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Cancer Neurology In Clinical Practice pp 353–378Cite as

Central Nervous System Infections in Cancer Patients

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Summary

Despite the development of effective prophylactic regimens and better antimicrobials for active infection, central nervous system infections in cancer patients continue to be a source of significant morbidity and mortality. The combination of more intense immunosuppression and longer survival has changed the spectrum of infections in several vulnerable populations. Patients at highest risk for CNS infection include hematopoietic cell transplant recipients and neurosurgical patients, although the intensity of chemotherapeutic regimens has resulted in an increased infection rate in patients with hematologic malignancies who do not receive transplants. The clinical presentation and radiographic appearance of infections in cancer patients may differ from those occurring in other populations, including HIV/AIDS patients. This chapter presents a systematic approach to the diagnosis of CNS infections in the most commonly affected patient groups based on patient risk factors, neuroanatomic site of disease, and laboratory tests. It then offers detailed clinical descriptions and management recommendations for the most common infections.

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Authors
  1. Amy A. Pruitt MD
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Editors and Affiliations

  1. School of Medicine, University of Virginia, Charlottesville, VA

    David Schiff MD

  2. Center for Neuro-Oncology Dana-Farber/Brigham and Women’s Cancer Center and Department of Neurology, Brigham and Women’s Hospital, Boston, MA

    Santosh Kesari MD, PhD  & Patrick Y. Wen MD  & 

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© 2008 Humana Press, Totowa, NJ

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Pruitt, A.A. (2008). Central Nervous System Infections in Cancer Patients. In: Schiff, D., Kesari, S., Wen, P.Y. (eds) Cancer Neurology In Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-59745-412-4_19

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  • DOI: https://doi.org/10.1007/978-1-59745-412-4_19

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-983-3

  • Online ISBN: 978-1-59745-412-4

  • eBook Packages: MedicineMedicine (R0)

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