• Douglas D. Glover
Part of the Forensic Science and Medicine book series (FSM)


Ginger has been promoted for a variety of medical conditions and is purported to have carminative, diaphoretic, spasmolytic, expectorant, peripheral circulatory stimulant, astringent, appetite stimulant, anti-inflammatory, diuretic, and digestive effects. It is most commonly used in the United States for its antinauseant effects to relieve and prevent motion sickness, and relieve morning sickness in pregnancy. Ginger has compared favorably to a variety of other antinauseant therapeutic agents including metoclopramide, dimenhydrinate, promethazine, and scopolamine. Studies assessing therapeutic benefit for other uses such as an anti-inflammatory or antimutagenic agent are less impressive. Ginger has enjoyed a long history of safe use and concerns over a theoretical interaction with antiplatelet drugs has not been confirmed in clinical practice or adverse event reports.

Key Words

Zingiber officinale nausea motion sickness 


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  1. 1.
    Leung AY. Ginger. In: Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. New York: John Wiley and Sons, 1980, p. 1845.Google Scholar
  2. 2.
    Anonymous, ed. The Lawrence review of natural products. St. Louis: Facts and Comparisons, 1991.Google Scholar
  3. 3.
    United States Pharmacopeial Convention (USP). Ginger. In: Botanical monograph series. Rockville: United States Pharmacopeial Convention, 1998.Google Scholar
  4. 4.
    Tyler VE, Brady LR, Robbers JE, eds. Pharmacognosy, 8th edition. Philadelphia: Lea and Febiger, 1981, p. 156.Google Scholar
  5. 5.
    Awang DVC. Ginger. CPJ 1992;125:309–311.Google Scholar
  6. 6.
    Altman RD, Marcussen KC. Effects of ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum 2001;44(l l):2531–2538.PubMedCrossRefGoogle Scholar
  7. 7.
    Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council, 1998.Google Scholar
  8. 8.
    Tyler VE, ed. Digestive system problems. In: Herbs of Choice: The Therapeutic Use of Phytomedicinals. Binghamton: Pharmaceuticals Products Press, 1994.Google Scholar
  9. 9.
    Holtmann S, Clarke AH, Scherer H, Hohn M. The anti-motion sickness mechanism of ginger. A comparative study with placebo and dimenhydrinate. Acta Otolaryngol 1989;108:168–174.PubMedGoogle Scholar
  10. 10.
    Mowrey DB, Clayson DE. Motion sickness, ginger, and psychophysics. Lancet 1982;1:6557.Google Scholar
  11. 11.
    Price NM, Schmitt LG, McGuire J, et al. Transdermal scopolamine in prevention of motion sickness at sea. Clin Pharmacol Ther 1981;29:414–419.PubMedCrossRefGoogle Scholar
  12. 12.
    Wood CD, Manno JE, Wood MJ, Manno BR, Mims ME. Comparison of efficacy of ginger with various antimotion sickness drugs. Clin Res Pr Drug Regul Aff 1988;6(2): 129–136.PubMedGoogle Scholar
  13. 13.
    Bone ME, Wilkinson DJ, Young JR, McNeil J, Charlton S. Ginger root — a new antiemetic. Anesthesia 1990;45:669–671.CrossRefGoogle Scholar
  14. 14.
    Arfeen Z, Owen H, Plummer JL, Ilsley AH, Sorby-Adams RAC, Doecke CJ. A double-blind randomized controlled trial of ginger for the prevention of postoperative nausea and vomiting. Anaesth Intens Care 1995;23:449–452.Google Scholar
  15. 15.
    Phillips S, Ruggier R, Hutchinson SE. Zingiber officinale (ginger) — an antiemetic for day case surgery. Anaesthesia 1993;48:715–717.PubMedCrossRefGoogle Scholar
  16. 16.
    Ernst E, Pittler MH. Efficacy of ginger for nausea and vomiting: a systemic review of randomized clinical trials. Br J Anaesth 2000;84(3):367–371.PubMedGoogle Scholar
  17. 17.
    Visalyaputra S, Petchpaisit N, Somcharoen K, Choavaratana R. The efficacy of ginger root in the prevention of postoperative nausea and vomiting after outpatient gynaecological laproscopy. Anaesthesia 1998; 53:486–510CrossRefGoogle Scholar
  18. 18.
    Fisher-Rasmussen W, Kjaer SK, Dahl C, Asping U. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol 1990;38:19–24.CrossRefGoogle Scholar
  19. 19.
    Vutyavanich T, Kraisarin T, Ruangsri RA. Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial. Obstet Gynecol 2001;97(4):577–582.PubMedCrossRefGoogle Scholar
  20. 20.
    Grontved A, Brask T, Kambskard J, Hentzer E. Ginger root against seasickness. Acta Otolaryngol 1988;105:45–49.PubMedGoogle Scholar
  21. 21.
    Stewart JJ, Wood MJ, Wood CD, Mims ME. Effects of ginger on motion sickness susceptibility and gastric function. Pharmacology 1991;42:111–120.PubMedGoogle Scholar
  22. 22.
    Phillips S, Hutchinson S, Ruggier R. Zingiber officinale does not affect gastric emptying rate. Anaesthesia 1993;48:393–395.PubMedCrossRefGoogle Scholar
  23. 23.
    Huang Q, Iwamoto M, Aoki S, et al Anti-5-hydroxytryptamine, effect of galanolactone, diterpenoid isolated from ginger. Chem Pharm Bull 1991;39(2): 397–399.PubMedGoogle Scholar
  24. 24.
    Lumb AB. Mechanism of antiemetic effect of ginger. Anaesthesia 1993;48:1118.PubMedCrossRefGoogle Scholar
  25. 25.
    Schechter JO. Treatment of disequilibrium and nausea in the SRI Discontinuation Syndrome. J Clin Psychiatry 1998;59:431–432.PubMedGoogle Scholar
  26. 26.
    Kiuchi F, Shibuya M, Sankawa U. Inhibitors of prostaglandin biosynthesis from ginger. Chem Pharmacol Bull 1982;30:754–757.Google Scholar
  27. 27.
    Srivastava KC. Effects of aqueous extracts of onion, garlic and ginger on platelet aggregation and metabolism of arachidonic acid in the blood vascular system: in vitro study. Prostagland Leukotr Med 1984;13:227–235.CrossRefGoogle Scholar
  28. 28.
    Bliddal H, Rosetzsky A, Schlichting P, et al. A randomized, placebo-controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritis. Osteoarthritis Cartilage 2000;8:9–12.PubMedCrossRefGoogle Scholar
  29. 29.
    Sharma JN, Srivastava KC, Gan EK. Suppressive effects of eugenol and ginger oil on arthritic rats. Pharmacology 1994;49:314–318.PubMedCrossRefGoogle Scholar
  30. 30.
    Mustafa T, Srivastava KC. Ginger (Zingiber officinale) in migraine headache. J Ethnopharmacol 1990;29:267–273.PubMedCrossRefGoogle Scholar
  31. 31.
    Kobayashi M, Shoji N, Ohizumi Y. Gingerol, a novel cardiotonic agent, activates Ca2+ pumping ATPase in skeletal and cardiac sarcoplasmic reticulum. Biochim Biophys Acta 1987;903:96–102.PubMedCrossRefGoogle Scholar
  32. 32.
    Shoji N, Iwasa A, Takemoto T, Ishida Y, Ohizumi Y. Cardiotonic principles of ginger (Zingiber officinale Roscoe). J Pharm Sci 1982;71:1174–1175.PubMedCrossRefGoogle Scholar
  33. 33.
    Srivastava KC. Effect of onion and ginger consumption on platelet thromboxane production in humans. Prostagland Leukotr Essent Fatty Acids 1989;35:183–185.CrossRefGoogle Scholar
  34. 34.
    Lumb AB. Effect of dried ginger on human platelet function. Thromb Haemost 1994;71:110–111.PubMedGoogle Scholar
  35. 35.
    Nakamura H, Yamamoto T. The active part of the [6]-gingerol molecule in mutagenesis. Mutat Res 1983;122:87–94.PubMedCrossRefGoogle Scholar
  36. 36.
    Nagabhushan M, Amonkar AJ, Bhide S V. Mutagenicity of gingerol and shogaol and antimutagenicity of zingerone in salmonella/microsome assay. Cancer Lett 1987;36:221–233.PubMedCrossRefGoogle Scholar
  37. 37.
    Kada T, Kazuyoshi M, Inuoue T. Anti-mutagenic action of vagetable factor(s) on the mutagenic principle of tryptophan pyrolysate. Mutat Res 1987;53:351–353.Google Scholar
  38. 38.
    Nakamura H, Yamamoto T. Mutagen and anti-mutagen in ginger, Zingerber officinale. Mutat Res 1982;103:119–126.PubMedCrossRefGoogle Scholar
  39. 39.
    Harris S. Jamaica ginger paralysis (a peripheral polyneuritis). South Med J 1930;23:375–380.Google Scholar
  40. 40.
    Valaer P. The examination of cresyl-bearing extracts of ginger. Am J Pharm 1930;102:571–574.Google Scholar
  41. 41.
    Backon J. Ginger in preventing nausea and vomiting of pregnancy: a caveat due to its thromboxane synthetase activity and effect on testosterone binding [letter]. Eur J Obstet Gynecol Reprod Biol 1991;42:163–164.PubMedCrossRefGoogle Scholar
  42. 42.
    United States Pharmacopoeia (USP). USP, 28th edition, 2091.Google Scholar

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© Humana Press Inc. 2007

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  • Douglas D. Glover

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