The Role of Potassium Channels in the Regulation of Neurotransmitter Release

  • Laurence O. TrussellEmail author
  • Michael T. Roberts
Part of the Contemporary Neuroscience book series (CNEURO)


Neurotransmitter release is critically dependent on the duration of the presynaptic action potential. A variety of K+ channels play key roles in determining spike width. Moreover, K+ channels control how readily terminals can spike, and also suppress aberrant firing. Finally, K+ channels, through their control of the presynaptic resting potential, may impact presynaptic calcium levels and the spontaneous and evoked release of transmitter.


Axon exocytosis transmitter release synapse potassium channel 



We wish to thank Drs. Paul Brehm, Hai Huang, and Sid Kuo for comments on the manuscript. This work was supported by National Institutes of Health (NIH) grants NS28901 and DC04450.


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© Humana Press, a part of Springer Science + Business Media, LLC 2008

Authors and Affiliations

  1. 1.Oregon Hearing Research Center / Vollum InstitutePortlandUSA
  2. 2.Oregon Hearing Research Center/Vollum InstituteOregon Health and Science UniversityPortlandUSA

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