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Adipose Tissue and Adipokines in Health and Disease pp 291–305Cite as

Adipokines in Non-Alcoholic Fatty Liver Disease

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Part of the book series: Nutrition and Health ((NH))

Abstract

Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of clinicopathological conditions in patients who do not consume excessive amounts of alcohol; these conditions are characterized by hepatic steatosis with or without other pathological changes observed in liver biopsy. The pathogenesis of NAFLD and its progressive form (non-alcoholic steatohepatitis [NASH]) appears to be multifactorial and is the subject of intense investigation. Increasing evidence indicates that the pathogenesis of NAFLD and NASH is hastened by a disturbance in adipokine production. Decreased serum adiponectin and increased tumor necrosis factor-α, which are characteristic of obesity, appear to contribute to the development and progression of NASH. The role of leptin in the pathogenesis of NASH remains controversial and the involvement of serum resistin is primarily documented only in animal models, which may or may not be applicable to the human form of NAFLD. Finally, other adipokines such as vaspin, visfatin, and apelin may play important roles in the pathogenesis of NASH and require further investigation.

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Author information

Authors and Affiliations

  1. Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA

    Ancha Baranova PhD

  2. Center for the Study of Genomics in Liver Diseases, Falls Church, VA

    Ancha Baranova PhD

  3. Molecular and Microbiology Department, George Mason University, Falls Church, VA

    Ancha Baranova PhD

  4. George Mason-Inova Health System’s Translational Research Centers, Falls Church, VA

    Ancha Baranova PhD

  5. Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA

    Zobair M. Younossi MD, MPH

  6. George Mason-Inova Health System’s Translational Research Centers, Falls Church, VA

    Zobair M. Younossi MD, MPH

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  1. Ancha Baranova PhD
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  2. Zobair M. Younossi MD, MPH
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Editors and Affiliations

  1. Department of Human Nutrition, University of Illinois at Chicago, Chicago, IL

    Giamila Fantuzzi PhD

  2. Section of Endocrinology, Diabetes, and Metabolism Department of Medicine, University of Illinois at Chicago, Chicago, IL

    Theodore Mazzone MD

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Baranova, A., Younossi, Z.M. (2007). Adipokines in Non-Alcoholic Fatty Liver Disease. In: Fantuzzi, G., Mazzone, T. (eds) Adipose Tissue and Adipokines in Health and Disease. Nutrition and Health. Humana Press. https://doi.org/10.1007/978-1-59745-370-7_22

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