Restless Legs Syndrome and Periodic Limb Movements

  • Michael J. Thorpy
Part of the Current Clinical Practice book series (CCP)


Restless legs syndrome (RLS), a common sensory-motor disorder is characterized by uncomfortable sensations in the limbs, especially at rest and at bedtime (1). This paresthesia usually involves an irresistible urge to move the limbs, which provides temporary relief. The symptoms occur most often in the legs but can involve the arms or, in severe cases, the whole body. Although RLS occurs while the individual is awake, difficulty falling asleep, and sleep disruption as a result of periodic limb movements occurs (2). The pathophysiology of RLS is not well-understood; however, iron and central dopaminergic systems have been implicated (3).


Dopamine Agonist Sleep Medicine Periodic Limb Movement Periodic Limb Movement Disorder Periodic Limb Movement Disorder 
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Copyright information

© Humana Press Inc., Totowa, NJ 2007

Authors and Affiliations

  • Michael J. Thorpy
    • 1
  1. 1.Sleep/Wake Disorders CenterMontefiore HospitalNew York

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