Although feverfew has been demonstrated to provide therapeutic benefit to isolated patient groups and at varying dosage levels, its clinical effectiveness has not been consistently reported. A variety of caveats associated with study design, identification or concentration of appropriate substance, or duration of evaluation from previous clinical studies complicate the assessment of the overall benefit of the herb. Despite inconsistent reports of effectiveness, the favorable safety profile and low risk of use suggest a positive risk benefit for patients looking for migraine prophylaxis treatment alternatives.
Key WordsTanacetum partheium migraine parthenolide oral ulceration sesquiterpene lactones
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