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Transcription Factors as Regulators of Gene Expression During Leydig Cell Differentiation and Function

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The Leydig Cell in Health and Disease

Part of the book series: Contemporary Endocrinology ((COE))

Abstract

Transcription factors are at the center stage of several cellular processes, in which they play essential roles as receivers, interpreters, and conveyers of numerous extracellular signals. These signals are the cues to which cells must respond and transcription factors are indispensable to translate these signals into a genomic response. Depending on the signal, different transcription factors will be solicited leading to unique combinatorial interactions, or codes, required for the activation of specific sets of genes ultimately, triggering cell proliferation, specification, differentiation, function, or death. As for most cell types found throughout the body, testicular Leydig cells have a unique function; they produce the hormones (insulin-like 3 and testosterone) required for fertility and maleness in men. Several signals, such as hormones and signaling molecules, have been identified as important regulators of Leydig cell differentiation and function. Downstream of these signals are transcription factors. The aim of this chapter is to provide a description of the various families of transcription factors, which have been identified as regulators of Leydig cell gene expression and function.

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Authors and Affiliations

  1. Ontogeny-Reproduction Research Unit, CHUL Research Centre, Québec City, Québec, Canada

    Jacques J. Tremblay Msc, PhD, LLB

  2. Department of Obstetrics and Gynecology, Faculty of Medicine, Centre for Research in Biology of Reproduction, Université Laval, Québec City, Québec, Canada

    Jacques J. Tremblay Msc, PhD, LLB

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  1. Jacques J. Tremblay Msc, PhD, LLB
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Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA

    Anita H. Payne PhD

  2. Center for Biomedical Research, Population Council, New York, NY

    Matthew P. Hardy PhD

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© 2007 Humana Press Inc., Totowa, NJ

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Tremblay, J.J. (2007). Transcription Factors as Regulators of Gene Expression During Leydig Cell Differentiation and Function. In: Payne, A.H., Hardy, M.P. (eds) The Leydig Cell in Health and Disease. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-59745-453-7_23

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  • DOI: https://doi.org/10.1007/978-1-59745-453-7_23

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-754-9

  • Online ISBN: 978-1-59745-453-7

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