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Unrelated Donor Transplants

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Allogeneic Stem Cell Transplantation

Part of the book series: Contemporary Hematology ((CH))

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Abstract

Unrelated donor (UD) hemopoietic stem cell transplants (HSCT)are being increasingly used, as shown by the annual survey of the European group for Blood and Marrow Transplantation (EBMT): in Europe the number of recorded UD transplants was 752 in 1995 and it was 3617 after 10 years in 2005 (Fig. 19.1), suggesting that most transplant Centres are becoming more confident with the procedure, and that clinical results justify the investment in clinical care and research.Several factors have contributed to this very significant increase in activity: improved human leukocyte antigen (HLA) typing technology, better matching criteria, increased size of the world wide donor pool and improved transplant programs. We will briefly outline each of these different factors. We will not discuss in this chapter transplants from unrelated cord blood, since this is a procedure with specific characteristics; we will restrict the discussion to transplants from unrelated donors who are filed in the National Donor Registries and then in the World Wide File.

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Abbreviations

UD:

unrelated donors

EBMT:

European group for Blood and Marrow Transplantation

HSCT:

hemopoietic stem cell transplants

HLA:

human leukocyte antigen

BMT:

bone marrow transplantation

m-HA:

minor histocompatibility antigens

NK:

natural killer cells

NMDP:

National Marrow Donor Program

JMDP:

Japanese marrow donor program

BMDWW:

Bone Marrow Donors World Wide

HSC:

hemopoietic stem cells

FACT:

Foundation for the Accreditation of Cell Therapy

ISCT:

Internation Society for Cell Therapy

JACIE:

Joint Accrediation Committee of the IST and EBMT

EUSTITE:

European Union Standards and Training in the Inspection of Tissue Establishements.

WMDA:

World Marrow Donor Association

BM:

bone marrow

PB:

peripheral blood

G-CSF:

granulocyte colony stimulating factor

CML:

chronic myeloid leukemia

CP1:

first chronic phase

IHWG:

International HLA Working Group

AML:

acute myeloid leukemia

ALL:

acute lymphoblastic leukemia

MDS:

myelodisplastic syndromes

TRM:

transplant related mortality

CsA:

cyclosporin

MTX:

methotrexate

FK:

tacrolimus

MMF:

mycofenolate mofetil

ATG :

anti-thymocyte globulin

GvHD:

graft versus host disease

RIC:

reduced intensity conditioning

FLU-CY:

fludarabine/cyclophosphamide

LFS:

leukemia free survival

CMV:

cytomegalovirus

EBV:

epstein barr virus

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Authors and Affiliations

  1. Ospedale San Martino, Genova, Italy

    A Bacigalupo

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  1. A Bacigalupo
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  1. University Hospitals Case Medical Center, Cleveland, OH, USA

    Hillard M. Lazarus

  2. Case Western Reserve University, Cleveland, OH, USA

    Mary J. Laughlin

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Bacigalupo, A. (2010). Unrelated Donor Transplants. In: Lazarus, H.M., Laughlin, M.J. (eds) Allogeneic Stem Cell Transplantation. Contemporary Hematology. Humana Press. https://doi.org/10.1007/978-1-59745-478-0_19

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  • DOI: https://doi.org/10.1007/978-1-59745-478-0_19

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