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Cytokines in the Genesis and Treatment of Cancer pp 267–283Cite as

Chemokine and Receptor Expression in Tumor Progression

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Chemotactic cytokines (chemokines) are a family of small proteins (8–10 kDa) inducing directed cell migration (chemotaxis) along a chemical gradient (1–5). Chemokines tightly regulate the positioning of leukocytes in secondary lymphoid organs (e.g., in lymph nodes and thymus), and are key determinants of the recruitment of leukocytes at sites of inflammation and tumor tissues. Besides hematopoietic cells, chemokines affect several other cell types, such as epithelial and endothelial cells, fibroblasts and tumor cells. Chemokines play an important role in immune and inflammatory reactions; in addition most of these molecules affect other important cell functions such as angiogenesis, collagen production, activation of enzymes and regulation of cell growth and apoptosis. Forty-seven chemokines have been identified so far in man. Based on a cystein motif, different subfamilies: CXC, CC, C and CX3C have been classified (Table 1). The chemokine scaffold consists of an N-terminal loop connected via Cys bonds to the more structured core of the molecule (three b sheets) with a C terminal a helix (1–4).

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Authors and Affiliations

  1. Department of Immunology and Cell Biology, Istituto Mario Negri, Milano, Italy

    Paola Allavena MD, Federica Marchesi & Alberto Mantovani

  2. Centro IDET, Institute of General Pathology, University of Milan, Milan, Italy

    Alberto Mantovani

Authors
  1. Paola Allavena MD
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  2. Federica Marchesi
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  3. Alberto Mantovani
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Editors and Affiliations

  1. The Ohio State University Comprehensive Cancer Center, Columbus, OH

    Michael A. Caligiuri MD

  2. University of Pittsburgh Cancer Center, Pittsburgh, PA

    Michael T. Lotze MD (Director) (Director)

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Allavena, P., Marchesi, F., Mantovani, A. (2007). Chemokine and Receptor Expression in Tumor Progression. In: Caligiuri, M.A., Lotze, M.T. (eds) Cytokines in the Genesis and Treatment of Cancer. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-59745-455-1_15

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  • DOI: https://doi.org/10.1007/978-1-59745-455-1_15

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-820-2

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