from the sarcoplasmic reticulum and various sarcoplasmic inclusions were also observed. Intramuscular connective tissue density increased with age, and it was associated with increased glycation of collagen fibers. Neither of these alterations are considered specific for aging, but their particular combination may be responsible for the development of well-known, age-related changes and diseases of the eyelid. In addition, these data may give further information to the pathology of sarcopenia—a devastating age-related muscle disease.

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Author information

Authors and Affiliations

  1. Nutripharma Hungaria Ltd., Budapest, Hungary

    Janos Feher MD, PhD

  2. School of Sport Medicine, Semmelweis University, Budapest, Hungary

    Zsolt Olah BSc

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  1. Janos Feher MD, PhD
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  2. Zsolt Olah BSc
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Editors and Affiliations

  1. Department of Cardiovascular, Respiratory and Morphological Sciences, University of Rome, La Sapienza, Rome, Italy

    Carlo A. P. Cavallotti MD, PhD

  2. Department of Ophthalmology, University of Rome, Tor Vergata, Rome, Italy

    Luciano Cerulli MD, PhD

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

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Feher, J., Olah, Z. (2008). Age-Related Changes of the Eyelid. In: Cavallotti, C.A.P., Cerulli, L. (eds) Age-Related Changes of the Human Eye. Aging Medicine. Humana Press. https://doi.org/10.1007/978-1-59745-507-7_2

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  • DOI: https://doi.org/10.1007/978-1-59745-507-7_2

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-934115-55-8

  • Online ISBN: 978-1-59745-507-7

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