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Impact of A β and Tau on Cognition in Mouse Models of Alzheimer’s Disease

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Animal Models of Human Cognitive Aging

Part of the book series: Aging Medicine ((AGME))

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Abstract

Since the first patient was diagnosed with Alzheimer’s disease, scientists have attempted to study the pathological features associated with the disease in an attempt to find a cure. Although several biological markers have been implicated, including amyloid-beta plaques and neurofibrillary tangles, these correlative discoveries make it difficult to tease out cause-and-effect relationships. In an attempt to understand these relationships, genetic mutations that have been linked to Alzheimer’s disease have been replicated in several mouse models. These transgenic animals provide scientists with a valuable tool to study which pathologies can cause cognitive deficits and to discover what compounds or therapies may decrease these pathologies and behavioral impairments.

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Acknowledgments

We thank Dr. Anna Parachikova for critically reading the manuscript. This work was supported in part by grants from Alzheimer’s Association and the National Institutes of Health AG0212982 and AG16573 to FML.

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Authors and Affiliations

  1. Department of Neurobiology and Behavior, and Institute for Brain Aging and Dementia, University of California, Irvine, CA, USA

    Frank M. LaFerla

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  1. Maya A. Koike
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  2. Kristoffer Myczek
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  3. Kim N. Green
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  4. Frank M. LaFerla
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Correspondence to Frank M. LaFerla .

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Editors and Affiliations

  1. Dept. Psychology, Behavioral & Cellular, Texas A & M University, College Station, 77843-4235, U.S.A.

    Jennifer L. Bizon

  2. Padure Biomedical Consulting, Seeley Street 250, Brooklyn, 11218, U.S.A.

    Alisa Woods

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Koike, M.A., Myczek, K., Green, K.N., LaFerla, F.M. (2009). Impact of A β and Tau on Cognition in Mouse Models of Alzheimer’s Disease. In: Bizon, J., Woods, A. (eds) Animal Models of Human Cognitive Aging. Aging Medicine. Humana Press. https://doi.org/10.1007/978-1-59745-422-3_6

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