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Trafficking of Postsynaptic GABAA Receptors by Receptor-Associated Proteins

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The GABA Receptors

Part of the book series: The Receptors ((REC))

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Abstract

γ-Aminobutyric acid receptors (GABAA Rs) are the principal receptors that mediate neural inhibition in the brain. Changes in the function of GABAergic transmission are implicated in activity-dependent adaptation of neural excitability. Of particular interest are mechanisms that control the size of the postsynaptic GABAA-receptor pool, a major determinant of synaptic strength. Mechanisms of trafficking of postsynaptic GABAA Rs contribute to regulation of inhibitory synaptic transmission in response to changes in neural activity and extracellular stimuli. This review summarizes current information available on the receptor structures relevant for trafficking of GABAA Rs, the molecular composition of the submembrane cytoskeleton of inhibitory synapses, and the receptor interacting proteins that regulate the localization and trafficking of postsynaptic GABAA Rs during exocytosis, lateral diffusion and endocytic recycling, and degradative pathways.

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Authors and Affiliations

  1. Department of Biology, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA

    Xu Yuan MS & Bernhard Lüscher PhD

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  1. Xu Yuan MS
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  2. Bernhard Lüscher PhD
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  1. Departments of Molecular and Integrative Physiology and of Pharmcology, Toxicology and Therapeutics, University of Kansas, Kansas City, KS

    S. J. Enna

  2. Department of Chemistry and Applied Biosciecnes Swiss Federal Institute of Technology (ETH), Institute of Pharmacology University of Zurich, Zurich

    Hanns Möhler

  3. Collegium Helveticum, Zurich, Switzerland

    Hanns Möhler

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Yuan, X., Lüscher, B. (2007). Trafficking of Postsynaptic GABAA Receptors by Receptor-Associated Proteins. In: Enna, S.J., Möhler, H. (eds) The GABA Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-59745-465-0_3

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